A5102007503- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Genetic Associations and Epidemiology
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Healthcare cost, quality, practices
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Effects of Radiation Exposure
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- RNA modifications and cancer
Wuhan University
2014-2025
Renmin Hospital of Wuhan University
2014-2025
Hubei Cancer Hospital
2020
The outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency.
Patients with locally advanced oral squamous cell carcinoma (OSCC) have poor outcomes standard care. Neoadjuvant therapy is shown to be effective for these patients. In the randomized, two-arm, phase 2, non-comparative trial, we investigate efficacy and safety of neoadjuvant programmed death 1 (PD-1) inhibitor camrelizumab or without docetaxel-cisplatin-5-fluorouracil (TPF) chemotherapy in patients resectable OSCC. stage III-IVA OSCC receive three cycles (arm Cam) two TPF Cam+TPF), followed...
miR-196b plays a significant role in the regulation of tumor pathogenesis and progression by promoting cell proliferation, invasion metastasis. In order to explore effects on proliferation ability gastric cancer cells involved mechanisms, present study lentivirus expression vector was constructed transfected into human line MKN28. The were observed PI3K/AKT/mTOR protein mRNA analyzed following upregulation miR-196b. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) results...
Background Individualized prediction of mortality risk can inform the treatment strategy for patients with COVID-19 and solid tumors potentially improve patient outcomes. We aimed to develop a nomogram predicting in-hospital tumors. Methods enrolled admitted 32 hospitals in China between December 17, 2020, March 18, 2020. A multivariate logistic regression model was constructed via stepwise analysis, subsequently developed based on fitted model. Discrimination calibration were evaluated by...
Glioblastoma multiforme (GBM), the most common malignant primary brain tumor, has a very poor prognosis. With increasing knowledge of tumor molecular biology, targeted therapies are becoming increasingly integral to comprehensive GBM treatment strategies. mTOR is key downstream molecule PI3K/Akt signaling pathway, integrating input signals from growth factors, nutrients, and energy sources regulate cell proliferation through multiple cellular responses. mTOR/PI3K dual-targeted therapy shown...
Background To the authors' knowledge, little is known regarding association between recent oncologic treatment and mortality in patients with cancer who are infected coronavirus disease 2019 (COVID‐19). The objective of current study was to determine whether associated a higher risk death among carcinoma hospitalized COVID‐19. Methods Data 248 consecutive were COVID‐19 collected retrospectively from 33 hospitals Hubei Province, China, January 1, 2020, March 25, 2020. follow‐up cutoff date...
Circulating tumor cell (CTC) detection methods based on epithelial adhesion molecule (EpCAM) have low rates in ovarian cancer (EOC). Meanwhile, folate receptor alpha (FRα) has high expression EOC cells. We explored the feasibility of combining FRα and EpCAM as CTC capture targets EOC.EpCAM antibodies were linked to magnetic nanospheres (MNs) using principle carbodiimide chemistry. Blood samples from healthy donor spiked with A2780 cells used for detecting rate. Ninety-five blood 30 patients...
The aim of the present study was to investigate acceleration pulmonary metastasis due injury caused by radiation treatment in a mouse model breast cancer, addition determining associated mechanism. passive metastatic cancer used radiation‑treated BALB/c mice. In total, 24 mice were randomly separated into two groups, with 12 per group, and groups treated or without radiation. survival time variation weights lungs, spleen liver recorded. Lung also evaluated, chemokine (C‑X‑C motif) ligand...
Abstracts Background Cancer patients are considered to be highly susceptible viral infections, however, the comprehensive features of COVID-19 in these remained largely unknown. The present study aimed assess clinical characteristics and outcomes a large cohort cancer patients. Design, Setting, Participants Data consecutive admitted 33 designated hospitals for Hubei province, China from December 17, 2019 March 18, 2020 were retrospectively collected. follow-up cutoff date was April 02, 2020....
In Asian populations with non-small-cell lung cancer (NSCLC), EGFR mutations are highly prevalent, occurring in roughly half of these patients. Studies have revealed that individuals mutation typically fare worse immunotherapy. patients who received tyrosine kinase inhibitor (TKI) treatment followed by anti-PD-1 therapy, poor results were observed. The underlying mechanism remains unclear. We used high-resolution flow cytometry and ELISA to detect the circulating level small extracellular...
Background The study was conducted to evaluate the feasibility of using malignant pleural effusion (MPE) as a substitute specimen for genetic testing and determine significance profiling MPE tumor cells monitor non‐small cell lung cancer (NSCLC) progression therapeutic response. Methods We selected 168 NSCLC patients with MPE. extracted enriched custom‐designed device. EGFR mutations ALK / ROS1 fusions were then detected by quantitative real‐time PCR, results used guide targeted therapy....
This study was conducted to investigate if radiotherapy improved the overall survival (OS) of patients with oligometastatic non-small cell lung cancer (NSCLC).From January 2012 August 2015, 323 NSCLC distant metastasis were administered radiotherapy. Ninety-five who sensitive initial chemotherapy treated for residual lesions. Initial treatment consisted four six cycles induction chemotherapy. If responded without developing new metastases, sites radiated at a total dose 56-66 Gy, including...
Brain metastases (BMs) develop in 20-65% of non-small cell lung cancer (NSCLC) patients and are associated with a poor prognosis. Apatinib, tyrosine kinase inhibitor (TKI) that selectively inhibits the vascular endothelial growth factor receptor 2, is safe significantly prolongs survival chemotherapy-refractory gastric patients. This retrospective study evaluated safety efficacy apatinib combined concurrent brain radiotherapy NSCLC BMs.This trial enrolled non-recurrent BM from...
Primary gastric adenosquamous carcinoma (ASC) is an exceedingly rare histological subtype. Gastric signet ring cell (SRC) a unique subtype with distinct tumor biology and clinical features. The prognosis of ASC vs SRC has not been well established to date. We hypothesized that further knowledge about these cancers would improve the management such patients.To investigate clinicopathological characteristics SRC.A cohort cancer patients was retrospectively collected from Surveillance,...
Background and purpose. A large sample size study on survival analysis of radiotherapy in ovarian cancer is deficient. This aimed to explore the impact cancer. Materials methods. Data patients diagnosed with between 2010 2015 were collected from Surveillance, Epidemiology, End Results (SEER) Database. Survival comparisons analyzed using Kaplan–Meier log-rank tests. Univariate multivariate Cox regression analyses used select predictors associated survival. Propensity score matching (PSM) was...
The 2019 novel coronavirus has spread rapidly around the world. Cancer patients seem to be more susceptible infection and disease deterioration, but factors affecting deterioration remain unclear. We aimed develop an individualized model for prediction of (COVID-19) in cancer patients. clinical data 276 diagnosed with COVID-19 33 designated hospitals Hubei, China from December 21, March 18, 2020, were collected randomly divided into a training validation cohort by ratio 2:1. Cox stepwise...
AIM: To evaluate the potential prognostic value of GNAS1 T393C polymorphism in advanced non-small cell lung cancer. METHODS:We extracted genomic DNA from peripheral blood leucocytes 94 patients with cancer.Quantitative real-time polymerase chain reaction was used to determine allelic discrimination.The correlation between genotype and overall survival evaluated using multivariate analysis Kaplan-Meier approach.RESULTS: Thirty-eight out (40%) displayed a TT genotype, 29 (31%) CT 27 (29%) CC...
Chemotherapy-induced myelosuppression is one of the main problems in treatment cancer. In present study, effects allogeneic umbilical cord blood hematopoietic stem cell (UCB-HSC) infusion were investigated on chemotherapy-related myelosuppression. total, 65 patients (male, 42; female, 23) diagnosed with included study. The majority classified stage II myelosupression at enrolment, and an average concentration 7.07×109/l UCB-HSCs transfused through peripheral vein. minimum values white (WBC)...
Objective: To explore the clinical and pathological features of gastric signet ring cell carcinoma, evaluate survival impact preoperative radiotherapy on these patients. Methods: The Surveillance, Epidemiology, End Results database was used to extract eligible patients from 2004 2015. were divided into those with without radiotherapy. categorical variables described by chi-square tests. patients’ compared between 2 groups Kaplan-Meier method log-rank Cox proportional hazard model adopted...
Normal tissue complication probability (NTCP) models for radiation pneumonitis (RP) in lung cancer patients with stereotactic body therapy (SBRT), which based on dosimetric data from treatment planning, are limited to who have already received (RT). This study aims identify a novel predictive factor dose distribution and RP before devising actionable SBRT plans patients. A comprehensive correlation analysis was performed the clinical parameters of underwent SBRT. Linear regression were...