A5025895769- interferon and immune responses
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Brain Metastases and Treatment
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- COVID-19 and healthcare impacts
- FOXO transcription factor regulation
- Radiopharmaceutical Chemistry and Applications
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Renal cell carcinoma treatment
- Infection Control and Ventilation
- Cancer, Hypoxia, and Metabolism
Hubei Cancer Hospital
2014-2025
Huazhong University of Science and Technology
2019-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2025
Huazhong University of Science and Technology Hospital
2021
Zhongnan Hospital of Wuhan University
2018-2019
Wuhan University
2019
Immune checkpoint blockade (ICB) has revolutionized cancer therapy. However, the response of patients to ICB is difficult predict. Here, we examined 81 with lung under treatment and found that MET amplification were resistant had a poor progression-free survival. Tumors amplifications significantly decreased STING levels antitumor T-cell infiltration. Furthermore, performed deep single-cell RNA sequencing on more than 20,000 single immune cells identified an immunosuppressive signature...
OBJECTIVE: To investigate the correlation between expression of PD-L1 and HIF-1α in hepatocellular carcinoma (HCC) tissue further analyze association with clinical parameters prognostic value coexpression HCC patients. METHODS: We assessed by immunohistochemistry tumor from 90 patients who underwent curative hepatectomy. The results were validated an independent cohort additional RESULTS: exhibited high rates 41.11% (37/90) 43.33% (43/90), respectively, their expressions positively...
PANoptosis is a newly described inflammatory programmed cell death, that highlights coordination between pyroptosis, apoptosis and necroptosis.However, the functions of PANoptosis-related genes in glioma progression still remain to be explored.This study aims identify predictors may utilized for prognosis prediction development new therapeutic targets.Firstly, bulk single-cell RNA-seq (scRNA-seq) data patients were extracted from TCGA, CGGA GEO database.Genetic analysis indicates...
Breast cancer (BC) is one of the most common malignant tumours in women. The matrix metalloproteinase (MMP) enzyme family plays a complex role development BC. There increasing evidence that MMP11 major BC; however, underlying mechanisms are not clear. present study confirmed by analysing clinical samples and TCGA data sets, high expression BC was strongly associated with poor prognosis patients. In addition, MTT colony formation assays indicated proliferative capacity affected when changed....
Ondansetron orally soluble pellicle can serve as an alternative option for preventing nausea and vomiting in patients who receive chemotherapy. However, there is a lack of clinical evidence regarding ondansetron. This study aimed to explore the efficacy safety ondansetron with malignant tumours received chemotherapy drugs moderate-to-high emetic risk. In total, 163 24 mg via pellicles at 30 min before (8 each time three consecutive administrations). The incidence rates days after were...
Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute 10 days after paclitaxel and CDDP administration at the recommended dose described in present case report, PTX- CDDP-induced summarized according previous reports. Possible mechanisms potential...
Abstract Background and Purpose The optimal number of cycles induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LANPC) remains unresolved. This study aimed to quantitatively assess the changes gross tumor volumes (GTVs) select most IC cycles. Methods We analyzed 54 patients who received a three‐cycle before commencing radiotherapy, with nodal responses assessed by CT scan after each cycle. nasopharynx primary lesion (GTV_T), involved retropharyngeal lymph node...
Radiation-induced lung injury (RILI) is a common side effect in patients with non-small cell cancer (NSCLC) treated radiotherapy. Minimizing irradiation into highly functional areas of the may reduce occurrence RILI. The aim this study to evaluate feasibility and utility hyperpolarized xenon-129 magnetic resonance imaging (MRI), an tool for evaluation pulmonary function, guide radiotherapy planning.Ten locally advanced NSCLC were recruited. Each patient underwent simulation computed...
Immune checkpoint blockade (ICB) therapies have redefined human cancer treatment, including for head and neck squamous cell carcinoma (HNSCC). However, clinical responses to various immune inhibitors are often accompanied by immune-related adverse events (irAEs). Therefore, it is crucial obtain a comprehensive understanding of the association between different tumor microenvironments (TMEs) immunotherapeutic response.The research data were obtained from The Cancer Genome Atlas (TCGA)...
Abstract Background The objective of this study was to develop and validate a nomogram predict 1-year overall survival (OS) 2-year OS in patients with high-grade digestive neuroendocrine neoplasms (NENs) as well guide selection subgroups that could benefit from systemic chemotherapy. Subjects, Materials, Methods We performed retrospective analysis 223 NENs the gut hepato-biliary-pancreatic system four centers included development cohort. externally validated cohort 90 another one. Results...
Abstract Background The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly used systems for pancreatic neuroendocrine tumors. This study aims to identify most accurate useful tumor–node–metastasis (TNM) system poorly differentiated carcinomas (pNECs). Methods An analysis was performed evaluate application of ENETS, 7th edition (7th) AJCC 8th (8th) using Surveillance, Epidemiology, End Results (SEER) registry...
Background: Because the vast majority of nasopharyngeal carcinoma (NPC) in Chinese patients is a direct result Epstein–Barr virus (EBV) infection, there dearth data for EBV-negative this population. This multicenter study sought to examine clinical characteristics and compare long-term outcomes with propensity-matched (1:1.5) EBV-positive cohort. Methods: NPC known EBV status from four hospitals were collated (2013–2021). A logistic regression model was conducted evaluate relationship...
Background: Circular RNA hsa_circ_0087378 (circ_0087378) has been found to have different functions in cancer types. However, its function non-small cell lung (NSCLC) remains unclear. This study revealed the effect of circ_0087378 on malignant behavior NSCLC cells vitro broaden options for treatment. Methods: detected expression via real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The discoidin domain receptor 1 (DDR1) protein was investigated through western...
BACKGROUND The early diagnosis rate of esophageal cancer (EC), one the most prevalent digestive tract cancers worldwide, remains low. AIM To investigate utility plasma SHOX2 , SEPTIN9 EPO and RNF180 methylation in clinical monitoring EC. METHODS Plasma samples were collected from 210 patients at Hubei Cancer Hospital, TaqMan polymerase chain reaction was employed to detect methylation. area under curve used estimate their diagnostic value for Cox logistic regression analyses independent...
Background: During the coronavirus disease 2019 (COVID-19) epidemic, tumor patients and their families might suffer from greater psychological stress as a result of anxiety or other disorders. We conducted an online study during epidemic to explore mental state this extraordinary time.Methods: A cross-sectional survey was carried out. Questionnaires were distributed through WeChat "Questionnaire Star" network. The snowball sampling technique adopted further promoted by subjects who had...
N6-methyladenosine (m6A) methylation is of significant importance in the initiation and progression tumors, but how specific genes take effect different lung cancers still needs to be explored. The aim this study analyze correlation between m6A RNA regulators occurrence development cancer. data adenocarcinoma (LUAD) squamous cell carcinoma (LUSC) were obtained through TCGA database. We systematically analyzed related pathological characteristics prognostic factors by applying univariate...