A5044786927- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Cancer Genomics and Diagnostics
- Nicotinic Acetylcholine Receptors Study
- Ferroptosis and cancer prognosis
- Water Treatment and Disinfection
- Renal cell carcinoma treatment
- Sperm and Testicular Function
- Cancer-related gene regulation
- Receptor Mechanisms and Signaling
- Fibroblast Growth Factor Research
- Renal and related cancers
- Pain Mechanisms and Treatments
- Bladder and Urothelial Cancer Treatments
- Advanced Proteomics Techniques and Applications
- Circular RNAs in diseases
- Advanced Text Analysis Techniques
- Legionella and Acanthamoeba research
Shenzhen Second People's Hospital
2016-2025
Shenzhen University
2011-2025
Fujian Medical University
2025
North Sichuan Medical University
2024-2025
Northeast Petroleum University
2020-2024
China Power Engineering Consulting Group (China)
2024
Sichuan University
2010-2024
West China Second University Hospital of Sichuan University
2024
Beijing Proteome Research Center
2017-2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Background MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They aberrantly expressed in many types cancers. In this study, we determined the genome-wide miRNA profiles bladder urothelial carcinoma by deep sequencing. Methodology/Principal Findings We detected 656 differentially known human miRNAs and antisense sequences (miRNA*s) nine patients Many miRNA*s were significantly upregulated or downregulated compared to matched histologically normal...
Abstract Several studies have shown that tRNAs can be enzymatically cleaved to generate distinct classes of tRNA-derived fragments (tRF). Here, we report tRF/miR-1280, a 17-bp fragment derived from tRNALeu and pre-miRNA, influences Notch signaling pathways support the function cancer stem-like cells (CSC) in colorectal progression. tRF/miR-1280 expression was decreased human specimens cancer. Ectopic reduced cell proliferation colony formation, whereas its suppression reversed these effects....
The rapid development of autonomous driving and mobile mapping calls for off-the-shelf LiDAR SLAM solutions that are adaptive to LiDARs different specifications on various complex scenarios. To this end, we propose MULLS, an efficient, low-drift, versatile 3D system. For the front-end, roughly classified feature points (ground, facade, pillar, beam, etc.) extracted from each frame using dual-threshold ground filtering principal components analysis. Then registration between current local...
The accelerating development of autonomous driving technology has placed greater demands on obtaining large amounts high-quality data. Representative, labeled, real world data serves as the fuel for training deep learning networks, critical improving self-driving perception algorithms. In this paper, we introduce PandaSet, first dataset produced by a complete, high-precision vehicle sensor kit with no-cost commercial license. was collected using one 360° mechanical spinning LiDAR,...
Mitogen-activated protein kinase (MAPK) pathways are major mediators of extracellular signals that transduced to the nucleus. MAPK signaling is attenuated at several levels, and one class dual-specificity phosphatases,the phosphatases (MKPs), inhibit by dephosphorylating activated MAPKs. Several MKPs themselves induced they regulate, forming negative feedback loops attenuate signals. We show here in mouse embryos, Fibroblast growth factor receptors (FGFRs) required for transcription Dusp6,...
Cancers arise through an evolutionary process in which cell populations are subjected to selection; however, date, the of bladder cancer, is one most common cancers world, remains unknown at a single-cell level. We carried out exome sequencing 66 individual tumor cells from muscle-invasive transitional carcinoma (TCC). Analyses somatic mutant allele frequency spectrum and clonal structure revealed that were derived single ancestral cell, but subsequent evolution occurred, leading two...
Tumor metastasis is a hallmark of colorectal cancer (CRC), in which exosome plays crucial role with its function intercellular communication. Plasma exosomes were collected from healthy control (HC) donors, localized primary CRC and liver-metastatic patients. We performed proximity barcoding assay (PBA) for single-exosome analysis, enabled us to identify the alteration subpopulations associated progression. By vitro vivo experiments, biological impact these on proliferation, migration,...
Despite its well-defined role as a serum growth factor during fetal liver development and hepatic oncogenesis, the biological significance of cytoplasmic alpha-fetoprotein (AFP) remains incompletely understood. Here, we provide evidence to illustrate that AFP may function regulator in phosphatidylinositol 3-kinase (PI3K)/AKT pathway human hepatocellular carcinoma cells. The results demonstrated colocalization interaction phosphatase tensin homolog deleted on chromosome 10 (PTEN) cytoplasm...
Human β-defensin 1 plays a dual role in defending male fertility by promoting both the motility of sperm and its bactericidal activity.
Background: Polyphyllin VII (PP7), a steroidal saponin from Paris polyphylla, has been found to exert strong anticancer activity. Little is known about the anti-inflammatory property of PP7. In this study, activity and its underlying mechanisms PP7 were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells multiple animal models. Methods: The content nitric oxide (NO) was determined by spectrophotometry. levels prostaglandin E2 (PGE₂) cytokines measured enzyme-linked immunosorbent...
Abstract Because of the lack sensitivity to radiotherapy and chemotherapy, therapeutic options for renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial roles in progression cancer. However, their functional upstream mechanisms KIRC remain largely unknown. Exploring functions potential essential lncRNAs may lead discovery novel targets diagnosis treatment KIRC. Here, according integrated analysis RNA sequencing survival data TCGA-KIRC datasets,...