A5048868468- Mesenchymal stem cell research
- Hair Growth and Disorders
- Extracellular vesicles in disease
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Adipose Tissue and Metabolism
- dental development and anomalies
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cystic Fibrosis Research Advances
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Bone and Dental Protein Studies
- Entomopathogenic Microorganisms in Pest Control
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Dermatology and Skin Diseases
- Pancreatic function and diabetes
- Cancer and Skin Lesions
- Ovarian cancer diagnosis and treatment
Guangzhou Medical University
2007-2025
University of British Columbia
2007-2025
Loma Linda University
2025
Sichuan University
2015-2024
State Key Laboratory of Oral Diseases
2013-2024
West China Hospital of Sichuan University
2024
Sichuan University of Science and Engineering
2024
Shaoxing University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2023
Nanjing University of Chinese Medicine
2022-2023
Abstract The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult patients with cystic fibrosis (CF), a disease caused by mutations the gene encoding CF transmembrane conductance regulator (CFTR), develop CF-related diabetes (CFRD) most exhibiting insufficiency. Here we show that CFTR is glucose-dependent electrical acitivities and secretion β-cells. We demonstrate glucose elicited whole-cell currents, membrane depolarization, bursts or action potentials, Ca...
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
Adipose tissue is an active endocrine organ that can secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition soluble proteins in adipose tissue, microRNAs (miRNAs) enriched extracellular vesicles (EVs), such as exosomes or microvesicles, could modulate intercellular communications. this study, we demonstrated exosome-like derived from (Exo-AT) were internalized by tissue-derived stem cells (ADSCs), and these, turn, induced adipogenesis. High-throughput...
Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural structure as a template, constructing an engineered repair module is important scheme to realize functional regeneration and of maxillofacial tissue. Here, inspired biomineralization process, we constructed composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) dentin (TDM). The...
ABSTRACT 38K ( ac98 ) of Autographa californica multiple nucleopolyhedrovirus (Ac M NPV) is a highly conserved baculovirus gene whose function unknown. To determine the role in life cycle, knockout bacmid containing Ac NPV genome was generated through homologous recombination Escherichia coli . Furthermore, repair constructed by transposing open reading frame with its native promoter region into polyhedrin locus bacmid. After transfection these viruses Spodoptera frugiperda cells, led to...
Nitrogen fertilizer tends to migrate into the environment through runoff, leaching and volatilization, causing severe environmental pollution. In this work, a high-performance water nutrient loss control (WNLCF) was developed by adding high-energy electron beam (HEEB) dispersed attapulgite (HA)–sodium polyacrylate (P)–polyacrylamide (M) complex traditional fertilizer. Therein, HA-P-M used as agent (WNLCA), which could self-assemble form three-dimensional (3D) micro/nano networks in aqueous...
Human β-defensin 1 plays a dual role in defending male fertility by promoting both the motility of sperm and its bactericidal activity.
Cystic fibrosis (CF) is the most common life-limiting recessive genetic disease among Caucasians caused by mutations of cystic transmembrane conductance regulator (CFTR) with over 95% male patients infertile. However, whether CFTR could affect spermatogenesis and result in azoospermia remains an open question. Here we report compromised spermatogenesis, significantly reduced testicular weight sperm count, decreased cAMP-responsive element binding protein (CREB) expression testes knockout...
Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor of odontoblasts, which responsible for dentin development. However, our previous studies have indicated follicle (DFCs) can differentiate into odontoblasts. To further understanding development, and differences in dentinogenesis between DFCs DPCs, odontogenic differentiation DPCs was characterized vitro vivo. were individually combined with treated matrix (TDM) before they subcutaneously implanted...
The success of soft-tissue augmentation is offset by the low survival rates grafted fat tissue. Research shows that adipose-derived stem cells (ASCs) and platelet-rich plasma (PRP) are beneficial to tissue healing.To evaluate long-term effects different volume fractions PRP combined with ASCs on graft.ASCs were isolated from human tissue, was obtained blood. Cell count kit-8 real-time polymerase chain reaction (PCR) used influence (0%, 10%, 20%, 30%; volume/volume [v/v]) in medium ASC...
Abstract Successful dental pulp regeneration is closely associated with rapid revascularization and angiogenesis, processes driven by the Jagged1(JAG1)/Notch signaling pathway. However, soluble Notch ligands have proven ineffective in activating this To overcome limitation, a hydrogel developed indirectly immobilizing JAG1, aimed at precisely directing of vascularized tissue. This displays favorable mechanical properties biocompatibility. Cultivating stem cells (DPSCs) endothelial (ECs) on...
The present study examined the effect of hepatoma-associated antigen HAb18G (homologous to CD147) expression on NO/cGMP-regulated Ca<sup>2+</sup> mobilization and metastatic process human hepatoma cells. HAb18G/CD147 cDNA was transfected into 7721 cells obtain a cell line stably expressing HAb18G/CD147, T7721, as demonstrated by Northern blot immunocytochemical studies. 8-Bromo-cGMP (cGMP) inhibited thapsigargin-induced entry in concentration-dependent manner cGMP-induced inhibition...
Successful treatment of human immunodeficiency virus infection may ultimately require targeting hematopoietic stem cells. Here we used retroviral vectors carrying the ribozyme gene to transduce CD34+ cells from fetal cord blood. Transduction and expression had no apparent adverse effect on cell differentiation and/or proliferation. The macrophage-like cells, differentiated stem/progenitor in vitro, expressed resisted by a macrophage tropic type 1. These results suggest feasibility therapy...