A5026343875- Ovarian function and disorders
- Reproductive Biology and Fertility
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Reproductive System and Pregnancy
- Complementary and Alternative Medicine Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Technologies
- Phytoestrogen effects and research
- Estrogen and related hormone effects
- Sexual function and dysfunction studies
- Gestational Diabetes Research and Management
- Traditional Chinese Medicine Studies
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Effects and risks of endocrine disrupting chemicals
Women's Hospital, School of Medicine, Zhejiang University
2016-2025
Zhongshan People's Hospital
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2020-2024
University of Jinan
2020-2024
Zhejiang Gongshang University
2011-2023
Harbin University of Science and Technology
2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
Xiamen University
2022
Capital Medical University
2022
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
Context:The elevated low-density-lipoprotein cholesterol (LDL-C) in menopausal women is associated with higher risks of cardiovascular diseases.
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause subfertility. The mechanism underlying pathophysiology PCOS remains to be illustrated. Here, we identify two alternative splice variants (ASVs) androgen receptor (AR), insertion deletion isoforms, in granulosa cells (GCs) ∼62% patients with PCOS. AR ASVs are strongly associated remarkable hyperandrogenism abnormalities folliculogenesis, absent from all control subjects without...
Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients make epigenetic insights into the pathogenesis PCOS. Included were 110 women with 119 normal ovulatory cycles undergoing vitro fertilization acting as control group. RNA-seq identified 92 DEGs unique GCs comparison Bioinformatic analysis...
During the COVID-19 epidemic period, Traditional Chinese Medicine (TCM) course for international students of Medical Bachelor, Bachelor Surgery (MBBS) program in Zhejiang University has shifted from traditional classroom to online environment. This study aimed investigate MBBS students' perception on TCM course, and assess learning efficacy.A total 84 attending "Basic Medicine" during 2020 academic years at were enrolled this study. A quantitative questionnaire was respectively completed...
Objective. To explore the effects of overweight and obesity on outcomes in vitro fertilisation (IVF) Chinese infertile patients.Study design. A retrospective cohort study was carried out 2222 normal weight (18.5 ≤ BMI < 25), 379 (25 30) 27 obese (BMI ≥ women who underwent their first IVF cycles between 2002 2008. Cycle characteristics were analysed.Results. Obese required significantly higher dose rFSH (3272 IU vs. 2587 IU, p 0.001) days stimulation (11.89 ± 4.57 10.42 2.03, 0.001), but...
Abstract Background Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo directed by methyltransferases (DNMTs), important for embryo development. Abnormal function of these DNMTs may have serious consequences embryonic Methods To evaluate the possible involvement in human EPL, expression DNMT proteins global were assessed villous or decidua from EPL patients. The...
In this study, we aimed to determine the effects of hepatitis B virus (HBV) infection on sperm quality and outcome assisted reproductive technology (ART).A total 916 men (457 HBV-positive 459 HBV-negative) seeking fertility assistance from January 2008 December 2009 at Women's Hospital in School Medicine Zhejiang University were analysed for semen parameters.Couples which surface antigen (HBsAg)-seropositive categorized as included 587 vitro fertilisation (IVF) 325 intracytoplasmic injection...
Abstract Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need to be better defined. This study aimed investigate whether AQP3, one expressed highly in breast cancer, had any clinical implication estrogen-receptor (ER) positive cancer explore regulatory mechanisms AQP3 estrogen-related progression. Here we show is an important enforcer migration invasion cancer. We, for...
Polycystic ovary syndrome (PCOS) is one of the most common metabolic and reproductive endocrinopathies. However, few studies have tried to develop a diagnostic model based on gene biomarkers. In this study, we applied computational method by combining two machine learning algorithms, including random forest (RF) artificial neural network (ANN), identify biomarkers construct model. We collected expression data from Gene Expression Omnibus (GEO) database containing 76 PCOS samples 57 normal...
Objective Endometriosis is a common benign disease in women of reproductive age. Qu’s formula (QUF) patented Chinese herbal medicine for treating endometriosis that has been proven to be effective and preventing the recurrence endometriosis. This study aimed discover its molecular mechanism explore potential drug targets. Methods A QUF target endometriosis-related gene set was identified by Traditional Medicine Systems Pharmacology (TCMSP) Bioinformatics Analysis Tool Molecular Mechanism...
To study the efficacy of electro-acupuncture for relief labor pain, and to build a better understanding how might influence neuroendocrine system, 36 primiparas were randomly divided into an group control group. Assessments pain intensity degree relaxation during analyzed. The differences between on concentration beta-endorphin (beta-EP) 5-hydroxytryptamine (5-HT) in peripheral blood compared. was found exhibit lower than (p = 0.018; p 0.031). There existed significant difference beta-EP...
The present study was designed to evaluate whether the alteration of aquaporin-9 (AQP-9) expression in granulosa cells (GCs) patients with polycystic ovary syndrome (PCOS) associated hyperandrogenism follicular fluid (FF). We recruited infertile women PCOS (n = 14) and tubal blockage (controls, n 31) for this study. examined total testosterone (TT), free androgen index (FAI), sex hormone-binding globulin (SHBG), FSH, LH estradiol FF. Real-time PCR western blotting were performed assess AQP-9...