A5037987356- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Fatty Acid Research and Health
- Infant Development and Preterm Care
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Maternal Mental Health During Pregnancy and Postpartum
- Pediatric Pain Management Techniques
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Early Childhood Education and Development
- Infant Health and Development
- Child and Adolescent Psychosocial and Emotional Development
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Child and Animal Learning Development
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Cancer, Stress, Anesthesia, and Immune Response
University of British Columbia
2015-2024
British Columbia Children's Hospital
1997-2024
John Wiley & Sons (United States)
2017
Bioengineering Center
2017
National Center for Genetic Engineering and Biotechnology
2017
Edison Pharmaceuticals (United States)
2016
Child and Family Research Institute
2006-2015
Vancouver Coastal Health
2007-2015
Fontbonne University
2014
Idaho State University
2014
Background: In animal models, variations in early maternal care are associated with differences hypothalamic-pituitary-adrenal (HPA) stress response the offspring, mediated via changes epigenetic regulation of glucocorticoid receptor (GR) gene (Nr3c1) expression. Objective: To study this humans, relationships between prenatal exposure to mood and methylation status a CpG-rich region promoter exon 1F human GR (NR3C1) newborns HPA reactivity at age 3 months were examined. Methods: The NR3C1...
Data from animal models indicate that neonatal stress or pain can permanently alter subsequent behavioral and/or physiological reactivity to stressors. However, cumulative effects of related acute procedures in the intensive care unit (NICU) on later has received limited attention. The objective this study is examine relationships between prior exposure (number skin breaking procedures), and preterm infants NICU. Eighty-seven were studied at 32 (+/-1 week) postconceptional age (PCA). Infants...
Objectives. Stress systems may be altered in the long term preterm infants for multiple reasons, including early exposure to procedural pain neonatal intensive care. This question has received little attention beyond hospital discharge. responses (cortisol) visual novelty who were born at extremely low gestational age (ELGA; ≤28 weeks), very (VLGA; 29–32 and compared 8 months of corrected prematurity (corrected chronological [CCA]). In addition, among infants, we evaluated whether cortisol...
Acute stress impairs memory retrieval and facilitates the induction of long-term depression (LTD) in hippocampal CA1 region adult rodent brain. However, whether such alterations synaptic plasticity cause behavioral effects is not known. Here, we report that two selective inhibitors or expression stress-enabled, N -methyl- d -aspartate receptor-dependent LTD also block spatial impairments caused by acute stress. Additionally, demonstrate facilitating vivo blockade glutamate transport mimics...
Enhanced dopamine efflux in the prefrontal cortex is a well-documented response to acute stress. However, underlying mechanism(s) for this unknown. Using vivo microdialysis, we demonstrate that blocking glucocorticoid receptors locally within rat results reduction stress-evoked efflux. In contrast, ventral tegmental area did not affect cortex. Additionally, local administration of corticosterone into increased The functional impact enhanced evoked by stress was demonstrated using cognitive...
This study investigated the Interactive effects of alcohol and nutritional status pregnant female on fetal growth development Three liquid diets were formulated ranging in protein content from suboptimal to supraoptimal: diet I provided 18% kcal as 1.0 kcal/ml; II III 25 32% kcal, respectively, 1.2 kcal/ml. In all cases, 36% total calories. Both pair‐fed ad libitum fed control groups included. We found that blood levels consistently high three regimens throughout gestation. Alcohol intake...
Children and adults with fetal alcohol spectrum disorder (FASD) have elevated rates of depression anxiety disorders compared to control populations. The effects prenatal exposure (PAE) on anxiety, locomotor activity, hormonal reactivity in male female rats tested the plus maze (EPM), a task commonly used assess anxiety‐like behaviors rodents, were examined. Pregnant dams assigned PAE, pair‐fed (PF), or ad libitum ‐fed (C) groups. At adulthood, half all ( N = 60) PF, C offspring exposed 10...
This two-sequence, three-period crossover study is the first pharmacokinetic (PK) to compare all three innovator formulations of tacrolimus (twice-daily immediate-release capsules [IR-Tac]; once-daily extended-release [ER-Tac]; novel tablets [LCPT]). Stable renal transplant patients were dosed with each drug for 7 days, and blood samples obtained over 24 h. Thirty subjects included in PK analysis set. A conversion factor 1:1:0.80 IR-Tac:ER-Tac:LCPT was used; no dose adjustments permitted...
Fetal alcohol spectrum disorder (FASD) is a developmental that manifests through range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal exposure. Although the North American prevalence currently estimated at 2–5%, FASD has proven difficult to identify in absence overt physical features characteristic fetal syndrome. As interventions may have greatest impact an early age, accurate biomarkers are needed children risk for FASD. Building on our previous...
Abstract The ingestion of ethanol during pregnancy has a number deleterious consequences for the unborn offspring, producing structural and functional deficits that affect brain many other organs into adulthood. hippocampus is area particularly sensitive to ethanol's adverse effects. In previous study we showed voluntary exercise can ameliorate in long‐term potentiation behavior occur following prenatal exposure (Eur J Neurosci, 2005, 21, 1719–1726). present study, investigated effects on...
Abstract There is evidence that the developmental trajectory of cortisol secretion in preterm infants altered, with elevated basal levels observed postnatally through at least 18 months corrected age (CA). This alteration possibly due to neonatal pain‐related stress. High might contribute greater risk impaired neurodevelopment. Since maternal factors are important for regulation infant stress responses, we investigated relationships between (neonatal stress, attention, cortisol) and (stress,...
In this study we investigated the hypothesis that pituitary‐adrenal response inhibition is compromised in animals prenatally exposed to ethanol. first experiment, examined whether opportunity perform a consummatory reduces adrenocortical novel test cage. Animals were water deprived for 24 hr and tested one of three conditions: (a) removed from home cage, blood sample obtained immediately; (b) placed into empty 30 min later; (c) cage with available, later. All showed an increase corticoids...