Data from animal models indicate that neonatal stress or pain can permanently alter subsequent behavioral and/or physiological reactivity to stressors. However, cumulative effects of related acute procedures in the intensive care unit (NICU) on later has received limited attention. The objective this study is examine relationships between prior exposure (number skin breaking procedures), and preterm infants NICU. Eighty-seven were studied at 32 (+/-1 week) postconceptional age (PCA). Infants...

Management of pain in very low birth weight infants is limited by a lack empiric knowledge about the multiple determinants biobehavioral reactivity receiving neonatal intensive care.To examine relationship early factors and previous medication exposure to subsequent acute blood collection.Prospective cohort study. Methods. One hundred thirty-six (</=1500 g) who underwent heel lance for collection at 32 weeks' postconceptional age formed study sample, after excluding those with significant...

Article Abstract Background: Selective serotonin reuptake inhibitor antidepressants (SSRIs) and benzodiazepines are frequently used to treat maternal depression anxiety disorders during pregnancy. Recent reports suggest that prenatal SSRI exposure is associated with a neonatal discontinuation syndrome. It remains unclear whether these symptoms directly related alone or due concurrent pharmacologic factors.Also, this study explores relationships between outcomes medication levels pregnancy,...

Objective. In this prospective study, we examined biobehavioral responses to acute procedural pain at 2 months of age in infants with prenatal and postnatal selective serotonin reuptake inhibitor (SSRI) medication exposure. Based on previous findings showing reduced newborns after exposure, hypothesized that altered reactivity would also be found age. Methods. Facial action (Neonatal Coding System) cardiac autonomic derived from the respiratory activity heart rate variability (HRV) a painful...

To compare biobehavioral responses to acute pain at 4 months' corrected age between former extremely low birth weight (ELBW) infants and term-born controls.Measures of facial behavioral cardiac autonomic reactivity in 21 ELBW (mean = 763 g) were compared with (n 24) during baseline, lance, recovery periods a finger-lance blood collection. Further, painful procedures experienced neonatal care quantified both groups.Overall, the lance similar groups. However, group seemed have less intense...

Aims To compare the disposition of fluoxetine and norfluoxetine enanantiomers in mother, foetus infant. Methods Blood from pregnant women taking ( n = 9), during pregnancy was sampled third trimester at delivery (maternal cord venous blood), infants 48 h after delivery. The subset these who were breastfeeding, plus additional subjects recruited postpartum period, studied further, maternal infant blood, breast milk between 6 days 11 months 23). Drug metabolite concentrations measured using...

Objective The purpose of this study was to explore the capacity for energy production under conditions increased demand in schizophrenia (SCZ) subjects compared healthy controls.Methods Twelve controls (33.00±6.07 years) and 12 diagnosed with SCZ or schizoaffective disorder (36.00±8.33 matched age sex, were recruited study. Hypoxic stress induced during MR scans elevate on subjects’ bioenergetic systems. Participants breathed air a lower oxygen concentration...

Objective. Children with neurologic impairments have shown diminished pain response compared control subjects; however, it remains unclear what mechanisms underlie this or when develops. If were also true premature infants who undergo neonatal intensive care, then parenchymal brain injury (PBI) would be at increased risk of underrecognition and undertreatment procedural pain. The purpose study was to determine whether PBI display altered responses acute 32 weeks’ postconceptional age (PCA),...

Aims: Suicide rates in the general population United States are correlated with altitude. To explore factors contributing to suicide among military veterans, we examined relationship between veteran state-level and altitude for 2014, including firearm-related nonfirearm-related rates. Methods: Pearson's coefficients were calculated each outcome. Mixed linear models used determine association while adjusting demographic confounds. Results: State mean was significantly total rate (r = 0.678, p...

The aim of the study was o determine whether variations exist between races/ethnicities in perineal laceration at first vaginal delivery.We assessed deliveries greater than 35 weeks gestation, for a four-year period, our diverse urban healthcare system. Predictor variable race/ethnicity with outcome none, first-, second-, third-, or fourth-degree laceration. Race and ethnicity were self-reported combined into one to facilitate analysis. We also collected data on other known risk factors...

Major advances have been made in the treatment of childhood cancer; however, survivors cancer are at increased risk for morbidity and mortality. There is little literature regarding available long-term follow-up programs cancer.In March 2007, 16 surveys were sent to pediatric hematology/oncology across Canada determine what cancer, nature such programs.Of 15 participating centers, 13 (87%) multi-disciplinary survivors. Research databases documented 9/15 (60%) centers document late effects....

The violent con£ict that erupted inLibya and toppled theGadda¢ regime in 2011hassigni¢cantly impacted social services the health infrastructure country. in£ux of international humanitarian organisationshas led tomany initiatives tostrengthen mental care psychosocial support for Libyan population. However, with a new fragile government many diierent actors, addition to emerging national initiatives, it was di⁄cult determine who doing what. As result, situation somewhat unclear. On...

Abstract Transient osteoporosis of pregnancy has been described as a rare, self‐limiting disease unclear etiology that presents severe pain, which typically affects pregnant women in their third trimester. We describe 3 cases primigravid with twin gestation who reported unilateral hip pain and were diagnosed transient the by magnetic resonance imaging. These advised to undergo limited weight bearing activity modification minimize risk fracture. Each patient was able proceed through her...

The physical side effects of acutely administered naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg, orally) were compared with placebo in 13 children (3–12 years old) autism. Heart rate, systolic blood pressure, mean arterial axillary body temperature obtained before 1 h after or drug administration. Serum concentrations the liver enzymes glutamic-oxaloacetic transaminase (SGOT) glutamic-pyruvic (SGPT) 24 drug. In comparison placebo, no significant any four doses found on these measures. Three hours...

Introduction: Smoking-related diseases affect 16 million Americans, causing approximately 480,000 deaths annually. The prevalence of cigarette smoking varies regionally across the United States, and previous research indicates that regional rates smoking-related demonstrate a negative association with altitude. purpose this study was to determine relationship between altitude by county (N = 3106) in States. We hypothesized among adults would be negatively associated mean Methods: A...

OBJECTIVE: To evaluate the effect of a structured research curriculum (Clinical Research Education Study Teams [CREST]) on scholarly productivity for residents in obstetrics and gynecology. METHODS: Program records were reviewed each graduate's activity graduating classes 2008–2015 was extracted. A control group consisted who had graduated decade before implementation. Graduates surveyed to determine resident perception their abilities pertaining after graduation. Continued engagement also...