A5071554090- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neuroendocrine regulation and behavior
- Prenatal Substance Exposure Effects
- Pharmacological Effects and Toxicity Studies
- Neuroscience of respiration and sleep
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Assays
- Assisted Reproductive Technology and Twin Pregnancy
- Metabolism and Genetic Disorders
- Infant Development and Preterm Care
- Reproductive Physiology in Livestock
- Analytical Chemistry and Chromatography
- Inflammatory mediators and NSAID effects
- Mass Spectrometry Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Infant Health and Development
- Child and Adolescent Psychosocial and Emotional Development
- Anesthesia and Sedative Agents
University of British Columbia
2011-2021
British Columbia Children's Hospital
1987-2021
Child and Family Research Institute
1998-2019
Family Research Institute
2011-2012
B.C. Women's Hospital & Health Centre
1999-2011
University of British Columbia Hospital
2008
BC Research (Canada)
2000-2007
Beijing Obstetrics and Gynecology Hospital
2005
The University of Adelaide
2005
University of Calgary
2002
Article Abstract Background: Selective serotonin reuptake inhibitor antidepressants (SSRIs) and benzodiazepines are frequently used to treat maternal depression anxiety disorders during pregnancy. Recent reports suggest that prenatal SSRI exposure is associated with a neonatal discontinuation syndrome. It remains unclear whether these symptoms directly related alone or due concurrent pharmacologic factors.Also, this study explores relationships between outcomes medication levels pregnancy,...
Please cite this paper as: von Dadelszen P, Dwinnell S, Magee LA, Carleton BC, Gruslin A, Lee B, Lim KI, Liston RM, Miller SP, Rurak D, Sherlock RL, Skoll MA, Wareing MM, Baker PN, for the Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group. Sildenafil citrate therapy severe early-onset intrauterine growth restriction. BJOG 2011;118:624–628. Currently, there is no effective restriction (IUGR). vasodilates myometrial arteries isolated from women with IUGR-complicated pregnancies....
Objective. In this prospective study, we examined biobehavioral responses to acute procedural pain at 2 months of age in infants with prenatal and postnatal selective serotonin reuptake inhibitor (SSRI) medication exposure. Based on previous findings showing reduced newborns after exposure, hypothesized that altered reactivity would also be found age. Methods. Facial action (Neonatal Coding System) cardiac autonomic derived from the respiratory activity heart rate variability (HRV) a painful...
Aims To compare the disposition of fluoxetine and norfluoxetine enanantiomers in mother, foetus infant. Methods Blood from pregnant women taking ( n = 9), during pregnancy was sampled third trimester at delivery (maternal cord venous blood), infants 48 h after delivery. The subset these who were breastfeeding, plus additional subjects recruited postpartum period, studied further, maternal infant blood, breast milk between 6 days 11 months 23). Drug metabolite concentrations measured using...
We examined the stereoselective disposition of fluoxetine (FX) and its metabolite norfluoxetine (NFX) in five pregnant sheep. Racemic FX was administered i.v. to ewe (50 mg) fetus (10 on separate occasions. Maternal fetal blood, maternal urine, amniotic tracheal fluid samples were collected for 72 h. NFX isomers quantified by gas chromatographymass spectrometry. They rapidly crossed placenta [maternal area under plasma concentration versus time curve (AUC) ratios 0.59 0.65, respectively]....
To determine whether there are changes in blood gas and acid-base status with advancing gestation the fetal lamb, similar to that reported human fetus, gas, acid-base, metabolite values were measured 447 control, arterial samples from 108 chronically instrumented lambs between 103 146 days gestation. With gestation, Po(2), pH, O(2) saturation, content fell significantly, while Pco(2) hemoglobin concentration increased. Blood glucose lactate concentrations unchanged, although level increased...
Term and preterm labor are associated with increased fetal hypothalamic-pituitary-adrenal (HPA) activation synthesis of prostaglandins (PGs) generated through the expression prostaglandin H synthase-II (PGHS-II) in placenta. Inhibition PGHS-II has been advocated as a means producing uterine tocolysis, but effects such treatment on endocrine functions have not thoroughly examined. Because PGE2 is known to activate HPA axis, we hypothesized that administration meloxicam, inhibitor, sheep...
The effects of diphenhydramine on fetal behavioral states, breathing activity, blood gas status, arterial pressure and heart rate have been investigated in the lamb after maternal or drug administration to steady state chronically instrumented pregnant sheep. During infusion there were declines percentage low voltage electrocorticographic (ECoG) pattern 55-46%), ECoG activity containing rapid eye movements (80-55%), overall incidence (42-21%) amount during (67-36%). These sedative like...
The purpose of this study was to examine the disposition diphenhydramine (DPHM) across ovine blood-brain barrier (BBB). In six adult sheep, we characterized central nervous system (CNS) pharmacokinetics DPHM in brain extracellular fluid (ECF) and cerebrospinal (CSF) using microdialysis two experiments. first experiment, administered via a five-step i.v. infusion (1.5, 5.5, 9.5, 13.5, 17.5 μg/kg/min; 7 h per step). Average steady-state CNS/total plasma concentration ratios (i.e., [CNS]/[total...
Plasma hormone and metabolite concentrations have been measured in the plasma of blood collected simultaneously from femoral artery, umbilical vein carotid artery exteriorized foetal sheep. The concentration vasopressin catecholamines was consistently lower glucose, lactate corticosteroids higher compared with artery. ACTH showed no consistent pattern fluctuated widely at each site, but during synacthen infusion than For much that vein; converse true for catecholamines. Concentrations were...