A5103488085- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Neonatal and fetal brain pathology
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Global Maternal and Child Health
- Blood groups and transfusion
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Reproductive Health and Contraception
- Pelvic and Acetabular Injuries
- Parvovirus B19 Infection Studies
- Immune Response and Inflammation
- Hemoglobinopathies and Related Disorders
University of British Columbia
2012-2024
Children's & Women's Health Centre of British Columbia
2006-2022
British Columbia Children's Hospital
2017-2022
McGill University
1987-2022
B.C. Women's Hospital & Health Centre
2005-2021
Medical University of Vienna
2019-2021
Universitätszahnklinik Wien
2021
King Saud University
2017-2019
Public Health Agency of Canada
2019
Karolinska University Hospital
2019
In Brief OBJECTIVE: To examine temporal trends in early-onset compared with late-onset preeclampsia and associated severe maternal morbidity. METHODS: The study included all singleton deliveries Washington State between 2000 2008 (N=670,120). Preeclampsia onset was determined using hospital records linked to birth certificates. Severe morbidity defined as any potentially life-threatening condition. Logistic regression used obtain adjusted odds ratios (aOR) 95% confidence intervals (95% CI)....
<h3>Importance</h3> Although high body mass index (BMI) is associated with adverse birth outcomes, the association severe maternal morbidity unclear. <h3>Objective</h3> To examine between prepregnancy BMI and morbidity. <h3>Design, Setting, Participants</h3> Retrospective population-based cohort study including all singleton hospital births in Washington State, 2004-2013. Demographic data diagnoses were obtained from linked certificates hospitalization files. <h3>Exposures</h3> Prepregnancy...
Please cite this paper as: von Dadelszen P, Dwinnell S, Magee LA, Carleton BC, Gruslin A, Lee B, Lim KI, Liston RM, Miller SP, Rurak D, Sherlock RL, Skoll MA, Wareing MM, Baker PN, for the Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group. Sildenafil citrate therapy severe early-onset intrauterine growth restriction. BJOG 2011;118:624–628. Currently, there is no effective restriction (IUGR). vasodilates myometrial arteries isolated from women with IUGR-complicated pregnancies....
In Brief OBJECTIVE: To conduct a population-based study to assess rates of optimal, suboptimal, and questionably appropriate administration antenatal corticosteroid (betamethasone or dexamethasone) use. METHODS: All live births in Nova Scotia, Canada, from 1988 2012 were included the study. Temporal trends optimal (proportion at 24–34 weeks gestation exposed corticosteroids between 24 hours 7 days before delivery), suboptimal less than more exposure 35 greater corticosteroids) quantified...
To quantify severe perinatal and maternal morbidity/mortality associated with midcavity operative vaginal delivery compared caesarean delivery.Population-based, retrospective cohort study.British Columbia, Canada.Term, singleton deliveries (2004-2014) by attempted or in the second stage of labour, stratified indication for (n = 10 901 deliveries; 5057 indicated dystocia, 5844 fetal distress).Multinomial propensity scores mulitvariable log-binomial regression models were used to estimate...
The ultrasound findings in 132 patients with non-immune hydrops referred for echocardiographic assessment were retrospectively reviewed. Structural was combined evaluation of pleural and pericardial effusions, ascites skin edema. Patients divided into groups based on the underlying etiology hydrops. Seventy found to have cardiac abnormalities, including 45 structural heart disease. Other causes included. chromosomal anomalies, infection, extra-cardiac genetic syndromes and, 40 patients,...
Interleukin-1β (IL-1β) production is impaired in cord blood monocytes. However, the mechanism underlying this developmental attenuation remains unclear. Here, we analyzed extent of variability within Toll-like receptor (TLR)/NLRP3 inflammasome pathways human neonates. We show that immature low CD14 expressing/CD16(pos) monocytes predominate before 33 weeks gestation, and these cells lack pro-IL-1β precursor protein upon LPS stimulation. In contrast, high levels are produced expressing...
The rate of obstetric anal sphincter injury has increased in recent years, particularly among operative vaginal deliveries. We sought to characterize temporal trends episiotomy use and quantify the association between injury.Using a population-based retrospective cohort study design hospital data from 2004 2017, we studied all deliveries singleton infants at term gestation Canada (excluding Quebec). Rates were contrasted women who had an those did not. Log-binomial regression was used...
Competency based medical education is developed utilizing a program of assessment that ideally supports learners to reflect on their knowledge and skills, allows them exercise growth mindset prepares for coaching eventual lifelong learning, can support important progression certification decisions. Examinations serve as an anchor assessment, particularly when considering strength independent, third-party with evidence they predict future physician performance patient outcomes. This paper...
BACKGROUND This study investigated the effects of impairment to placental flow on patterns through aortic isthmus because in fetus, this vascular segment is link between parallel systems perfused by left and right ventricles. METHODS AND RESULTS A progressive increase resistance blood placenta was created seven exteriorized fetal lambs mechanical umbilical vein compression. Blood flows were measured ascending aorta, pulmonary artery, isthmus, artery at baseline each compression level. The...
Although the role of PGE 2 in maintaining ductus arteriosus (DA) patency is well established, specific receptor subtype(s) (EP) involved have not been clearly identified. We used late gestation fetal and neonatal lambs to study developmental regulation EP receptors. In DA, radioligand binding RT-PCR assays virtually failed detect 1 but detected , 3D 4 receptors equivalent proportions. newborn lamb, DA total density was one-third that found fetus only detected. Stimulation increased cAMP...
<h3>BACKGROUND:</h3> Increased use of operative vaginal delivery (i.e., forceps or vacuum application), which 20% occurs at midpelvic station, has been advocated to reduce the rate cesarean delivery. We aimed quantify severe perinatal and maternal morbidity mortality associated with attempted <h3>METHODS:</h3> studied all term singleton deliveries in Canada between 2003 2013, by labour (with without prolonged second stage). The primary outcomes were composite (e.g., convulsions, assisted...
This study sought to quantify perinatal and maternal morbidity mortality associated with forceps vacuum delivery compared Caesarean in the second stage of labour estimate whether these associations differed by pelvic station.The investigators conducted a population-based, retrospective cohort term singleton deliveries operative prolonged Canada (2003-2013) using national hospitalization data. The primary outcomes were severe (i.e., seizures, assisted ventilation, birth trauma, death)...
<b><i>Background:</i></b> Preterm neonates are highly vulnerable to infection. <b><i>Objectives:</i></b> To investigate the developmental contribution of prematurity, chorioamnionitis and antenatal corticosteroids (ANS) on maturation neonatal microbial pathogen recognition responses. <b><i>Methods:</i></b> Using standardized protocols, we assayed multiple inflammatory cytokine responses (IL-1β, IL-6, TNF-α IL-12/23p40)...
Abstract A range‐gated Doppler ultrasound system combined with a real‐time imaging was used to determine arterial blood velocity values from the fetal and placental ends of umbilical cord in 269 normal pregnancies between 17 40 weeks, menstrual age. The systolic–diastolic ratio (S/D), pulsatility index (PI), resistance (RI) were higher at end compared cord. individual differences these indices, obtained recording sites, inversely related age: S/D: r = −0.38, p < 0.001; PI: −0.25, RI:...
Please cite this paper as: Hutcheon J, Butler B, Lisonkova S, Marquette G, Mayer C, Skoll A, Joseph K. Timing of delivery for pregnancies with congenital diaphragmatic hernia. BJOG 2010;117:1658–1662. A recent report has suggested that at early term ages may be associated lower mortality among infants We sought to confirm finding by examining gestational age‐specific in the USA isolated hernia, delivered following spontaneous onset labour. In final population 928 infants, neonatal and infant...
OBJECTIVE: To estimate the accuracy of a new assay to determine fetal RHD status using circulating cell-free DNA. METHODS: This was prospective, observational study. Maternal blood samples were collected in each trimester pregnancy 520 nonalloimmunized RhD-negative patients. Plasma analyzed for DNA SensiGENE test, which used primers exons 4 and 7 as previously described incorporated primer design exon 5 gene. Neonatal serology RhD typing cord at birth undertaken results stored separate...