A5102020746- Innovative Microfluidic and Catalytic Techniques Innovation
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- Probiotics and Fermented Foods
- Electrohydrodynamics and Fluid Dynamics
- Electrowetting and Microfluidic Technologies
- Infective Endocarditis Diagnosis and Management
- Nanowire Synthesis and Applications
- Graphene research and applications
- Microfluidic and Bio-sensing Technologies
- SARS-CoV-2 detection and testing
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Inflammasome and immune disorders
- Prosthetics and Rehabilitation Robotics
- Lower Extremity Biomechanics and Pathologies
- Antibiotic Use and Resistance
- Escherichia coli research studies
- Neonatal and Maternal Infections
- Kawasaki Disease and Coronary Complications
- Anesthesia and Neurotoxicity Research
- Advanced Biosensing Techniques and Applications
- Advanced Drug Delivery Systems
- Electrical and Bioimpedance Tomography
King Abdullah University of Science and Technology
2021-2023
AbbVie (United States)
2023
University of Massachusetts Amherst
2020-2022
Sharma & Associates (United States)
2020
Punjab Technical University
2020
Augusta University
2020
Ulsan National Institute of Science and Technology
2018-2019
Indian Institute of Technology Indore
2018
Indian Institute of Technology Guwahati
2014-2015
Child and Family Research Institute
2014
Abstract Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate regulator flhDC drive invasion and (2) induce lysis release proteins into tumor cells. Released protein drugs diffuse from Salmonella containing vacuoles cellular cytoplasm where they interact with their therapeutic targets....
Interleukin-1β (IL-1β) production is impaired in cord blood monocytes. However, the mechanism underlying this developmental attenuation remains unclear. Here, we analyzed extent of variability within Toll-like receptor (TLR)/NLRP3 inflammasome pathways human neonates. We show that immature low CD14 expressing/CD16(pos) monocytes predominate before 33 weeks gestation, and these cells lack pro-IL-1β precursor protein upon LPS stimulation. In contrast, high levels are produced expressing...
This research work has been completed by concentrating on the structure of inserts for foot orthosis fabricated utilizing rapid prototyping technology. Thermoplastic elastomer and thermoplastic polyurethane are most commonly used materials that being in customized three-dimensional printed orthotic insoles, which comfortable prevent user many disorders. Thermo-softening viscoelastic polymers, explicitly Filaflex Ninjaflex, have Flash Forge printers to evaluate mechanical properties specimens...
Abstract Cardiac troponin T (cTnT) is considered a clinical standard for its high specificity and sensitivity when diagnosing acute myocardial infarction; however, most studies on the electrical sensors of cardiac biomarkers have focused cTnI rather than cTnT. This study presents label-free, low-cost, transparent, flexible aptamer-based immunosensors detection cTnT using reduced graphene oxide (rGO) sheets. GO was first deposited by AC dielectrophoresis between two predefined source drain...
Dysfunction of the intestinal mucus barrier causes disorders such as ulcerative colitis and Crohn's disease. The function this essential may be affected by periodically changing luminal environment. We hypothesized that pH ion concentration in control its porosity, molecular permeability, penetration microbes. To test hypothesis, we developed a scalable method to extract porcine small (PSIM). aggregation porosity PSIM were determined using rheometry, spectrophotometry, microscopy....
Dielectrophoresis (DEP) is usually effective close to the electrode surface. Several techniques have been developed overcome its drawbacks and enhance dielectrophoretic particle capture. Here we present a simple technique of superimposing alternating current DEP (high-frequency signals) electroosmosis (EO; low-frequency between two coplanar electrodes (gap: 25 μm) using lab-made voltage adder for rapid selective concentration bacteria, viruses, proteins, where controlled voltages frequencies...
Solid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining upscalable manufacturing with the required performance remains challenging. Here, an alternative biosensor concept is developed, which relies on a solution-processed In2 O3 /ZnO semiconducting heterojunction featuring geometrically engineered tri-channel architecture rapid, real-time detection of important biomolecules. The sensor combines...
Strategic application of external electrostatic field on a pressure-driven two-phase flow inside microchannel can transform the stratified or slug patterns into droplets. The localized electrohydrodynamic stress at interface immiscible liquids engender liquid-dielectrophoretic deformation, which disrupts balance viscous, capillary, and inertial forces to such morphologies. Interestingly, size, shape, frequency droplets be tuned by varying intensity, location electric field, surface...
An externally applied alternating current (AC) electrostatic field can deform the interface of a pair weakly conducting liquids to engender droplet flow patterns inside ‘T’ shaped microchannels.
The balance of microbial species in the intestine must be maintained to prevent inflammation and disease. Healthy bacteria suppress infection by pathogens disorders such as inflammatory bowel diseases (IBDs). role mucus relation between intestinal microbiota is poorly understood. Here, we hypothesized that healthy inhibit preventing from penetrating layer imbalance leads promoting penetration mucosal barrier. We tested this hypothesis with an vitro model contains mucus, epithelial cell...
This paper presents design, development and different optimal control strategies for a spiral, shape memory alloy (SMA) actuators robotics applications. The actuator material used is thermally activated Ni-Ti SMA which exhibits high torque capacity. based are widely in applications because of their large energy density super-elasticity. Here describe the multi-direction movement soft robot on actuators. To controlling precise position minimum time suitable controller require. we investigated...
Microphysiological systems (MPS) incorporating human intestinal organoids have shown the potential to faithfully model biology with promise accelerate development of oral prodrugs. We hypothesized that an MPS flow, shear stress, and vasculature could provide more reliable measures prodrug bioconversion permeability. Following construction jejunal duodenal organoid derived from 3 donors, we determined area under concentration-time (AUC) curve for active drug in vascular channel characterized...
The mucosal barrier in combination with innate immune system are the first line of defense against luminal bacteria at intestinal mucosa. Dysfunction mucus layer and bacterial infiltration linked to tissue inflammation disease. To study host-bacterial interactions interface, we created an experimental model that contains space, a layer, epithelial suspended cells. Reconstituted porcine small formed 880 ± 230 µm thick gel had porous structure. In presence mucus, sevenfold less probiotic...
Neonatal endocarditis is a rare and usually fatal disease. The diagnosis difficult because the criteria that have suggested used in adults are not readily applicable. We report neonate having multiple congenital anomalies with co-infected bacterial fungal successful medical treatment.
Abstract Solid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining cost-effective manufacturing with high sensitivity, specificity and fast sensing response, remains challenging. Here we develop low-temperature solution-processed In 2 O 3 /ZnO heterojunction transistors featuring a geometrically engineered tri-channel architecture rapid real-time detection of different biomolecules. The sensor...