A5047267991- Inhalation and Respiratory Drug Delivery
- Particle Dynamics in Fluid Flows
- Infection Control and Ventilation
- Aerosol Filtration and Electrostatic Precipitation
- Healthcare and Environmental Waste Management
- Asthma and respiratory diseases
- COVID-19 and healthcare impacts
- Advancements in Transdermal Drug Delivery
- Airway Management and Intubation Techniques
- Virus-based gene therapy research
- Cancer Research and Treatments
- Advanced Drug Delivery Systems
- Catalytic Processes in Materials Science
- RNA Interference and Gene Delivery
- Cyclone Separators and Fluid Dynamics
- Infection Control in Healthcare
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Environmental and Sediment Control
University of Delaware
2019-2023
University of Massachusetts Amherst
2021
Abstract Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate regulator flhDC drive invasion and (2) induce lysis release proteins into tumor cells. Released protein drugs diffuse from Salmonella containing vacuoles cellular cytoplasm where they interact with their therapeutic targets....
Background: Delivery of aerosols to isolated lobes the lungs would be beneficial for diseases that have lobe-specific effects, such as cancer, pneumonia, and chronic obstructive pulmonary disorder. Recent computational fluid-particle dynamic (CFPD) modeling has demonstrated in low flow rates, inlet location a particle at mouth dictates lobe into which it will deposit. However, realization this deposition yet attempted experimentally or clinic. To address this, we sought develop...
Current facemask research focuses on material characterization and efficiency; however, facemasks are often not tested such that aerosol distributions evaluated from the gaps in sides, bottom, nose areas. Poor evaluation methods could lead to misinformation optimal use; a high-throughput, reproducible method which illuminates issue of fit influencing transmission is needed. To this end, we have created an vitro model quantify particle by mimicking exhalation aerosols 3D printed...
Abstract The airway of pediatric patients’ changes through development, presenting a challenge in developing pediatric-specific aerosol therapeutics. Our work aims to quantify geometric variations and deposition patterns during upper development subjects between 3.5 months–6.9 years old using library 24 models 4 adult models. Computational fluid–particle dynamics was performed with varying particle size (0.1–10 μm) flow rate (10–120 Lpm), which rigorously analyzed compare anatomical metrics...
Development of targeted therapies for pulmonary diseases is limited by the availability preclinical testing methods with ability to predict regional aerosol delivery. Leveraging 3D printing generate patient-specific lung models, we outline design a high-throughput, in vitro experimental setup quantifying lobular deposition. This system made combination commercially available and printed components allows flow rate through each lobe be independently controlled. Delivery fluorescent aerosols...
Nanoparticle evaluation within the pulmonary airspace has increasingly important implications for human health, with growing interest from drug delivery, environmental, and toxicology fields. While there have been widespread investigations of nanoparticle physiochemical properties following many routes administration, behavior at air-liquid interface (ALI) is less well-characterized. In this work, we fabricate two formulations poly(ethylene)-glycol diacrylate (PEGDA)-based model...
Abstract This study focuses on the transport, deposition, and triggered immune response of intranasal vaccine droplets to Angiotensin-converting enzyme 2-rich region (i.e., olfactory (OR)) in nasal cavity a 6-year-old female possibly prevent COVID-19. To investigate how administration strategy can influence efficiency, validated multiscale model computational fluid-particle dynamics (CFPD) host-cell (HCD) model) was employed. Droplet deposition fraction, size change, residence time, area...
Development of targeted therapies for pulmonary diseases is limited by the availability preclinical testing methods with ability to predict regional aerosol delivery. Leveraging 3D printing generate patient-specific lung models, we outline design a high-throughput, in vitro experimental setup quantifying lobular deposition. This system made combination commercially available and printed components allows flow rate through each lobe be independently controlled. Delivery fluorescent aerosols...