A5078749346- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Pediatric Pain Management Techniques
- Congenital Heart Disease Studies
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Infant Nutrition and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Family and Disability Support Research
- Neonatal and Maternal Infections
- Child and Adolescent Health
- Pregnancy and preeclampsia studies
- Multiple Sclerosis Research Studies
- Infant Health and Development
- Cerebral Palsy and Movement Disorders
- Neonatal Health and Biochemistry
- Functional Brain Connectivity Studies
- Acute Kidney Injury Research
- Maternal and Perinatal Health Interventions
- Anesthesia and Neurotoxicity Research
- Pregnancy and Medication Impact
- Advanced Neuroimaging Techniques and Applications
University of British Columbia
2016-2025
British Columbia Children's Hospital
2016-2025
B.C. Women's Hospital & Health Centre
2015-2024
University of Toronto
2013-2024
Hospital for Sick Children
2013-2024
Colorado Kidney Care
2024
Vancouver Biotech (Canada)
2001-2024
Western University
2020-2023
SickKids Foundation
2013-2023
Mount Sinai Hospital
2013-2023
Abstract Objective: Preterm infants are exposed to multiple painful procedures in the neonatal intensive care unit (NICU) during a period of rapid brain development. Our aim was examine relationships between procedural pain NICU and early development very preterm infants. Methods: Infants born (N = 86; 24–32 weeks gestational age) were followed prospectively from birth, studied with magnetic resonance imaging, 3‐dimensional spectroscopic diffusion tensor imaging: scan 1 life (median, 32.1...
Background. Previous reports of variations in outcomes among neonatal intensive care units (NICUs) examined only specific subpopulations interest (eg, very low birth weight [VLBW] infants <1500 g [BW]). Objectives. We report on current practice and a population-based national study Canadian NICUs from January 8, 1996 to October 31, 1997. Method. Information 20 488 admissions 17 tertiary level across Canada was prospectively collected by trained abstractors using standard manual...
Procedural pain in the neonatal intensive care unit triggers a cascade of physiological, behavioral and hormonal disruptions which may contribute to altered neurodevelopment infants born very preterm, who undergo prolonged hospitalization at time physiological immaturity rapid brain development. The aim this study was examine relationships between cumulative procedural (number skin-breaking procedures from birth term, adjusted for early illness severity overall intravenous morphine...
BACKGROUND: Neurodevelopmental disability is the most common complication for survivors of surgery congenital heart disease (CHD). METHODS: We analyzed individual participant data from studies children evaluated with Bayley Scales Infant Development, second edition, after cardiac between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), secondary Mental (MDI). RESULTS: Among 1770 subjects 22 institutions, assessed at age 14.5 ± 3.7 months, PDIs MDIs (77.6 18.8 88.2...
Background Altered brain development is evident in children born very preterm (24–32 weeks gestational age), including reduction gray and white matter volumes, thinner cortex, from infancy to adolescence compared term-born peers. However, many questions remain regarding the etiology. Infants are exposed repeated procedural pain-related stress during a period of rapid development. In this vulnerable population, we have previously found that neonatal associated with atypical birth...
Children born very prematurely (< or =32 weeks) often exhibit visual-perceptual difficulties at school-age, even in the absence of major neurological impairment. The alterations functional brain activity that give rise to such problems, as well relationship between adverse neonatal experience and neurodevelopment, remain poorly understood. Repeated procedural pain-related stress during intensive care has been proposed contribute altered neurocognitive development these children. Due critical...
<h3>Importance</h3> Excessive antibiotic use has been associated with altered bacterial colonization and may result in resistance, fungemia, necrotizing enterocolitis (NEC), mortality. Exploring the association between exposure neonatal outcomes other than infection-related morbidities provide insight on importance of rational use, especially setting culture-negative sepsis. <h3>Objective</h3> To evaluate trend among all hospitalized very low-birth-weight (VLBW) infants across Canada rates...
Very preterm infants (born 24-32 weeks' gestation) undergo numerous invasive procedures during neonatal care. Repeated skin-breaking in rodents cause neuronal cell death, and human neonates higher numbers of from birth to term-equivalent age are associated with abnormal brain development, even after controlling for other clinical risk factors. It is unknown whether long-term alterations microstructure cognitive outcome at school children born very preterm.Fifty underwent MRI testing median...
Identify determinants of neurodevelopmental outcome in preterm children.Prospective national cohort study children born between 2009 and 2011 at <29 weeks gestational age, admitted to one 28 Canadian neonatal intensive care units assessed a Neonatal Follow-up Network site 21 months corrected age for cerebral palsy (CP), visual, hearing developmental status using the Bayley Scales Infant Toddler Development-Third Edition (Bayley-III). Stepwise regression analyses evaluated effect (1) prenatal...
Very preterm human neonates are exposed to numerous invasive procedures as part of life-saving care. Evidence suggests that repetitive neonatal procedural pain precedes long-term alterations in brain development. However, date the link between and development has limited temporal anatomic specificity. We hypothesized early exposure painful stimuli during a period rapid development, before modulatory systems reach maturity, will predict pronounced changes thalamic thereby cognitive motor...
KEY POINTS Congenital diaphragmatic hernia (CDH), which occurs in about 1 3300 live births, is a congenital defect the diaphragm that allows herniation of abdominal viscera into thorax.[1][1] The resulting abnormal lung development leads to pulmonary hypoplasia and hypertension,
<h3>Objective:</h3> Our objective was to determine the association of early brain maturation with neurodevelopmental outcome in premature neonates. <h3>Methods:</h3> Neonates born between 24 and 32 weeks’ gestation (April 2006 August 2010) were prospectively studied MRI life again at term-equivalent age. Using diffusion tensor imaging magnetic resonance spectroscopic imaging, fractional anisotropy (FA) (microstructure) <i>N</i>-acetylaspartate (NAA)/choline (metabolism) measured from basal...
<h3>Importance</h3> Studies of socioeconomic status and neurodevelopmental outcome in very preterm neonates have not sensitively accounted for brain injury. <h3>Objective</h3> To determine the association injury maternal education with motor cognitive outcomes at age 4.5 years neonates. <h3>Design, Setting, Participants</h3> Prospective cohort study (24-32 weeks’ gestation) recruited August 16, 2006, to September 9, 2013, British Columbia Women's Hospital Vancouver, Canada. Analysis 4.5-year...
Impaired growth during neonatal intensive care is associated with delayed microstructural development of the cortical gray matter after accounting for prenatal growth, illness, and brain injury in infants born very preterm.
Abstract Objective The association of chorioamnionitis and noncystic white matter injury, a common brain injury in premature newborns, remains controversial. Our objectives were to determine the postnatal risk factors with effects on early development, using advanced magnetic resonance imaging. Methods Ninety‐two preterm newborns (24–32 weeks gestation) studied at median age 31.9 again 40.3 gestation. Histopathological scored validated systems. Measures metabolism (N‐acetylaspartate/choline...
Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; it unknown whether neonatal pain-related affects growth preterm. The aim of this study was examine greater (number skin-breaking procedures adjusted for medical confounders) related decreased (weight and head circumference [HC] percentiles) life at...
Objective Very preterm‐born neonates (24–32 weeks of gestation) are exposed to stressful and painful procedures during neonatal intensive care. Analgesic sedation therapies essential, opiates benzodiazepines commonly used. These medications may negatively impact brain development. The hippocampus be especially vulnerable the effects pain analgesic and/or sedative contribute adverse outcomes. effect invasive analgesic–sedative exposure on hippocampal growth was assessed, as that...