A5076373651- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Congenital heart defects research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Muscle Physiology and Disorders
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Inflammasome and immune disorders
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Neonatal Respiratory Health Research
Sanno Medical Center
2021-2025
International University of Health and Welfare
2019-2024
University of Toyama
2012-2021
Juntendo University
2021
Toyama University Hospital
1999-2019
Ono Pharmaceutical (Japan)
2018
Medtronic (Japan)
2018
Japanese Circulation Society
2017
Toho University
2016
Toho University Omori Medical Center
2016
Background —Mutations in the gene G4.5 result a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose this study was to investigate patients LVNC or BTHS for mutations other novel genes. Methods and Results —DNA from 2 families 3 individuals congenital heart disease (CHD), 4 associated DCM, screened by single-strand DNA conformation polymorphism...
BACKGROUND: Neurodevelopmental disability is the most common complication for survivors of surgery congenital heart disease (CHD). METHODS: We analyzed individual participant data from studies children evaluated with Bayley Scales Infant Development, second edition, after cardiac between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), secondary Mental (MDI). RESULTS: Among 1770 subjects 22 institutions, assessed at age 14.5 ± 3.7 months, PDIs MDIs (77.6 18.8 88.2...
The prevalence of congenital long QT syndrome (LQTS) (1 : 2,000) is based on genetic testing and ECG data, but the electrocardiographically determined prolonged corrected interval (pQTc) in infants unclear. Subjects were 10,282 1-month-old who participated 2 prospective screening studies performed 2010-2011 2014-2016. Infants with a QTc ≥0.45 using Bazett's formula [QTc(B)] at 1-month medical checks re-examined. pQTc was defined as ≥0.46 different ECGs early infancy. ≥0.50 or progressive...
Hypertrophic cardiomyopathy (HCM), which is inherited as an autosomal dominant trait, the most prevalent hereditary cardiac disease. Although there are several reports on systematic screening of mutations in disease-causing genes European and American populations, only limited information available for Asian including Japanese.Genetic disease-associated 8 sarcomeric proteins, MYH7, MYBPC3, MYL2, MYL3, TNNT2, TNNI3, TPM1, ACTC, was performed by direct sequencing 112 unrelated Japanese proband...
Background:The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery acute or fulminant myocarditis (AMC/FMC) in children revealed that survival rate FMC was only 51.6%. The 2nd performed to evaluate recent outcomes pediatric myocarditis.
Background Left ventricular noncompaction ( LVNC ) has since been classified as a primary genetic cardiomyopathy, but the basis is not fully evaluated. The aim of present study was to identify spectrum using next‐generation sequencing and evaluate genotype–phenotype correlations in patients. Methods Results Using sequencing, we targeted sequenced 73 genes related cardiomyopathy 102 unrelated We identified 43 pathogenic variants 16 39 patients (38%); 28 were novel variants. Sarcomere gene...
Kawasaki disease (KD) is an acute vasculitis of childhood, predominantly affecting the coronary arteries. S100A12, a granulocyte-derived agonist both receptor for advanced glycation end products (RAGE) and Toll-like 4 (TLR-4), strongly up-regulated in KD. This study was undertaken to investigate potential contributions S100A12 pathogenesis KD.Serum samples from patients with KD (n = 30) at different stages pre- post-intravenous immunoglobulin (IVIG) treatment were analyzed expression...
Fontan-associated liver disease (FALD) is an important late complication involving dysfunction, such as cirrhosis (LC) and hepatocellular carcinoma (HCC), in patients undergoing the Fontan procedure. However, prevalence, clinical manifestation, methods of diagnosis FALD are still not well established.Methods Results:This study comprised 2 nationwide surveys Japan. First, prevalence LC and/or HCC procedure was determined. Second, manifestations with were analyzed, along data from blood tests,...