A5014884266- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Adolescent and Pediatric Healthcare
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Kawasaki Disease and Coronary Complications
- Spondyloarthritis Studies and Treatments
- Otitis Media and Relapsing Polychondritis
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Urticaria and Related Conditions
- Bone health and osteoporosis research
- Bacterial Infections and Vaccines
- Musculoskeletal Disorders and Rehabilitation
- Inhalation and Respiratory Drug Delivery
- Eosinophilic Esophagitis
- Infectious Diseases and Tuberculosis
- Bacterial biofilms and quorum sensing
- Adenosine and Purinergic Signaling
- Bone and Joint Diseases
University of British Columbia
2016-2025
British Columbia Children's Hospital
2016-2025
Polytechnic Institute of Bragança
2022
Digital Research Alliance of Canada
2019
University of Pittsburgh
2018
Neurological Surgery
2018
University of Ottawa
2012-2015
Roche (United Kingdom)
2015
Royal National Hospital for Rheumatic Diseases
2015
Bristol Royal Hospital for Children
2015
<h3>Objective</h3> To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective inception cohort children managed with contemporary treatments. <h3>Methods</h3> Children newly diagnosed JIA at 16 Canadian paediatric rheumatology centres from 2005 to 2010 were included. Kaplan–Meier survival curves for each category used estimate probability ever attaining an active joint count 0, inactive disease (no joints, no extraarticular manifestations and physician global...
To report methodology and overall clinical, laboratory radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) c-Takayasu arteritis (c-TA) classification criteria.The preliminary Vienna 2005 consensus conference, which proposed criteria paediatric vasculitides, was followed by a EULAR/PRINTO/PRES - supported validation project divided into three main steps. Step 1: retrospective/prospective web-data collection...
Abstract Objective To compare the criteria for Wegener's granulomatosis (WG) of American College Rheumatology (ACR) with those European League Against Rheumatism/Pediatric Society (EULAR/PRES) in a cohort children WG and other antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs), to describe interval diagnosis, presenting features, initial treatment WG. Methods Eligible patients had been diagnosed by site rheumatologists (termed “MD diagnosis”) since 2004. This diagnosis...
<h3>Background</h3> Rare chronic childhood vasculitides lack a reliable disease activity assessment tool. With emerging new treatment modalities such tool has become increasingly essential for both clinical practice and therapeutic trials to reproducibly quantify change in state. <h3>Objective</h3> To develop validate paediatric vasculitis based on modification of the Birmingham Vasculitis Activity Score (BVASv.3). <h3>Methods</h3> A registry was reviewed identify features missing BVASv.3....
Abstract Objective Vertebral fractures are an under‐recognized problem in children with inflammatory disorders. We studied spine health among 134 (87 girls) rheumatic conditions (median age 10 years) within 30 days of initiating glucocorticoid therapy. Methods Children were categorized as follows: juvenile dermatomyositis (n = 30), idiopathic arthritis 28), systemic lupus erythematosus and related 26), 22), vasculitis 16), other 12). Thoracolumbar radiograph dual x‐ray absorptiometry for...
To determine the frequency of incident vertebral fractures (IVF) 12 months after glucocorticoid (GC) initiation in children with rheumatic diseases and to identify at higher risk.Children initiating GC were enrolled a prospective observational study. Annual spine radiographs evaluated using Genant semiquantitative method. Spine areal bone mineral density (aBMD) was measured every 6 months. Clinical features, including cumulative dose, back pain, disease physical activity, calcium vitamin D...
Objective To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison patients granulomatosis (Wegener's) (GPA). Methods The European Medicines Agency (EMA) classification algorithm was applied by computation categorical data from recruited the ARChiVe (A Registry for Childhood Vasculitis: e‐entry) cohort, censored November 2015. EMA used distinguish MPA GPA, whose...
Vertebral fractures due to osteoporosis are a potential complication of childhood acute lymphoblastic leukemia (ALL). To date, the incidence vertebral during ALL treatment has not been reported.We prospectively evaluated 155 children with first 12 months therapy. Lateral thoracolumbar spine radiographs were obtained at baseline and months. bodies assessed for incident using Genant semiquantitative method, relevant clinical indices such as bone mineral density (BMD), back pain, presence...
Vertebral fractures are an important yet underrecognized manifestation of osteoporosis in children with chronic, glucocorticoid-treated illnesses. Our goal was to determine the incidence and clinical predictors vertebral 3 years following glucocorticoid initiation among pediatric patients rheumatic disorders. Incident were evaluated according Genant semiquantitative method on lateral radiographs at baseline then annually initiation. Extended Cox models used assess association between risk...
Abstract Objective To evaluate features during the first 6 months of disease that may be associated with a poor outcome as measured principally by extension to polyarticular course in patients oligoarticular‐onset juvenile rheumatoid arthritis (oligo‐JRA). Methods This study was retrospective review who fulfilled American College Rheumatology criteria for oligo‐JRA, were followed up at least 5 years, and did not have psoriatic arthritis, spondylarthropathy‐like disease, or factor positivity....
Abstract Objective To determine early outcomes and improvements in a prospective inception cohort of children with juvenile idiopathic arthritis (JIA) treated current standard therapies. Methods Patients selected were enrolled an JIA, the Research Arthritis Canadian Children Emphasizing Outcomes Study. The rheumatoid core criteria set measures completed at enrollment 6 months later. Frequencies normal values for each American College Rheumatology (ACR) Pediatric 30, 50, 70 (Pedi 70) response...
<h3>Objective</h3> To describe probabilities and characteristics of disease flares in children with juvenile idiopathic arthritis (JIA) to identify clinical features associated an increased risk flare. <h3>Methods</h3> We studied the Research Arthritis Canadian Children emphasizing Outcomes (ReACCh-Out) prospective inception cohort. A flare was defined as a recurrence manifestations after attaining inactive called significant if it required intensification treatment. Probability first...
To characterize the early disease course in childhood-onset antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and 12-month outcomes children with AAV.Eligible subjects were entered into Pediatric Vasculitis Initiative study who diagnosed before their eighteenth birthday as having granulomatosis polyangiitis (Wegener's), microscopic polyangiitis, eosinophilic (Churg-Strauss), or ANCA-positive pauci-immune glomerulonephritis. The primary outcome measure was achievement of...
Kawasaki disease (KD) is an acute vasculitis of childhood, predominantly affecting the coronary arteries. S100A12, a granulocyte-derived agonist both receptor for advanced glycation end products (RAGE) and Toll-like 4 (TLR-4), strongly up-regulated in KD. This study was undertaken to investigate potential contributions S100A12 pathogenesis KD.Serum samples from patients with KD (n = 30) at different stages pre- post-intravenous immunoglobulin (IVIG) treatment were analyzed expression...
Abstract Objective To determine early predictors of 6‐month outcomes in a prospective cohort patients with juvenile idiopathic arthritis (JIA). Methods Patients selected were those enrolled an inception study JIA, the Research Arthritis Canadian Children Emphasizing Outcomes Study, within 6 months after diagnosis. The rheumatoid core criteria set and quality life measures collected at enrollment later. evaluated included inactive disease, Juvenile Quality Life Questionnaire (JAQQ) scores,...