A5062062002- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- T-cell and B-cell Immunology
- interferon and immune responses
- Acute Lymphoblastic Leukemia research
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Mechanical Circulatory Support Devices
- Atherosclerosis and Cardiovascular Diseases
- Wnt/β-catenin signaling in development and cancer
- Drug-Induced Adverse Reactions
- Immune Response and Inflammation
- Retinal and Optic Conditions
- Inflammatory Myopathies and Dermatomyositis
- Family Support in Illness
- Celiac Disease Research and Management
- Ocular Diseases and Behçet’s Syndrome
- Childhood Cancer Survivors' Quality of Life
- Connective tissue disorders research
Texas Scottish Rite Hospital for Children
2014-2024
The University of Texas Southwestern Medical Center
2012-2024
Children's Medical Center
2023-2024
Duke University
2024
University of Alabama at Birmingham
2022
Alberta Children's Hospital
2021
University of Calgary
2021
University of California, San Francisco
2021
Southwestern Medical Center
2012-2016
Pediatrics and Genetics
2014
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, activity (DA), nephritis class, confirmed a prevalent IFN signature identified plasmablast as most robust biomarker DA. We detected gradual...
Abstract Objective To compare the criteria for Wegener's granulomatosis (WG) of American College Rheumatology (ACR) with those European League Against Rheumatism/Pediatric Society (EULAR/PRES) in a cohort children WG and other antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs), to describe interval diagnosis, presenting features, initial treatment WG. Methods Eligible patients had been diagnosed by site rheumatologists (termed “MD diagnosis”) since 2004. This diagnosis...
Abstract Blood monocytes from children with systemic lupus erythematosus (SLE) behave similar to dendritic cells (DCs), and SLE serum induces healthy differentiate into DCs in a type I IFN–dependent manner. In this study, we found that these display significant transcriptional changes, including prominent IFN signature, compared controls. Few of those however, explain DC function. Exposure allogeneic T vitro reprograms acquire phenotype function, correlates both IFN-inducible (IP10)...
Objective. Granulomatosis with polyangiitis (Wegener’s; GPA) and other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare in childhood sometimes difficult to discriminate. We compared use of adult-derived classification schemes for GPA against validated pediatric criteria the ARChiVe (A Registry Childhood Vasculitis e-entry) cohort, a Arthritis Rheumatology Research Alliance initiative. Methods. Time-of-diagnosis data children physician (MD) diagnosis AAV...
Objective. There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid tool adult Version 3 (BVAS v.3) correlates well with physician’s global assessment (PGA), treatment decision, and C-reactive protein adults. utility of BVAS v.3 vasculitis not known. We assessed the association scores PGA, erythrocyte sedimentation rate (ESR) at diagnosis antineutrophil cytoplasmic antibody-associated (AAV). Methods....
This study was undertaken to identify blood markers of juvenile dermatomyositis (DM) disease activity (DA), which are needed improve management.The comprised a total 123 DM patients and 53 healthy controls. Results laboratory tests (aldolase, creatinine kinase, lactate dehydrogenase [LDH], aspartate aminotransferase) clinical measures DA in with DM, including the Manual Muscle Testing 8 muscles (MMT-8), Childhood Myositis Assessment Scale (CMAS), scores (DAS) (total DAS for muscle DAS, skin...
Systemic Lupus Erythematosus (SLE) is characterized by autoreactive B cell activation, upregulation of Type I Interferon (IFN) and widespread inflammation. Mitochondrial nucleic acids (NAs) are increasingly recognized as triggers IFN 1 . Thus, defective removal mitochondria from mature red blood cells (Mito + RBCs), a feature SLE, contributes to production myeloid 2 Here we identify monocytes (Mo) that have internalized RBCs co-express IFN-stimulated genes (ISGs) interleukin-1β (IL-1β) in...
The treatment of children with multisystem inflammatory syndrome in (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 receptor inhibitor, has also been used, but its effectiveness is not established yet. As optimal regimens for MIS-C remain unknown, we aimed assess the effect anakinra reducing hospital stay patients MIS-C.We included admitted from May 2020 2021 diagnosed based on CDC criteria. exposure interest...
Coping mechanisms and emotional regulation are important contributors to psychosocial health during stressful life events. We sought describe the coping responses of persons with childhood-onset systemic lupus erythematosus transfer from pediatric adult healthcare.Semi-structured in-depth one-on-one interviews were conducted 13 young women aged 18-24 minority background who had transferred care in a public hospital system. Thematic analysis was used identify themes motifs data.Participants...
Abstract Background The psychosocial burden of having a chronic disease can be substantial for adolescents with childhood-onset systemic lupus erythematosus (cSLE). Current literature is scarce on interventions that improve outcomes this population. Therapeutic recreation camps have been proposed as beneficial experience chronically ill pediatric populations. However, their effective components not well characterized in patients cSLE. In study, we sought to understand the various camp cSLE...
Objective Many adolescent patients view their rheumatologist as primary physician, and therefore it is important to screen youth for sexual activity substance use recommended by the American Academy of Pediatrics. We implemented an electronic social history questionnaire (SHQ) alert system identify at‐risk behaviors in adolescents with rheumatic disease. Methods The SHQ was administered 14 years older a goal survey patients’ alcohol, tobacco, drug use. given via tablet at each rheumatology...
Abstract We present the use of whole‐genome sequencing to correctly diagnose progressive pseudorheumatoid dysplasia in patients with atypical clinical and radiologic findings prior diagnosis juvenile idiopathic arthritis.
Abstract Background The treatment of children with multisystem inflammatory syndrome in (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 receptor inhibitor, has also been used, but its effectiveness is not established yet. As optimal regimens for MIS-C remain unknown, we aimed assess the effect anakinra reducing hospital stay patients MIS-C. Methods We included admitted from May 2020 2021 diagnosed based on CDC...
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Abstract Background: The psychosocial burden of chronic disease can be substantial for adolescents with childhood-onset systemic lupus erythematosus (cSLE). Current literature is scarce on interventions that improve outcomes this population. Therapeutic recreation camps have been proposed as a beneficial experience chronically ill pediatric populations. However, their effective components not well characterized in patients cSLE. In study, we sought to understand the various camp cSLE from...