A5047799838- Immune Response and Inflammation
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Pain Management and Placebo Effect
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
Baylor University
2016-2018
Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which we now demonstrate be mitochondrial origin. further show healthy do not complete mitophagy upon induction damage. Rather, they extrude components, including DNA (mtDNA), devoid oxidized (Ox) residues. When mtDNA undergoes oxidation, it is...
Abstract Type I IFNs are crucial mediators of human innate and adaptive immunity massively produced from plasmacytoid dendritic cells (pDCs). IFN regulatory factor (IRF)7 is a critical regulator type production when pathogens detected by TLR 7/9 in pDC. However, hyperactivation pDC can cause life-threatening autoimmune diseases. To avoid the deleterious effects aberrant activation, tight regulation IRF7 required. Nonetheless, detailed mechanisms how transcription regulated still elusive. MYC...