A5010389791- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- COVID-19 Impact on Reproduction
- Infection Control in Healthcare
- Nosocomial Infections in ICU
- Kawasaki Disease and Coronary Complications
- Infection Control and Ventilation
- HIV, Drug Use, Sexual Risk
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- Adolescent Sexual and Reproductive Health
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Mechanical Circulatory Support Devices
- Rabies epidemiology and control
- Misinformation and Its Impacts
- Turtle Biology and Conservation
- Abdominal Surgery and Complications
- Adolescent and Pediatric Healthcare
- Cardiovascular and Diving-Related Complications
The University of Texas Southwestern Medical Center
2017-2025
Southwestern Medical Center
2017-2025
Medical City Children's Hospital
2020-2024
New York Proton Center
2024
Communities In Schools of Orange County
2024
University of Pittsburgh
2024
Lindsay Unified School District
2024
Oregon Medical Research Center
2024
Children's Medical Center
2022-2024
University of Miami
2014
Abstract Background Social media platforms like Twitter provide important insights into the public's perceptions of global outbreaks monkeypox. By analyzing tweets, we aimed to identify public knowledge and opinions on monkeypox virus related health issues. Methods We analyzed English-language tweets using keyword “monkeypox” from 1 May 23 July 2022. reported gender, ethnicity, race users predominant sentiment emotions. performed topic modeling compared cohorts who self-identify as LGBTQ+...
uch remains uncertain about the pathophysiology of various clinical presentations coronavirus disease 2019 (COVID-19).Severe infection with severe acute respiratory syndrome 2 (SARS-CoV-2) most often manifests a pulmonary that evolves from viral pneumonia to an inflammatory mediated distress syndrome.Two less common COVID-19 include multisystem in children (MIS-C) and cardiovascular (ACovCS) adults.These syndromes are being reported as distinct entities, but they have several overlapping...
Abstract Objective: Social media has become an important tool in monitoring infectious disease outbreaks such as coronavirus 2019 and highly pathogenic avian influenza (HPAI). Influenced by the recent announcement of a possible human death from H5N2 influenza, we analyzed tweets collected X (formerly Twitter) to describe messaging regarding HPAI outbreak, including mis- dis-information, concerns, health education. Methods: We involving keywords relating for 5 days (June 04 June 08, 2024)....
Abstract Background Clostridioides difficile testing by polymerase chain reaction (PCR) does not differentiate asymptomatic colonization from infection, and children are frequently colonized with toxigenic strains of C. difficile. Over-diagnosis infections can lead to adverse patient outcomes poorer quality metrics for hospitals.Figure 1:C. PCR orders following change in GI Panel, Interrupted Time Series Methods In January 2023 our pediatric health system enacted multimodal changes the...
We developed machine learning models to predict the presence of AMR organisms in blood cultures obtained at first patient encounter, offering a new and inspiring direction for antimicrobial resistance management. Three supervised classifiers were used: penalized logistic regression, random forest, XGBoost, which used classify five organisms: ESBL, CRE, AmpC, MRSA, VRE. The forest XGBoost performed best, with AUC-ROC values 0.70 92.9% negative predictive value, respectively. multi-class...
OBJECTIVES Throughout the pandemic, children with COVID-19 have experienced hospitalization, ICU admission, invasive respiratory support, and death. Using a multisite, national dataset, we investigate risk factors associated these outcomes in COVID-19. METHODS Our data source (Optum deidentified Electronic Health Record Dataset) included aged 0 to 18 years testing positive for between January 1, 2020, 20, 2022. ordinal logistic regression, identified an outcome scale: nonhospitalization, or...
The increased prevalence of antimicrobial resistant (AMR) infections is a significant global health threat, resulting in morbidity, mortality, and costs. drivers AMR are complex potentially impacted by socioeconomic factors. We investigated the relationships between geographic factors AMR.
Abstract Background Studies on COVID-19 in people with HIV (PWH) have had limitations. Further investigations risk factors and outcomes of SARS-CoV-2 infection among PWH are needed. Methods This retrospective cohort study leveraged the national OPTUM data set to investigate associated positivity for severe outcomes, including hospitalization, intensive care unit stays, death. A subset analysis was conducted examine HIV-specific variables. Multiple variable logistic regression used adjust...
Abstract In November 2022, our pediatric hospital replaced the requirement for universal masking of all healthcare personnel and visitors in clinical buildings with a only during patient encounters. Following this change, we observed an immediate, substantial, sustained increase healthcare-associated respiratory viral infections.
Abstract Analyzing data from a national deidentified electronic health record-based set using matched case–control study design, we found that antibiotic use and severity of illness were independent risk factors for healthcare-associated candidemia in adult patients hospitalized with SARS-CoV-2 infection. Interleukin-6 inhibitor corticosteroid not factors.
Intractable hemorrhage of the nasal or oropharyngeal cavities can be life threatening, and endovascular embolization is one few effective treatments for severe recurrent bleeds. Traditionally, embolic particles have been used transarterial embolization.To investigate safety efficacy a less commonly performed treatment-namely, feeding artery occlusion with liquid agents.We retrospectively reviewed our neurointerventional database patients who had undergone intractable Onyx, N-butyl-2...
The treatment of children with multisystem inflammatory syndrome in (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 receptor inhibitor, has also been used, but its effectiveness is not established yet. As optimal regimens for MIS-C remain unknown, we aimed assess the effect anakinra reducing hospital stay patients MIS-C.We included admitted from May 2020 2021 diagnosed based on CDC criteria. exposure interest...
Abstract Objective: To determine the difference in incidence of healthcare-associated respiratory viral infection (HARVI) a pediatric hospital depending on definition used. Design: Descriptive historical cohort study. Setting and participants: Patients aged 0–21 years old who were admitted between July 2013 June 2018 to 490-bed primary quaternary-care serving northern Texas. Methods: HARVI was defined using microbiologic confirmation, development new symptoms while hospitalized, exposure...
An adolescent with failure to thrive developed cuboid bone osteomyelitis and brain abscesses. Mold isolated from both locations was identified by universal genetic sequencing as Nannizziopsis spp, which is typically a pathogen of reptiles. The patient subsequently diagnosed STAT1 mutation successfully treated.
Background: Early diagnosis of HIV infection improves patient outcomes and reduces transmission. Adolescents make up one-fifth new diagnoses in the United States. We sought to quantify number missed opportunity encounters (MOEs) before for adolescents at a pediatric hospital (PediHosp) proximate adult which employs universal screening its emergency department (ED) (CountyHosp). Methods: An observational study 2 academic tertiary care hospitals States that included all 13–20 years old with...
Many hospitals caring for adult patients have discontinued the requirement contact precautions (CP) with methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization without reported negative effects. It is not clear whether this experience can be extrapolated to pediatric facilities.
Abstract Background: The interplay between SARS-CoV-2 and contemporaneous bacterial or fungal culture growth may have crucial implications for clinical outcomes of hospitalized patients. This study aimed to quantify the effect microbiological positivity on mortality among patients with SARS-CoV-2. Methods: In this retrospective cohort study, we included adult from OPTUM COVID-19 specific data set, who tested positive within 14 days hospitalization 01/20/2020 01/20/2022. We examined...
Abstract Objective: Describe and compare the prevalence of symptomatic asymptomatic or recently resolved respiratory infections in hospitalized children. Design: Cross-sectional study. Setting: Three hospital primary-to-quaternary care pediatric healthcare system. Patients: People less than 22 years old who underwent admission screening for viruses using a multitarget polymerase chain reaction (PCR) panel from August 2020 through April 2022. Methods: The symptom status each patient was...
Background: In the management of children with sepsis, inflammatory markers are often obtained upon admission and repeated frequently. It is unclear if serial monitoring procalcitonin useful for predicting patient outcomes. The focus our study to identify trend levels was predictive clinical outcomes in sepsis. Methods: We performed a retrospective diagnostic evaluate association between change Encounters 1 8 years old sepsis ICD 10 diagnosis code meeting criteria from May 2020 2022 at one...
Abstract Background Viral respiratory infections (VRIs) are common and occupational risks for healthcare personnel (HCP). VRIs can also be acquired at home other settings among HCPs. We sought to determine if preschool-aged household contacts a risk factor HCPs working in outpatient settings. Methods conducted secondary analysis of data from cluster randomized trial 7 medical centers the United States over 4 influenza seasons 2011–2012 2014–2015. Adult who routinely came within 6 feet...
Abstract Nonpharmaceutical interventions (NPIs) have “flattened the curve” of coronavirus disease 2019 pandemic; however effect these on other respiratory viruses is unknown. We used aggregate level case count data for 8 and compared institutional statewide counts before during period that NPIs were active. observed a 61% decrease (incidence rate ratio, 0.39; 95% confidence interval, .37–.41; P < .001) in non–severe acute syndrome 2 viral infections when implemented. This finding, if...