A5039986273- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Trauma and Emergency Care Studies
- Drug-Induced Hepatotoxicity and Protection
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Protease and Inhibitor Mechanisms
- Cardiac Health and Mental Health
- Health disparities and outcomes
- Meta-analysis and systematic reviews
- Venous Thromboembolism Diagnosis and Management
- Cancer Treatment and Pharmacology
- Obstructive Sleep Apnea Research
- Legionella and Acanthamoeba research
- Rheumatoid Arthritis Research and Therapies
- Global Maternal and Child Health
- Glioma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Diagnosis and Treatment of Venous Diseases
- COVID-19 Clinical Research Studies
- HER2/EGFR in Cancer Research
The University of Texas Southwestern Medical Center
2022-2024
Southwestern Medical Center
2022-2024
Royal College of Emergency Medicine
2023
Royal London Hospital
2013-2023
Vanderbilt University
2023
The University of Texas Health Science Center at Houston
2023
Vanderbilt University Medical Center
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
Post Graduate Institute of Medical Education and Research
2022
The University of Texas at El Paso
2022
Insertion of a ventriculoperitoneal shunt for hydrocephalus is one the commonest neurosurgical procedures worldwide. Infection implanted affects up to 15% these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition quality life. Our aim was determine clinical cost-effectiveness antibiotic (rifampicin clindamycin) or silver shunts compared with standard at reducing infection.In this parallel, multicentre, single-blind, randomised controlled trial, we...
There is a paucity of health policy relevant data for chronic liver disease from India, impeding formulation an interventional strategy to address the issue. A prospective, multicentric study delineate etiology and clinical profile in India reported here. centrally coordinated monitored web-based repository was developed (Feb, 2010 Jan, 2013) analyzed. Eleven hospitals different parts participated. Data were uploaded into web based proforma by single centre according standardized protocol....
BackgroundGastro-oesophageal reflux disease is a common chronic ailment that causes uncomfortable symptoms and increases the risk of oesophageal adenocarcinoma. We aimed to report burden gastro-oesophageal in 195 countries territories between 1990 2017, using data from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2017.MethodsWe did systematic review identify measurements prevalence geographically defined populations worldwide 2017. These estimates were analysed with DisMod-MR,...
Background Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular risks. This study aimed to assess the prevalence of probable OSA and its relationship risks diseases focusing on age‐stratified young adults (20–40 years) older (>40 years). Methods Results The used cross‐sectional design, analyzing data from National Health Nutrition Examination Survey conducted between 2013 2018, comprising 9887 community‐dwelling aged ≥20 years. Probable was determined basis...
Abstract Background and Aim: Acute on chronic liver failure (ACLF) because of precipitating factors (variceal bleed/infections) identifies cirrhotics at risk for high short‐term mortality. Information ACLF acute hepatic insults is lacking. The aim the study was to evaluate in their effect course outcome. Methods: In a prospective study, 213 consecutive patients were included. Etiology insult, frequency silent, overt disease (CLD), organ (OF), outcomes assessed. Prognostic models such as...
Objective Early risk assessment is important in acute pancreatitis (AP). The primary objective of this study was to compare various scores and biochemical markers done on the day admission predicting outcome. Methods Demographic, clinical, laboratory data patients presenting within 2 weeks onset were collected. Various calculated measured admission. Optimum cutoffs identified through receiver operating curve analysis. Multivariate analysis used identify predictors Results Of 343 included,...
Results of endovascular interventions in hepatic venous outflow tract obstruction (HVOTO) have been reported from limited studies. Treatment outcomes and prognostic scores need further validation.To evaluate treatment for an Indian population.Consecutive patients with diagnosed at a tertiary centre were included. Technical success clinical response after interventional therapy documented. Predictors survival assessed Cox-proportional model. A new score was derived the factors significant on...
Acute-on-chronic liver failure (ACLF) may be precipitated by various hepatic insults. The present study evaluated the outcomes of ACLF with different acute insults.A total 368 patients were included. Data collected included etiologies insult and underlying chronic disease, organ failure. Model for end-stage disease (MELD), consortium (CLIF)-C ACLF, physiology health evaluation (APACHE) II scores calculated. Predictors survival assessed Cox proportional hazard model.The most frequent was...
The increasing utilisation of decompressive craniectomy for traumatic brain injury and stroke has led to an increase in the number cranioplasties undertaken. Cranioplasty is also undertaken following excision tumours originating from or invading skull vault, removal bone flaps due post-operative infection, management rarer causes oedema and/or refractory intracranial hypertension. existing literature which mainly consists single-centre, retrospective studies, shows a significant variation...
Intestinal permeability (IP) has been shown to be increased in acute pancreatitis (AP) and is considered responsible for development of septic complications. However, the mechanism increase IP not well studied. We studied whether alteration tight junction proteins (TJP) any role altered patients with AP.This a prospective study conducted at tertiary care referral center. Twenty consecutive moderate severe AP fulfilling criteria were included along 20 controls that underwent...
OBJECTIVES Throughout the pandemic, children with COVID-19 have experienced hospitalization, ICU admission, invasive respiratory support, and death. Using a multisite, national dataset, we investigate risk factors associated these outcomes in COVID-19. METHODS Our data source (Optum deidentified Electronic Health Record Dataset) included aged 0 to 18 years testing positive for between January 1, 2020, 20, 2022. ordinal logistic regression, identified an outcome scale: nonhospitalization, or...
This study explores the relationship between depression and cardiovascular disease (CVD) in US adult population, focusing on sex differences.
The authors assess the utility of routine biopsy at vertebroplasty for vertebral compression fracture (VCF) as a tool in early detection malignancy presumed benign VCF.A prospective observational study was conducted on cohort consecutive patients undergoing over 5-year period between April 2006 and March 2011 Royal London Hospital. Polymethylmethacrylate cement injection used every procedure. Intraoperative body performed routinely level VCF. Pain visual analog scale (VAS) scores, Oswestry...
Acute-on-chronic liver failure (ACLF) is associated with a high short-term mortality rate in the absence of transplantation. The role therapeutic plasma exchange (TPE) improving outcomes ACLF and acute decompensation (AD) unclear. In this retrospective analysis, we aimed to determine impact TPE on patients ACLF.ACLF receiving standard medical treatment (SMT) were propensity score matched (PSM) those SMT alone (1:1) for sex, grades ACLF, CLIF C scores, presence hepatic encephalopathy. primary...
Genetic variation in DNA repair genes can modulate capacity and may be related to the risk of cancer. The human papillomavirus is considered a necessary but not sufficient cause for cervical cancer and, therefore, other factors contribute carcinogenesis. A hereditary component this neoplasia has been reported. Evaluation association six polymorphisms was carried out following genes: XRCC1 (Arg194Trp, Arg280His, Arg399Gln), ERCC1 (Asp118Asp), ERCC2 (Lys751Gln), ERCC4 (Arg415Gln). cases...