Kristian Aquilina
A5073950565- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Surgical Oncology
- Neuroblastoma Research and Treatments
- Law, logistics, and international trade
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Conflict of Laws and Jurisdiction
- International Law and Human Rights
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Sarcoma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Chromatin Remodeling and Cancer
- Growth Hormone and Insulin-like Growth Factors
Great Ormond Street Hospital for Children NHS Foundation Trust
2016-2025
Great Ormond Street Hospital
2016-2025
University College London
2016-2025
University of Malta
2010-2024
Victor (Japan)
2024
Tokyo Women's Medical University
2024
University of Birmingham
2024
University Health Network
2024
Toronto Western Hospital
2024
University of Toronto
2024
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
Hypoxic/ischemic (HI) brain injury affects 1 to 6 per 1000 live human births, with a mortality of 15% 20%. A quarter survivors have permanent disabilities. Hypothermia is the only intervention that improves outcome; however, further improvements might be obtained by combining hypothermia additional treatments. Xenon noble anesthetic gas an excellent safety profile, showing great promise in vitro and vivo as neuroprotectant. We investigated combinations 50% xenon (Xe(50%)) 32 degrees C (HT(32...
To investigate whether inhaling 50% xenon during hypothermia (HT) offers better neuroprotection than or HT alone.Ninety-eight newborn pigs underwent a 45-minute global hypoxic-ischemic insult severe enough to cause permanent brain injury, and 12 sham protocol. Pigs then received intravenous anesthesia were randomized 6 treatment groups: (1) normothermia (NT; rectal temperature 38.5 degrees C, n = 18); (2) 18 hours with NT (n 12); (3) (rectal 33.5 (4) 24 17); (5) (6) 17). Fifty percent was...
Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They histologically complex, showing cystic and solid components, latter comprised different morphological cell types (e.g. β-catenin-accumulating cluster cells palisading epithelium), surrounded by a florid glial reaction with immune cells. Here, we carried out RNA sequencing on 18 ACP samples integrated these data an existing transcriptomic dataset. No...
Insertion of a ventriculoperitoneal shunt for hydrocephalus is one the commonest neurosurgical procedures worldwide. Infection implanted affects up to 15% these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition quality life. Our aim was determine clinical cost-effectiveness antibiotic (rifampicin clindamycin) or silver shunts compared with standard at reducing infection.In this parallel, multicentre, single-blind, randomised controlled trial, we...
Fifty percent of pediatric low-grade gliomas affect the optic pathway, hypothalamus, and suprasellar areas (OP/HSGs), resulting in significant long-term neuroendocrinopathy.This study aimed to dissect tumor- from treatment-related risk factors for OP/HSG-associated was a retrospective case notes analysis 166 children with newly diagnosed OP/HSGs at our quaternary center between 1980 2010 by multivariate Cox, linear, logistic regression.Patients were median (range) age 4.9 (0.2-15.4) years...
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection patient groups suitable targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant molecular subgroups. Materials Methods In this retrospective study, consecutive patients with newly diagnosed at MRI 12 international sites between July 1997 May 2020...
BackgroundSelective dorsal rhizotomy (SDR) is an irreversible surgical procedure involving the division of selected sensory nerve roots, followed by intensive physiotherapy. The aim to improve function and quality life in children with cerebral palsy a Gross Motor Function Classification System (GMFCS) level II or III (walks without assistive devices, respectively). We assessed gross motor before after SDR postoperative study commissioned NHS England.MethodsWe did prospective observational...
Background Progressive ventricular dilatation after intraventricular haemorrhage (IVH) in preterm infants has a very high risk of severe disability and death. Drainage, irrigation fibrinolytic therapy (DRIFT), randomised controlled trial (RCT), reduced cognitive impairment at 2 years. Objective To assess if the advantage DRIFT seen years persisted until school age. Participants The RCT conducted four centres recruited 77 with IVH progressive enlargement over specified measurements. Follow-up...
Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as single entity when assessing CMS risk; however, recent studies highlighting their clinical heterogeneity suggest the need subgroup-specific analysis. Here, we examine large international multicenter cohort molecularly characterized medulloblastoma patients to assess predictors...
The goal of this study was to characterize the complications and morbidity related surgical management pediatric fourth ventricle tumors.
Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors. Presently, MRI is the mainstay of disease diagnosis and surveillance. We identify clinically significant computational features from create a prognostic machine learning model.We isolated tumor volumes T1-post-contrast (T1) T2-weighted (T2) MRIs 177 treatment-naïve DIPG patients an international cohort for model training testing. The Quantitative Image Feature Pipeline PyRadiomics was used feature extraction....
Introduction Given its proximity to the central nervous system, surgical site infections (SSIs) after craniotomy (SSI-CRAN) represent a serious adverse event. SSI-CRAN are associated with substantial patient morbidity and mortality. Despite recognition of SSI in other fields, there is paucity evidence neurosurgical literature devoted skin closure, specifically patients brain tumors. The primary objective this service evaluation ascertain incidence risk factors SSI-CRAN. secondary objectives...
Abstract Cancer predisposition syndromes mediated by recessive cancer genes generate tumors via somatic variants (second hits) in the unaffected allele. Second hits may or not be sufficient for neoplastic transformation. Here we performed whole-genome and whole-exome sequencing on 479 tissue biopsies from a child with neurofibromatosis type 1, multisystem cancer-predisposing syndrome constitutive monoallelic NF1 inactivation. We identified multiple independent driver histologically normal...
Abstract Background Paediatric brain tumour survivors can have neurocognitive deficits that negatively impact their quality of life, but it is unclear if are primarily caused by treatments, such as radiotherapy, or manifest earlier due to the and related complications. The aim this work characterise white matter injury tumours, unrelated treatment effects, explore heterogeneity in these abnormalities between individual patients. Methods We used diffusion tensor imaging (DTI) Neurite...