A5004808635- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Hedgehog Signaling Pathway Studies
- Acute Lymphoblastic Leukemia research
- Testicular diseases and treatments
- Genetic factors in colorectal cancer
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Advances in Oncology and Radiotherapy
- RNA modifications and cancer
- Cerebrospinal fluid and hydrocephalus
- Tumors and Oncological Cases
- Adrenal and Paraganglionic Tumors
- Influenza Virus Research Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
King Hussein Cancer Center
2016-2025
Tenri Hospital
2021
University of Jordan
2021
Hospital Universitario Virgen del Rocío
2021
SickKids Foundation
2021
Hospital Sant Joan de Déu Barcelona
2021
Hospital Infantil Universitario Niño Jesús
2021
Instituto Nacional de Pediatria
2021
Hospital for Sick Children
2019
University of Toronto
2017
Biallelic mismatch repair deficiency (bMMRD) is a cancer predisposition syndrome affecting primarily individuals from consanguinous families resulting in multiple childhood cancers including high grade gliomas (HGG). This the first study to assess prevalence of bMMRD among patients with HGG countries where consanguinity high. We collected molecular and clinical information on all children diagnosed supratentorial primitive neuroectodermal tumors (sPNET) between 2003 2013 at King Hussein...
Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as single entity when assessing CMS risk; however, recent studies highlighting their clinical heterogeneity suggest the need subgroup-specific analysis. Here, we examine large international multicenter cohort molecularly characterized medulloblastoma patients to assess predictors...
Primary central nervous system (CNS) tumors are often associated with relatively poor outcomes. Data on the epidemiology and outcome of CNS in Jordan scarce. We aim to report primary patients managed at a comprehensive cancer care center Jordan. performed retrospective chart review all Jordanian tumor diagnosis who were between July 2003 June 2019. included entities described 2021 WHO classification system, addition pituitary neuroendocrine (PitNETs). used Kaplan-Meier method estimate...
Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood (iMB) has no standard care at relapse. This work aimed to evaluate post-relapse survival (PRS) explore prognostic factors patients with nodular desmoplastic (ND) and/or SHH iMB. international retrospective study included 147 subjects diagnosed relapsed Nodular Desmoplastic/SHH iMB between 1995 2017, < 6 years old original diagnosis, treated without initial craniospinal irradiation (CSI)....
Abstract Effective treatment of children with low grade glioma (LGG) requires a functioning multi‐disciplinary team adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities personnel. In addition, the treating centre should have capacity to manage variety LGG treatment‐associated complications. These requirements made it difficult for many centers in middle‐income countries (LMIC) offer effective follow up. This article provides management...
The management of central nervous system tumors is challenging in low- and middle-income countries. Little known about applicability twinning initiatives with high-income countries neuro-oncology. In 2004, a monthly neuro-oncology video-teleconference program was started between King Hussein Cancer Center (Amman, Jordan) the Hospital for Sick Children (Toronto, Ontario, Canada). More than 100 conferences were held > 400 cases discussed. aim this work to assess sustainability such an...
HSCT can be curative for many PID. Little is known about the outcome of patients with PID in developing countries. We retrospectively reviewed all children who received at KHCC Jordan between August 2003 and October 2011. Twenty-eight were identified. The median age was 16 months (3 months-17 yr). Patients' diagnoses SCID (n = 16), CHS 3), HLH WAS 2), Griscelli syndrome 1), ALPS Omenn's DiGeorge 1). Seventeen HLA-matched related HSCT, eight maternal un-manipulated haploidentical three...
Pleomorphic xanthoastrocytoma is a rare brain tumor with unique high frequency of BRAF V600E mutation which plausible for targeted therapy. The anaplastic variant has generally worse prognosis. We present an adolescent patient disseminated relapse pleomorphic following surgery, radiotherapy, and chemotherapy. She had dramatic prolonged response to inhibitor (Dabrafinib) later addition MEK (Trametinib) on progression. With minimal side effects good quality life, the alive more than 2 years...
PURPOSE Medulloblastoma is composed of four clinically and prognostically distinct molecular subgroups (WNT, SHH, group 3, 4). However, the clinical implications these in context unique challenges low- to middle-income countries are rarely reported. METHODS We assembled an institutional cohort children (3-18 years) diagnosed with medulloblastoma treated Jordan between 2003 2016. Tumors were subgrouped by NanoString correlated radiologic characteristics. RESULTS Eighty-eight patients...
Abstract Pediatric craniopharyngioma is a rare tumor with excellent survival but significant long‐term morbidities due to the loco‐regional growth or secondary its treatment. Visual impairment, panhypopituitarism, hypothalamic damage, and behavioral changes are among main challenges. This should be managed under care of multidisciplinary team determine optimum treatment within available resources. particularly important for low middle‐income countries where resources variable. report...
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare of the CNS mostly seen in infants and often associated with dismal outcome. Despite heterogeneous morphology and/or immunoprofile, its diagnosis nowadays relies on negative INI-1/BAF47 nuclear immunostain cells. We aim to investigate number immunohistochemical antibodies as potential diagnostic prognostic markers. All AT/RT cases patients younger than 18 years age were included. Demographics, clinical features outcome collected. Immunostains...
Introduction Advances in molecular diagnostics led to improved targeted interventions the treatment of pediatric CNS tumors. However, capacity test for these is limited LMICs, and thus their value needs exploration. Methods We reviewed our experience with NGS testing (TruSight RNA Pan-Cancer-seq panel) tumors at KHCC/Jordan (March/2022–April/2023). Paraffin blocks’ scrolls were shipped SickKids laboratory based on multidisciplinary clinic (MDC) recommendations. patients’ characteristics,...
Introduction Most pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use low-middle-income-countries (LMICs) are limited. Methods We retrospectively reviewed our Jordanian experience of compassionate inhibitors treating children with gliomas. patients’ clinical characteristics, response, side effects. Results Twenty patients (13 males,...
Abstract Background Limited data are available on disease characteristics and outcome of children with cancer who contracted the H1N1 influenza infection during 2009 pandemic. Methods All 76 pediatric patients documented presented to Pediatric Department at King Hussein Cancer Center (KHCC) between October 1 December 1, were reviewed for clinical course disease. Results Two‐thirds had hematological malignancies half receiving non‐intensive chemotherapy time infection. With exception two...
Results of high-dose chemotherapy (HDCT) protocols for the management malignant central nervous system (CNS) tumors in infants are mostly reported high-income countries. We evaluated feasibility and results such a middle-income country (Jordan).A retrospective study infants' charts with CNS between 2006 2015 who were treated according to HeadStart (HS) protocols. Data included patients' demographics, complications, cost.We identified 18 patients median age 29 months (range, 9-62 months) at...
Pediatric intracranial germ cell tumors (iGCT) are rare, with limited data available from Arabic countries.We retrospectively reviewed the medical charts of children <18 years diagnosed iGCT at King Hussein Cancer Center/Jordan (January 2003 to December 2020) for clinical characteristics, treatment, and morbidities.Sixteen patients had germinoma; median age was 6.9 symptoms duration 8 months. Nine were suprasellar, five pineal, two bifocal. Four metastatic. Eight slightly elevated beta...