A5051988707- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Acute Lymphoblastic Leukemia research
- Advances in Oncology and Radiotherapy
- Renal cell carcinoma treatment
- Neutropenia and Cancer Infections
- Ethics and Legal Issues in Pediatric Healthcare
- Ocular Oncology and Treatments
- Global Health and Surgery
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Emergency and Acute Care Studies
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Antimicrobial Resistance in Staphylococcus
- Polyomavirus and related diseases
- Child and Adolescent Health
- Blood disorders and treatments
- Healthcare Policy and Management
Red Cross War Memorial Children's Hospital
2015-2024
University of Cape Town
2015-2024
ORCID
2024
University of Alberta
2015-2017
National Health Laboratory Service
2013-2016
Groote Schuur Hospital
2016
Center for Drug Evaluation and Research
2014
United States Food and Drug Administration
2014
Chris Hani Baragwanath Hospital
2014
Walter Sisulu University
2014
Abstract Background Pediatric-type diffuse low-grade gliomas (pLGG) harboring recurrent genetic alterations involving MYB or MYBL1 are closely related tumors. Detailed treatment and outcome data of large cohorts still limited. This study aimed to comprehensively evaluate pLGG with these define optimal therapeutic strategies. Methods We retrospectively reviewed details from patients treated referred for pathologic review at St. Jude Children’s Research Hospital. Tumor specimens were centrally...
Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 families, through exome and Sanger sequencing. By contrast, no similar are present 1,000 population controls (P<0.0001). Each mutation segregates with the family second mutational event available tumours. key component polymerase-associated factor 1 complex which has multiple roles RNA polymerase II regulation implicated embryonic organogenesis maintenance stem cell pluripotency. These data...
Abstract Many children with cancer in low‐ and middle‐income countries are treated hospitals lacking key infrastructure, including diagnostic capabilities, imaging modalities, treatment components, supportive care, personnel. Childhood regimens adapted to local conditions provide an opportunity cure as many possible the available resources, while working improve services care. This paper from Adapted Treatment Regimens Working Group of Pediatric Oncology Developing Countries committee...
Effective treatment of children with medulloblastoma requires a functioning multi-disciplinary team adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities personnel. In addition the treating centre should have capacity to effectively screen manage any tumour treatment-associated complications. These requirements made it difficult for many low middle-income countries (LMIC) centres offer curative treatment. This article provides management...
Introduction Pediatric low-grade glioma (LGG) is a World Health Organization (WHO) Global Initiative for Childhood Cancer (GICC) index tumor constituting up to third of pediatric central nervous system (CNS) tumors. The baseline characteristics, survival, and management resources LGG in Africa are unknown. We aimed evaluate the neuro-oncology multidisciplinary team resources, epidemiology, survival outcomes document information prior GICC implementation. Methods study consisted two parts:...
In 2008 the South African Children's Cancer Study Group decided to review epidemiology, management, and chemotherapy response of HIV-positive children with malignancy.This is a retrospective analysis data collected from records diagnosed malignancy at 7 university-based pediatric oncology units serving 8 9 provinces in Africa.Two hundred eighty-eight were 289 malignancies between 1995 2009. Age diagnosis ranged 17 days 18.64 years; median 5.79 years. Of 220 HIV-associated malignancies, there...
Background: Little is known on the risk of cancer in HIV-positive children sub-Saharan Africa. We examined incidence and factors AIDS-defining other cancers pediatric antiretroviral therapy (ART) programs South Methods: linked records 5 ART Johannesburg Cape Town to those oncology units, based name surname, date birth, folder civil identification numbers. calculated rates obtained hazard ratios (HR) with 95% confidence intervals (CI) from Cox regression models including ART, sex, age degree...
In low- and middle-income countries (LMICs), limited resources, suboptimal risk stratification, disproportionate patient-to-infrastructure ratio result in low survival of patients with acute myeloid leukemia (AML). A high incidence relapse, inherent to the biology, renders management arduous. The challenge treating AML LMICs is balancing intensity myelosuppressive chemotherapy, which appears necessary for cure, available supportive care, influences treatment-related mortality....
Abstract Kaposi sarcoma (KS) is common where HIV infection endemic. Antiretroviral therapy (ART) has reduced the incidence in well‐resourced settings but some parts of world access to ART delayed. These recommendations are for use only minimal requirements treatment available. Consensus was sought management childhood HIV‐associated KS this setting. There no randomised controlled studies chemotherapy children and these have drawn on consensus a group experts published reports from adults....
Background. Childhood cancer is an emerging problem in Africa. Its extent hazy because data are scarce, but it should be addressed. This the first report from South African Children's Tumour Registry (SACTR), which covers whole of Africa (SA). It provides minimal estimates incidence and discusses challenges surveillance control a child population middle-income country. Only about 2% covered by registries producing comparable data. Objective. To present interpret patterns trends childhood...
Abstract Effective treatment of children with low grade glioma (LGG) requires a functioning multi‐disciplinary team adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities personnel. In addition, the treating centre should have capacity to manage variety LGG treatment‐associated complications. These requirements made it difficult for many centers in middle‐income countries (LMIC) offer effective follow up. This article provides management...
Abstract Pediatric radiotherapy is a critical part of pediatric oncology protocols and the quality may determine future life for long‐term survivors. Multidisciplinary team decision making provides basis high‐quality care. However, delivery dependent on resources. This article guidelines good radiation therapy in resource‐limited countries based rational procurement maintenance planning, protocol development, three‐dimensional assurance, adequate staff numbers training.