A5043352783- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Advances in Oncology and Radiotherapy
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Global Health and Surgery
- Global Cancer Incidence and Screening
- Bacterial Identification and Susceptibility Testing
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Family Support in Illness
- COVID-19 and healthcare impacts
- Ethics and Legal Issues in Pediatric Healthcare
- Palliative Care and End-of-Life Issues
- Pharmaceutical Economics and Policy
- Renal and related cancers
- Pharmaceutical studies and practices
- Hematological disorders and diagnostics
- Adolescent and Pediatric Healthcare
- Ethics in Clinical Research
- Neutropenia and Cancer Infections
- Family and Patient Care in Intensive Care Units
- Economic and Financial Impacts of Cancer
- Interprofessional Education and Collaboration
Uganda Cancer Institute
2014-2024
Lagos University Teaching Hospital
2024
Makerere University
2019-2023
Red Cross War Memorial Children's Hospital
2019
University of Cape Town
2019
The prevalence and factors associated with major depressive disorder (MDD) among adults cancer have been documented in the scientific literature. However, this data is limited children adolescents cancer; especially low resource settings such as Uganda. We assessed MDD attending Uganda institute out-patient clinic.This was a cross-sectional study which three hundred fifty-two any diagnosis were screened for depression using Child Depression Inventory (CDI) evaluated mini neuropsychiatric...
The aim of this study was to determine the predominant bacterial species causing bacteremia among febrile cancer patients, and their antibacterial resistance profiles at Uganda Cancer Institute. We enrolled in-patients with a documented fever (≥ 37.5 °C). Bacteria from positive blood cultures were identified using standard methods biochemically. Antibacterial susceptibility testing performed Kirby–Bauer disc diffusion method. From total 170 episodes, obtained 24 (14.1%). A culture more...
Introduction Pediatric low-grade glioma (LGG) is a World Health Organization (WHO) Global Initiative for Childhood Cancer (GICC) index tumor constituting up to third of pediatric central nervous system (CNS) tumors. The baseline characteristics, survival, and management resources LGG in Africa are unknown. We aimed evaluate the neuro-oncology multidisciplinary team resources, epidemiology, survival outcomes document information prior GICC implementation. Methods study consisted two parts:...
PURPOSE Patients with diffuse large B-cell lymphoma (DLBCL) who are treated in low-resource settings have inferior outcomes compared those high-resource settings. Rituximab, an anti-CD20 monoclonal antibody, when combined chemotherapy, improves overall survival (OS) for DLBCL. However, part due to the limited availability of infusion centers countries, rituximab is rarely used. Subcutaneous (sqR) a potential solution; however, its safety and efficacy not been tested low-income countries....
ABSTRACT A long pre‐diagnostic interval is reported to be a significant challenge in childhood cancer, particularly low‐ and middle‐income countries (LMICs) where advanced‐stage disease at diagnosis results poor survival. The International Society of Paediatric Oncology the Pediatric Association launched “Childhood Cancer Early Diagnosis Appropriate Referral (CEDAR)” project 2022 as educational webinars on six index cancers World Health Organization Global Initiative for Childhood improve...
Abstract Kaposi sarcoma (KS) is common where HIV infection endemic. Antiretroviral therapy (ART) has reduced the incidence in well‐resourced settings but some parts of world access to ART delayed. These recommendations are for use only minimal requirements treatment available. Consensus was sought management childhood HIV‐associated KS this setting. There no randomised controlled studies chemotherapy children and these have drawn on consensus a group experts published reports from adults....
Abstract Purpose “Endemic” Burkitt lymphoma (BL) is a common childhood cancer in Africa. Social and treatment factors may contribute to poor survival. With the aim of improving BL outcomes Uganda, we undertook comprehensive project (BL Project) that provided diagnostic support, access standard chemotherapy, nutritional evaluations, case management. We evaluated survival children with context project. Patients methods followed by Project who consented research were enrolled this study....
Background Perceptions of high cost and resource intensity remain political barriers to the prioritization childhood cancer treatment programs in many low‐ middle‐income countries (LMICs). Little knowledge exists actual cost‐effectiveness such programs. To improve outcomes for children with Burkitt lymphoma (BL), most common Africa, Uganda Cancer Institute implemented a comprehensive BL program 2012. We undertook an economic evaluation ascertain therapy specific LIC setting. Methods compared...
Abstract Background Nearly 90% children with cancer reside in low‐ and middle‐income countries, which face multiple challenges delivering high‐quality pediatric onco‐critical care (POCC). We recently identified POCC quality capacity indicators for PROACTIVE (PediatRic Oncology cApaCity assessment Tool IntensiVe carE), a tool that evaluates strengths limitations services. This study describes pilot testing of PROACTIVE, development center‐specific reports, identification common challenges....
The authors introduce a functional communication framework that can be used for global pediatric cancer research.
In the face of unprecedented challenges because coronavirus disease 2019, interdisciplinary pediatric oncology teams have developed strategies to continue providing high-quality cancer care. This study explored factors contributing health care resilience as perceived by childhood providers in all resource level settings. qualitative consisted 19 focus groups conducted 16 countries 8 languages. Seven been previously defined important for resilient including: 1) situ practical experience, 2)...
Brain tumors are the most common solid in children and a leading cause of cancer-related mortality worldwide. Data on epidemiology management pediatric brain Uganda limited. We aimed to assess clinicopathological profile at national oncology center since inception weekly multidisciplinary meetings. Records younger than19 years diagnosed with primary Cancer Institute between 2017 2021 were retrospectively reviewed. Patient tumor characteristics collected team treatment plans for analysis....
The survival rates for children and adolescents with osteosarcoma in low-income countries are poor. Insufficient data regarding the challenges of managing resource-limited settings has been published. We evaluated treatment aim improving health system management outcomes.
Background and objectivesAlthough 80% of pediatric cancer cases occur in low-and middle-income countries, specialists the field hematology oncology (PHO) are scarce, which is a major reason for dismal survival rates children with blood disorders sub-Saharan Africa (SSA) compared that high-income countries (HICs).Traditional models specialty training SSA physicians (eg, those residency or fellowship HICs) inevitably result brain drain from SSA.Moreover, content context HICs often irrelevant...
Abstract Background/purpose Stage at diagnosis is an important metric in treatment and prognosis of cancer, also planning evaluation cancer control. In sub‐Saharan Africa (SSA), for the latter, only data source population‐based registry (PBCR). For childhood cancers, 'Toronto Staging Guidelines' have been developed to facilitate abstraction stage by personnel. Although feasibility staging using this system has shown, there limited information on accuracy staging. Methods A panel case records...
Abstract Objectives High levels of caregiver burden (CB) are experienced by informal caregivers pediatric patients with cancer. There is increasing evidence highlighting the extent CB across sub-Saharan African countries, although there remains lack interventions that target improvements in their experience. This study aimed to determine impact a structured psychoeducation program on caregivers’ outcomes relating preparedness provide care, caregiving, and quality life (QoL). Methods...
Abstract We examined trends in childhood cancer incidence sub‐Saharan Africa using data from two population‐based registries Harare (Zimbabwe) and Kyadondo (Uganda) with cases classified according to the International Classification of Childhood Cancer explored reasons for observed variations changes. Over whole 25‐year period (1991‐2015) studied, there were only small, nonsignificant overall incidence. Nevertheless, within period, peaks occurred 1996 2001 2003 2006 (Uganda). Kaposi sarcoma...