A5047977487- Intestinal Malrotation and Obstruction Disorders
- Clinical Nutrition and Gastroenterology
- Electrospun Nanofibers in Biomedical Applications
- Gastrointestinal disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Appendicitis Diagnosis and Management
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Diverticular Disease and Complications
- Congenital Diaphragmatic Hernia Studies
- Global Health and Surgery
- Hernia repair and management
- Esophageal and GI Pathology
- Child Nutrition and Feeding Issues
- Tracheal and airway disorders
- Congenital gastrointestinal and neural anomalies
- Trauma Management and Diagnosis
- Abdominal Trauma and Injuries
- Airway Management and Intubation Techniques
- Voice and Speech Disorders
- Cardiac and Coronary Surgery Techniques
- Global Health Workforce Issues
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Drug Transport and Resistance Mechanisms
Saint Louis University
2016-2022
Cardinal Glennon Children’s Medical Center
2015-2022
Yale University
2009-2022
Texas Children's Hospital
2022
Baylor College of Medicine
2022
St. Louis Children's Hospital
2022
Riley Hospital for Children
2022
Indiana University Health
2022
Indiana University – Purdue University Indianapolis
2022
Children's Mercy Hospital
2022
We developed a tissue-engineered vascular graft composed of biodegradable scaffold seeded with autologous bone marrow-derived mononuclear cells (BMMCs) that is currently in clinical trial and analogous mouse models to study mechanisms neovessel formation. previously reported human BMMCs were rapidly lost after implantation into immunodeficient mice as host macrophages invaded the graft. As consequence, resulting was entirely cell origin. Here, we investigate source neotissue syngeneic...
A major limitation of tissue engineering research is the lack noninvasive monitoring techniques for observations dynamic changes in single tissue-engineered constructs. We use cellular magnetic resonance imaging (MRI) to track fate cells seeded onto functional vascular grafts (TEVGs) through serial imaging. After vitro optimization, murine macrophages were labeled with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and scaffolds that surgically implanted as inferior vena cava...
The manual seeding of cells onto a biodegradable scaffold by pipetting is an effective method cell seeding. However, the widespread use and ultimate clinical utility this technique limited operator variability. This study was conducted to evaluate operator-independent vacuum-seeding for in upcoming trial. Using bone marrow-derived mononuclear cells, we achieved comparable manually seeded scaffolds terms cellular attachment, distribution, viability vacuum-seeded grafts at vacuum pressures -25...
Background: Total parenteral nutrition (TPN) provides all nutritional needs intravenously. Although lifesaving, enthusiasm is significantly tempered due to side effects of liver and gut injury, as well lack mechanistic understanding into drivers TPN injury. We hypothesized that the state luminal deprivation with drives alterations in gut–systemic signaling, contributing tested this hypothesis using our ambulatory model. Methods: A total 16 one-week-old piglets were allocated randomly (n = 8)...
To describe a modification in the Georgeson technique for laparoscopic gastrostomy tube (LGT) placement and compare rate of reoperation disruption tract after LGT by our modified to own series percutaneous endoscopic (PEG) tubes as well published rates LGTs PEGs.In 2003, we include laparoscopically placed sutures secure stomach abdominal wall. A retrospective review was performed on all children undergoing PEGs from March 2003 October 2009. In addition, literature identify complications...
Abstract Background Parenteral nutrition (PN) provides intravenously; however, this life‐saving therapy is associated with significant liver disease. Recent evidence indicates improvement in PN‐associated injury animals intact gut treated enteral bile acid (BA), chenodeoxycholic (CDCA), and a farnesoid X receptor (FXR) agonist, which drives the gut–liver cross talk (GLCT). We hypothesized that similar could be translated short bowel syndrome (SBS). Methods Using piglets, we developed novel...
To compare outcomes for complicated appendicitis treated with early versus interval appendectomy and to identify which patients would likely benefit from appendectomy.A retrospective review of was performed 2010 2015. Patients were divided into (EA) (IA) groups. We compared demographics, complications outcomes. Pearson's Chi square analysis Student's T test performed.We identified 316 (EA group 53% vs. IA 47%). Interval had longer symptom duration [IA 3.8 EA 2.3 days (p = 0.0001)], increased...