A5044161142- Esophageal and GI Pathology
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Bone Tissue Engineering Materials
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Mesenchymal stem cell research
- Infectious Aortic and Vascular Conditions
- Cardiac Structural Anomalies and Repair
- Hernia repair and management
- Bariatric Surgery and Outcomes
- Abdominal Surgery and Complications
- Urological Disorders and Treatments
- Metastasis and carcinoma case studies
- Mechanical Circulatory Support Devices
- Gastrointestinal disorders and treatments
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
Fundacion Favaloro Hospital Universitario
2014-2024
Favaloro Foundation
2016-2024
McGowan Institute for Regenerative Medicine
2010-2022
University of Pittsburgh
2008-2022
Favaloro University
2011-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2020
University of Belgrano
2017
University of Pittsburgh Medical Center
2008-2012
Hy-Line (United States)
2009
Cohera Medical (United States)
2008
As a result of injury caused by chronic gastroesophageal reflux, Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma are rapidly increasing problems in the United States. The current standard care involves esophagectomy, procedure associated high morbidity, negative impact on long term quality life, mortality rate 1-6 percent. An entirely endoscopic technique for circumferential, segment en bloc removal mucosa submucosa subsequent placement biologic scaffold material...
Limited autologous vascular graft availability and poor patency rates of synthetic grafts for bypass or replacement small-diameter arteries remain a concern in the surgical community. These limitations could potentially be improved by tissue engineering approach. We report here our progress development vivo testing stem-cell-based tissue-engineered arterial applications. Poly(ester urethane)urea scaffolds (length = 10 mm; inner diameter 1.2 mm) were created thermally induced phase separation...
Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These provide robust mechanical strength and quickly incorporated into host tissue; factors that contribute to reduced recurrence rates. However, such cause a foreign body response with the associated complications fibrosis patient discomfort. In contrast, surgical naturally occurring extracellular matrix (ECM) constructive tissue remodeling, but lack materials. A method applying porcine dermal...
Abstract There remains a great need for vascular substitutes small‐diameter applications. The use of an elastomeric biodegradable material, enabling acute antithrombogenicity and long‐term in vivo remodeling, could be beneficial this purpose. Conduits (1.3 mm internal diameter) were obtained by electrospinning poly(ester urethane)urea (PEUU), luminally immobilizing non‐thrombogenic, 2‐methacryloyloxyethyl phosphorylcholine (MPC) copolymer. Platelet adhesion was characterized vitro after...
Biologic scaffolds composed of extracellular matrix (ECM) have been used to facilitate repair or remodeling numerous tissues, including the esophagus. The theoretically ideal scaffold for tissue is ECM derived from particular be treated, that is, site-specific homologous ECM. preference potential advantage use remains unknown in esophageal location. objective present study was characterize vitro cellular response and vivo host a (eECM) versus nonhomologous ECMs small intestinal submucosa...
Abstract One of the major limitations in tissue engineering is cell sourcing. Multipotent progenitor cells appear to have many promising features for that purpose. Mechanical stimulation known play an important role determining phenotype. The aim this work was investigate effects cyclic stretch on rat bone marrow derived (BMPC) morphology and smooth muscle‐directed differentiation within a three‐dimensional fibrin matrix. BMPCs were suspended gel, pipetted into trough Flexcell™ Tissue‐Train™...
Tracheal loss is a source of significant morbidity for affected patients with no acceptable solution. Interest in engineering tracheal transplants has created demand small animal models orthotopic transplantation. Here, we examine the use decellularized graft murine model replacement. Fresh or tracheas harvested from age-matched female donor C57BL/6 mice were transplanted into syngeneic recipients. Tracheas using repeated washes water, 3% Triton X-100, and 3 M NaCl under cyclic pressure...
The manual seeding of cells onto a biodegradable scaffold by pipetting is an effective method cell seeding. However, the widespread use and ultimate clinical utility this technique limited operator variability. This study was conducted to evaluate operator-independent vacuum-seeding for in upcoming trial. Using bone marrow-derived mononuclear cells, we achieved comparable manually seeded scaffolds terms cellular attachment, distribution, viability vacuum-seeded grafts at vacuum pressures -25...