A5038428593- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Identification and Quantification in Food
- Hernia repair and management
- Congenital gastrointestinal and neural anomalies
- Anatomy and Medical Technology
- Clinical Nutrition and Gastroenterology
- Literature, Film, and Journalism Analysis
- Tannin, Tannase and Anticancer Activities
- Biomedical Ethics and Regulation
- Reconstructive Surgery and Microvascular Techniques
- Sympathectomy and Hyperhidrosis Treatments
- biodegradable polymer synthesis and properties
- Circular RNAs in diseases
Imperial College London
2017-2022
University of Pittsburgh
2011-2020
McGowan Institute for Regenerative Medicine
2011-2020
NIHR Imperial Biomedical Research Centre
2020
Target (United States)
1995
Uncontrolled inflammation is a major pathological factor underlying range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery immunosuppressive drugs to inflamed tissue in non-invasive manner offers significant promise reduce severe side effects caused by systemic administration. Here, neutrophil-mediated system able transport drug-loaded nanocarriers exploiting the inherent ability neutrophils migrate inflammatory reported. This...
Abstract Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell‐derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, show reduced immunogenicity compared other synthetic nanoparticles. Although initial clinical trials ongoing, the use EVs for therapeutic applications may limited due undesired off‐target...
Despite advances in therapeutic options, more than half of all patients with ulcerative colitis [UC] do not achieve long-term remission, many require colectomy, and the disease still has a marked negative impact on quality life. Extracellular matrix [ECM] bioscaffolds facilitate functional repair soft tissues by mechanisms that include mitigation pro-inflammatory macrophage phenotype mobilization endogenous stem/progenitor cells. The aim present study was to determine if an ECM hydrogel...
To investigate the growth and differentiation of intestinal stem cells on a novel tubular scaffold in vitro vivo.Intestinal progenitor from mice or humans were cultured with myofibroblasts, macrophages and/or bacteria, evaluated via omental implantation. Mucosal regeneration was dogs after rectal mucosectomy followed by implantation.Intestinal differentiated into crypt-villi structures scaffold. Differentiation coverage enhanced coculture probiotic while implanted scaffolds mucosal dog...
Extracellular matrix (ECM) derived from mammalian tissues has been utilized to repair damaged or missing tissue and improve healing outcomes. More recently, processing of ECM into hydrogels expanded the use these materials include platforms for 3-dimensional cell culture as well injectable therapeutics that can be delivered by minimally invasive techniques fill irregularly shaped cavities. At cellular level, initiate a multifaceted host response includes recruitment endogenous...
Biologic scaffolds composed of extracellular matrix (ECM) have been used to facilitate repair or remodeling numerous tissues, including the esophagus. The theoretically ideal scaffold for tissue is ECM derived from particular be treated, that is, site-specific homologous ECM. preference potential advantage use remains unknown in esophageal location. objective present study was characterize vitro cellular response and vivo host a (eECM) versus nonhomologous ECMs small intestinal submucosa...
Zebrafish embryos provide a unique opportunity to visualize complex biological processes, yet conventional imaging modalities are unable access intricate biomolecular information without compromising the integrity of embryos. Here, we report use confocal Raman spectroscopic for visualization and multivariate analysis extracted from unlabeled zebrafish We outline broad applications this method in: (i) visualizing distribution whole in three dimensions, (ii) resolving anatomical features at...
Abstract Gastrointestinal pathologies, injuries, and defects affect millions of individuals each year. While there are diverse treatment options for these individuals, no ideal solution exists. The repair or replacement gastrointestinal tissue, therefore, represents a large unmet clinical need. Biomaterials derived from extracellular matrix (ECM) scaffolds have been effectively used to replace numerous tissues throughout the body in both preclinical studies. Such prepared decellularized...