A5084255852- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- MicroRNA in disease regulation
- Celiac Disease Research and Management
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Inhalation and Respiratory Drug Delivery
- Fibroblast Growth Factor Research
- Infant Nutrition and Health
- Microscopic Colitis
- Circular RNAs in diseases
- Advanced Drug Delivery Systems
- Digestive system and related health
- Pneumonia and Respiratory Infections
- Glaucoma and retinal disorders
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Liver Diseases and Immunity
- Galectins and Cancer Biology
- Nanoparticle-Based Drug Delivery
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021-2025
Helmholtz Institute for Pharmaceutical Research Saarland
2017-2023
Helmholtz Centre for Infection Research
2017-2023
Saarland University
2017-2023
Nanotherapeutics (United States)
2019
Imperial College London
2014-2018
NIHR Imperial Biomedical Research Centre
2014-2015
ETH Zurich
2010-2013
Université de Montréal
2010
Laboratoire de Biophotonique et Pharmacologie
2010
Oxidative stress is central to neuronal damage in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In consequence, activation of the cerebral oxidative defence considered a promising strategy therapeutic intervention. Here we demonstrate that flavone luteolin confers neuroprotection against via nuclear factor erythroid-2-related 2 (Nrf2), transcription maintenance cellular redox homeostasis. Luteolin protects rat neural PC12 glial C6 cells from...
Abstract Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell‐derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, show reduced immunogenicity compared other synthetic nanoparticles. Although initial clinical trials ongoing, the use EVs for therapeutic applications may limited due undesired off‐target...
Abstract Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs usually stored at −80 °C which limits potential clinical applicability. Freeze‐drying of striving for long‐term stable formulations is therefore studied. The most appropriate formulation parameters identified in freeze‐thawing studies with two different EV types. After a freeze‐drying feasibility study, four lyophilized tested storage stability up to 6 months....
Extracellular vesicles are membranous structures shed by almost every living cell. Bacterial gram-negative outer membrane (OMVs) and gram-positive (MVs) play important roles in adaptation to the surrounding environment, cellular components' exchange, transfer of antigens virulence factors, infection propagation. Streptococcus pneumoniae is considered one priority pathogens, with a global health impact due increase burden growing antibiotic resistance. We isolated MVs produced from S....
Extracellular vesicles (EVs) are natural nanoparticles that play important roles in intercellular communication and increasingly studied for biosignalling, pathogenesis therapy. Nevertheless, little is known about optimal conditions their transfer storage, the potential impact on preserving EV-loaded cargoes. We present first comprehensive stability assessment of different widely available types EVs during various storage including -80 °C, 4 room temperature, freeze-drying (lyophilisation)....
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors (TLRs) enable innate cells, such as macrophages, to recognize wide variety microbial ligands, thereby promoting inflammation. The interaction with macrophages immunosuppressive resolution phase upon prolonged TLR activation is unknown. Treatment human alveolar (AMs) synthetic GC dexamethasone (Dex) did not alter...
During infection, inflammation is an important contributor to tissue regeneration and healing, but it may also negatively affect these processes should chronic overstimulation take place. Similar issues arise in inflammatory gastrointestinal diseases such as bowel or celiac disease, which show increasing incidences worldwide. For dispositions, probiotic microorganisms, including lactobacilli, are studied adjuvant therapy counterbalance gut dysbiosis. However, not all who affected can benefit...
Probiotic bacteria, such as Lactobacilli, have been shown to elicit beneficial effects in various tissue regeneration applications. However, their formulation living bacteria is challenging, and therapeutic use proliferating microorganisms especially limited immunocompromised patients. Here, we propose a new avenue circumvent these shortcomings by developing bacteriomimetic hydrogel based on membrane vesicles (MVs) produced Lactobacilli. We coupled MVs from Lactobacillus plantarum casei,...