A5061001313- Extracellular vesicles in disease
- Polyoxometalates: Synthesis and Applications
- Bacterial Infections and Vaccines
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Gut microbiota and health
- Infant Nutrition and Health
- Cancer Treatment and Pharmacology
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Protist diversity and phylogeny
- Advanced Breast Cancer Therapies
- RNA Interference and Gene Delivery
- Legionella and Acanthamoeba research
Saarland University
2020-2023
Helmholtz Institute for Pharmaceutical Research Saarland
2020-2023
Helmholtz Centre for Infection Research
2020-2023
During infection, inflammation is an important contributor to tissue regeneration and healing, but it may also negatively affect these processes should chronic overstimulation take place. Similar issues arise in inflammatory gastrointestinal diseases such as bowel or celiac disease, which show increasing incidences worldwide. For dispositions, probiotic microorganisms, including lactobacilli, are studied adjuvant therapy counterbalance gut dysbiosis. However, not all who affected can benefit...
Probiotic bacteria, such as Lactobacilli, have been shown to elicit beneficial effects in various tissue regeneration applications. However, their formulation living bacteria is challenging, and therapeutic use proliferating microorganisms especially limited immunocompromised patients. Here, we propose a new avenue circumvent these shortcomings by developing bacteriomimetic hydrogel based on membrane vesicles (MVs) produced Lactobacilli. We coupled MVs from Lactobacillus plantarum casei,...
In 2019, it was estimated that 2.5 million people die from lower tract respiratory infections annually. One of the main causes these is Staphylococcus aureus, a bacterium can invade and survive within mammalian cells. S. aureus intracellular are difficult to treat because several classes antibiotics unable permeate through cell wall reach pathogen. This condition increases need for new therapeutic avenues, able deliver efficiently. this work, we obtained outer membrane vesicles (OMVs)...
Abstract There is a lack of efficient therapies to treat increasingly prevalent autoimmune diseases, such as inflammatory bowel disease and celiac disease. Membrane vesicles (MVs) isolated from probiotic bacteria have shown tremendous potential for treating intestinal diseases. However, possible dilution effects rapid elimination in the gastrointestinal tract may impair their application. A cell‐free anti‐inflammatory therapeutic system—probiomimetics—based on MVs ( Lactobacillus casei...
Previous work on murine models and humans demonstrated global as well tissue-specific molecular ageing trajectories of RNAs. Extracellular vesicles (EVs) are membrane mediating the horizontal transfer genetic information between different tissues. We sequenced small regulatory RNAs (sncRNAs) in two mouse plasma fractions at five time points across lifespan from 2–18 months: (1) sncRNAs that free-circulating (fc-RNA) (2) bound outside or inside EVs (EV-RNA). Different sncRNA classes exhibit...
Outer membrane vesicles are small, lipid-based shed from the outer of Gram-negative bacteria.
Introduction The INGE-B trial (NCT02894398) aimed to confirm the efficacy and safety data from PALOMA trials for patients treated first line (1L) with palbociclib (PAL) letrozole or 1L later PAL fulvestrant. In addition, on combination of anastrozole, exemestane (1L), (later line) was investigated. Methods prospective, multicenter, multi-cohort phase 2 enrolled adult locally advanced, inoperable, metastatic HR+/HER2- breast cancer in Germany. primary endpoint clinical benefit rate (CBR)...
Previous work on murine models and human demonstrated global as well tissue-specific molecular aging trajectories in solid tissues body fluids 1–8 . Extracellular vesicles like exosomes play a crucial role communication information exchange between such systemic factors 9,10 We sequenced freely circulating vesicle-bound small regulatory RNAs mice at five time points across the average life span from 2 to 18 months. Intriguingly, each RNA class exhibits unique patterns, which showed...