Cosima Brucker
A5062599982- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sperm and Testicular Function
- Complementary and Alternative Medicine Studies
- Pelvic floor disorders treatments
- Medical and Health Sciences Research
- BRCA gene mutations in cancer
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- HER2/EGFR in Cancer Research
- Reproductive Health and Contraception
- Anorectal Disease Treatments and Outcomes
- Ovarian cancer diagnosis and treatment
- Menopause: Health Impacts and Treatments
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Health and Medical Studies
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Pelvic and Acetabular Injuries
- Pregnancy and preeclampsia studies
Paracelsus Medizinische Privatuniversität
2015-2024
Klinik für Frauenheilkunde
2010-2024
Nuremberg Hospital
2014-2024
Clinica Universidad de Navarra
2024
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2016
Universitäts Frauenklinik
1993-2016
Comprehensive Cancer Center Erlangen
2011-2016
Universitätsklinikum Erlangen
2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
Georg Simon Ohm University of Applied Sciences Nuremberg
2013
Minimally invasive surgery in cervical cancer has demonstrated recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival patients with stage IB1 (FIGO 2009) undergoing vs minimally radical hysterectomy. As secondary objective, we aimed investigate association between protective surgical maneuvers and risk relapse. We obtained data from 1272 that...
Increasing effort has been put in the implementation and certification of breast centers order to establish standardized, quality assured health care for cancer patients. The aim this analysis was investigate whether patients treated certified (CBC) have a favorable prognosis as compared outside treatment units.The data 3,940 with invasive nonmetastatic were analyzed regard differences patient tumor characteristics crude overall survival according diagnosis or CBC Middle Franconia, Germany....
The multicenter, randomized, phase IV, intergroup AGO-B WSG PreCycle trial (NCT03220178) evaluated the impact of CANKADO-based electronic patient-reported outcome (ePRO) assessment on quality life (QoL) in hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer (MBC) patients receiving palbociclib and an aromatase inhibitor + fulvestrant. CANKADO PRO-React, a European Union-registered medical device, is interactive autonomous...
<h3>Objective</h3> The aim of this study was to compare the incidence intra-operative and post-operative complications in open minimally invasive radical hysterectomy for patients with early-stage cervical cancer. <h3>Methods</h3> Data were collected from SUCCOR database 1272 stage IB1 cancer (International Federation Gynecology Obstetrics (FIGO), 2009) who underwent Europe between January 2013 December 2014. We reviewed duration surgeries, estimated blood loss, length hospital stay,...
In Brief Objective: To investigate endometrial safety by assessment of biopsy samples and the tolerability efficacy special Actaea or Cimicifuga racemosa extract (CR BNO 1055). Design: Four hundred postmenopausal women with symptoms related to estrogen deficiency were enrolled into a prospective, open-label, multinational, multicenter study. Treatment duration (daily dose corresponds 40 mg herbal drug) was 52 weeks. determine probability hyperplasia more serious adverse outcome, point...
In order to assess the role of binucleate giant oocytes for generating digynic triploidy, we studied their frequency, maturation patterns and chromosomal complements at metaphase II (MII) or after fertilization.Uncleaved, zygotes were incubated with podophyllotoxin vinblastine, treated hypotonic solution fixed by a gradual fixation method. Giant MII directly subjected treatment. The chromosomes stained Giemsa.A total 7065 collected during study period, which 18 (0.26%) classified as cells....
Objectives To investigate the real-life clinical experience of NuvaRing® users in Germany.Methods An open-label, prospective, uncontrolled, non-randomized, multicentre post-marketing surveillance study was conducted by 1204 gynaecologists amongst 5823 women requesting contraception. The underwent routine examinations and contraceptive counselling, were assessed after three six cycles use.Results: Good cycle control observed there a reduction irregularity inter-menstrual bleeding, bleeding...
Abstract Background Due to the lack of prospective data, current treatment male breast cancer (MBC) is based on information obtained from retrospective analysis or by extrapolation studies female patients. In this prospectively enrolled cohort study, we retrospectively examined survival effect tamoxifen in MBC Methods 448 patients with were treated between May 2009 and June 2018. The primary endpoint was disease-free (DFS). Results Between 2018, men identified, a median age at diagnosis 69...
Intra-ovarian regulation of follicular maturation is modulated by various factors. Among these, growth factors are important local actors. We examined the immunohistochemical localization transforming factor alpha (TGF-alpha), epidermal (EGF) and receptor (EGF-R) in 18 human ovaries. The concentration TGF-alpha EGF fluid was measured ELISA. detected oocytes primordial early preantral follicles. Furthermore, staining observed granulosa cells follicles theca preantral, antral preovulatory...
Previously, we provided evidence for the presence of a class muscarinic receptors on human luteinized granulosa cells (human GC) that is linked to transient increases in intracellular free calcium levels, but not steroid production. The precise nature receptor known, and neither its function nor source natural ligand acetylcholine (ACh) clear. To address these issues used RT-PCR approaches isolated complementary DNAs corresponding M1 subtype from reverse transcribed GC messenger ribonucleic...
The growing popularity and acceptance of integrative medicine is evident both among patients the oncologists treating them. As little data are available regarding health-care professionals' knowledge, attitudes, practices relating to topic, a nationwide online survey was designed.Over period 11 weeks (from July 15 September 30, 2014) self-administered, 17-item sent all 676 members Research Group on Gynecological Oncology (Arbeitsgemeinschaft Gynäkologische Onkologie) in German Cancer...
Background. Breast cancer patients often use complementary and alternative medicine, but few prospectively collected data on the topic are available specifically for postmenopausal breast patients. A large prospective study was therefore conducted within a noninterventional in order to identify characteristics of interested integrative medicine. Methods. The EvAluate-TM is prospective, multicenter which treatment with aromatase inhibitor letrozole evaluated women hormone receptor–positive...
Abstract Adjuvant treatment of patients with early-stage breast cancer (BC) should include an aromatase inhibitor (AI). Especially a high recurrence risk might benefit from upfront therapy AI for minimum five years. Nevertheless, not much is known about the patient selection this population in clinical practice. Therefore, study analyzed prognosis and characteristics postmenopausal selected five-year letrozole therapy. From 2009 to 2011, 3529 were enrolled into adjuvant phase IV PreFace...
Introduction Circulating levels of the antiangiogenic protein vasoinhibin, a fragment prolactin, are interest in vasoproliferative retinopathies, preeclampsia, and peripartum cardiomyopathy; however, it is difficult to determine circulating vasoinhibin due lack quantitative assays. Methods This study used human serum samples assess concentration bioactivity using novel enzyme-linked immunosorbent assay (ELISA) for which employs an anti-vasoinhibin monoclonal antibody, umbilical vein...