A5003246186- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Sperm and Testicular Function
- Pelvic floor disorders treatments
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Medical and Health Sciences Research
- Ovarian function and disorders
- Breast Lesions and Carcinomas
- Tissue Engineering and Regenerative Medicine
- Reproductive Health and Technologies
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Klinik für Frauenheilkunde
2015-2024
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2014-2024
Universitäts Frauenklinik
2010-2022
Klinik und Poliklinik für Urologie
2014-2020
Universitätsklinik für Frauenheilkunde und Geburtshilfe
1989-2020
University Medical Center
2020
Centrum für Integrierte Onkologie
2005-2019
Asklepios Kliniken Hamburg
2019
Background— Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of vascular endothelial growth factor receptor 1, induces a preeclampsia-like phenotype experimental models circulates at elevated levels human preeclampsia. Removing sFlt-1 may benefit women with very preterm (<32 weeks) Methods Results— We first show that negatively charged dextran...
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-1 (sFlt-1) an antiangiogenic protein believed to mediate the signs and symptoms preeclampsia. We conducted open pilot study evaluate safety potential efficacy therapeutic apheresis with plasma-specific dextran sulfate column remove circulating sFlt-1 in 11 pregnant women (20–38 years age) very preterm preeclampsia (23–32 weeks gestation, systolic BP ≥140 mmHg or diastolic ≥90 mmHg, new onset...
Objective Laparoscopic/robotic radical hysterectomy has been historically considered oncologically equivalent to open for patients with early cervical cancer. However, a recent prospective randomized trial (Laparoscopic Approach Cervical Cancer, LACC) demonstrated significant inferiority of the minimally invasive approach. The aim this study is evaluate oncologic outcomes combined laparoscopic-vaginal hysterectomy. Methods Between August 1994 and December 2018, cancer were treated using...
Diminished ovarian reserve has become a major cause of infertility. Anti-Mullerian hormone (AMH) seems to be promising candidate assess and predict the response controlled hyperstimulation (COH). This prospective study was conducted evaluate relevance AMH in routine IVF program.Three hundred sixteen patients were prospectively enrolled enter their first IVF/ICSI-cycle. Age, FSH-, inhibin B- AMH-levels predictive values for clinical pregnancy rate compared by discriminant analyses.A total 132...
BACKGROUND: In contrast to the technique of conventional freezing, vitrification spermatozoa requires high cooling rates (720 000°K/min), which could be damaging for spermatozoa. The aim our study was compare slowly frozen and vitrified in terms their post‐thaw DNA integrity motility. METHODS: Semen samples were prepared according routine swim‐up divided into aliquots comparison fresh, conventionally from same ejaculate presence or absence cryoprotectants. Spermatozoa motility determined....
Endometrioid endometrial carcinoma, the most common form of cancer, usually develops out a typical sequence hyperplasias. The underlying cause these hyperplasias is relative predominance estrogen combined with insufficient progesterone levels. Typical causes include corpus luteum insufficiency/anovulatory cycles (premenopause), polycystic ovary syndrome and obesity metabolic (aromatase conversion ovarian androgens in adipose tissue), inappropriate hormone therapy post menopause (insufficient...
Background Most patients with epithelial ovarian cancer (EOC) relapse despite primary debulking surgery and chemotherapy (CT). Autologous dendritic cell immunotherapy (DCVAC) can present tumor antigens to elicit a durable immune response. We hypothesized that adding parallel or sequential DCVAC CT stimulates antitumor immunity improves clinical outcomes in EOC. Based on the interim results of DCVAC/OvCa administration accommodate increased interest maintenance treatment EOC, trial was...
ABSTRACT: The aim of this study was to develop and test the standardized aseptic technology permeable cryoprotectant‐free vitrification human spermatozoa in capillaries (for intracytoplasmic sperm injection [ICSI] or vitro fertilization [IVF]). To effect on basic parameters, each 68 swim‐up–prepared ejaculates from oligo‐astheno‐terato‐zoospermic patients were aliquoted distributed into 3 groups: 1) nontreated control, 2) 10 μL cryopreserved by slow conventional freezing with...
Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed meet patient demand often are fragmented along disciplinary lines. We quantify assets gaps in oncofertility care a global scale.Survey-based questionnaires were provided 191 members of the Consortium Global Partners Network, National Institutes Health-funded organization. Responses analyzed measure trends regional subtleties...
Purpose: This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of Deutsche Krebsgesellschaft (DKG, German Cancer Society) Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, Society Gynecology Obstetrics). The number cases with vulvar cancer on rise, but because former rarity this condition resulting lack literature a high level evidence, in many areas knowledge optimal clinical management...
Chemotherapy for recurrent ovarian carcinoma (ROC) produces response rates of 10-80% depending on the prevalence platinum resistance. Most patients relapse within 1 year and median progression-free survival (PFS) is generally no more than 6 months. Previous pretherapeutic chemosensitivity assays mostly failed to improve outcome with ROC. Newly developed ATP show promising retrospective correlation clinical outcome. We report here first results assay-directed chemotherapy in Therapy was...
The aims of this investigation were to test a novel technology comprising cryoprotectant-free vitrification the spermatozoa rainbow trout and study ability sucrose components seminal plasma protect these cells from cryo-injuries. Spermatozoa isolated vitrified using three different media: Group 1: standard buffer for fish spermatozoa, Cortland® medium (CM, control); 2: CM + 1% BSA 40% plasma; 3: 0.125 m sucrose. For cooling, 20-μl suspensions each group dropped directly into liquid nitrogen....
At present, there are three ways to determine effectively the quality of cryopreservation procedure using ovarian tissue before re-implantation treatment: evaluation follicles after post-thawing xenotransplantation SCID mouse, in-vitro culture in a large volume medium under constant agitation and on embryonic chorio-allantoic membrane within hen's eggs. The aim this study was compare two methods, vitro chorioallantoic (CAM) cryopreserved human medulla-contained medulla-free cortex. Ovarian...
This study aimed to investigate Sugarbaker's peritoneal cancer index (PCI) as a prognostic indicator for the resectability of ovarian carcinoma (OC), depicted in using completeness cytoreduction score (CCS).Currently, intraoperative assessment operability OC surgery is primarily subjective measurement that dependent on surgeon.The retrospective data from 98 patients with International Federation Gynecology and Obstetrics (FIGO) III IV who had received between January 2010 December 2011 were...
<b>Purpose:</b> Official guideline published and coordinated by the German Society of Gynecology Obstetrics (DGGG). Due to their rarity heterogeneous histopathology uterine sarcomas remain challenging tumors manage need a multidisciplinary approach. To our knowledge so far there is no evidence-based on appropiate management these tumors. <b>Methods:</b> This S2k-guideline work an representative committee experts from variety different professions who were commissioned DGGG carry out...
The appropriate surgical technique to treat patients with uterine fibroids is still a matter of debate as the potential risk incorrect treatment if histological examination detects sarcoma instead fibroids. published epidemiology for set against incidence accidental findings during surgery International comments on this topic are discussed and incorporated into assessment by German Society Gynecology Obstetrics (DGGG). ICD-O-3 version 2003 was used anatomical topographical coding sarcomas,...