A5079098518- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Bone health and treatments
- Surgical Simulation and Training
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Pancreatitis Pathology and Treatment
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Biblical Studies and Interpretation
- Innovations in Medical Education
- Pancreatic function and diabetes
- Estrogen and related hormone effects
- Historical and Linguistic Studies
- Islamic Studies and History
- Diet, Metabolism, and Disease
- Cancer-related Molecular Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Diversity and Career in Medicine
- Wittgensteinian philosophy and applications
- African cultural and philosophical studies
- Musicology and Musical Analysis
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
University of Nottingham
2000-2024
University of California, San Diego
1979-2023
Northwestern University
2002-2021
Sheffield Teaching Hospitals NHS Foundation Trust
2021
Deakin University
2012-2019
Barwon Health
2007-2019
Temple University
2018
University of Salford
2014-2017
Community Living
2016
Harrogate and District NHS Foundation Trust
2016
Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical activity in advanced breast cancer that overexpresses HER2. We investigated its efficacy and safety after excision of early-stage completion chemotherapy.
Skeletal complications are a major clinical manifestation of multiple myeloma. These caused by soluble factors that stimulate osteoclasts to resorb bone. Bisphosphonates such as pamidronate inhibit osteoclastic activity and reduce bone resorption.Patients with stage III myeloma at least one lytic lesion received either placebo or (90 mg) four-hour intravenous infusion given every four weeks for nine cycles in addition antimyeloma therapy. The patients were stratified according whether they...
13-cis-Retinoic acid has been reported to be effective in treating oral leukoplakia. We randomly assigned 44 patients with this disease receive 13-cis-retinoic (24 patients) or placebo (20), 1 2 mg per kilogram of body weight day for three months, and followed them six months. There were major decreases the size lesions 67 percent (16 those given drug 10 (2 (P = 0.0002); dysplasia was reversed 54 (13 group 0.01). The clinical response correlated histologic 56 (9 16) evaluated. Relapse...
Data suggest that the adjuvant use of bisphosphonates reduces rates recurrence and death in patients with early-stage breast cancer. We conducted a study to determine whether treatment zoledronic acid, addition standard therapy, would improve disease outcomes such patients.In this open-label phase 3 study, we randomly assigned 3360 receive systemic therapy either or without acid. The acid was administered every 4 weeks for 6 doses then months complete 5 years treatment. primary end point...
The purpose of the study was to identify a group operations which general surgery residency program directors believed residents should be competent perform by end 5 years training and then ascertain actual resident experience with these procedures during their training.There is concern about adequacy surgeons in United States. American Board Surgery Association Program Directors undertook determine what operative consider essential practice we measured graduating those procedures, as...
Purpose To document the rate and outcome of trastuzumab-associated cardiac dysfunction in patients following 1 or 2 years adjuvant therapy. Patients Methods The Herceptin Adjuvant (HERA) trial is a three-arm, randomized comparing year trastuzumab with observation 5,102 human epidermal growth factor receptor (HER2) –positive early-stage breast cancer. Cardiac function was closely monitored. Eligible had left ventricular ejection fraction (LVEF) ≥ 55% at study entry neoadjuvant chemotherapy...
Objective To examine, in the Veterans Health Administration (VHA), relation between surgical volume and outcome eight commonly performed operations of intermediate complexity. Summary Background Data In multihospital health care systems such as VHA, consideration is often given to closing low-volume services, with assumption that better outcomes are achieved hospitals larger volumes. Literature data support this intermediate-complexity either limited or controversial. Methods The VHA...
The objective of this study is to assess the effect oral ibandronate on bone pain and quality life in women with metastatic disease from breast cancer. In two double-blind, placebo-controlled studies, 564 patients were randomised receive ibandronate, 50mg once daily, or placebo for up 96 weeks. Throughout we assessed (on a 5-point scale 0=none 4=intolerable), analgesic use (7-point scale) (European Organisation Research Treatment Cancer Quality Life Questionnaire-C30 [EORTC QLQ-C30],...
Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has shown inhibit growth in some cell lines but not studied cancer. We hypothesized that apigenin would vitro.Apigenin caused both time- and concentration-dependent inhibition of DNA synthesis proliferation four lines. Apigenin induced G2/M phase cycle arrest. reduced levels cyclin A, B, phosphorylated forms cdc2 cdc25, which are all proteins required for...
A prospective evaluation of emergency protacaval shunt has been conducted in 180 unselected, consecutive patients with cirrhosis and bleeding varices who were operated on between 1963 1978. An extensive diagnostic work-up was completed within three to seven hours admission the department, operation undertaken a mean 7.81 hours. program lifelong follow-up such that current status 97% is known. On each patient, 220 categories data collected entered into computer for analysis. admission, 49%...
Abstract Purpose: Denosumab was shown to be superior zoledronic acid in preventing skeletal related events (SRE) patients with breast cancer and bone metastases a randomized, double-blind phase III study. We evaluated further results from this study complications health-related quality of life (HRQoL). Experimental Design: Patients were randomized 1:1 receive subcutaneous denosumab 120 mg (n = 1,026) intravenous placebo, or 4 1,020) placebo every weeks. Analyses reported here include the...
Preface Acknowledgements 1. Understanding Another Culture: others and ourselves A procedure from an aesthetic point of view 'Found in Translation' 2. Foundations Modern Philosophy: Ethnophilosophy the 'negritude' movement Critical, scientific philosophy Sage 3. Liberation Postcolonial African humanism socialism thought The question 'race' 4. Moral Philosophy 1: Community Justice: Persons, individualism communalism Suffering injustice Poverty human development 5. II: Truth, Justice...