A5069383705- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- Ovarian cancer diagnosis and treatment
- AI in cancer detection
- Medical and Health Sciences Research
- MRI in cancer diagnosis
- T-cell and B-cell Immunology
- Digital Radiography and Breast Imaging
- Music Therapy and Health
- Cervical Cancer and HPV Research
- CAR-T cell therapy research
- Surgical Simulation and Training
- Cancer Risks and Factors
- Cancer survivorship and care
- BRCA gene mutations in cancer
Klinik und Poliklinik für Kinder- und Jugendmedizin
2025
Klinikum Frankfurt Höchst
2020-2024
Goethe University Frankfurt
2009-2021
University Hospital Frankfurt
2020-2021
ORCID
2021
Heidelberg University
2011-2020
University Hospital Heidelberg
2011-2020
Frauenklinik Heidelberg
2005-2020
Universitäts Frauenklinik
2008-2020
National Center for Tumor Diseases
2011-2019
Neoadjuvant systemic treatment (NST) elicits a pathologic complete response in 40%-70% of women with breast cancer. These patients may not need surgery as all local tumor has already been eradicated by NST. However, nonsurgical approaches, including imaging or vacuum-assisted biopsy (VAB), were able to accurately identify without residual cancer the axilla. We evaluated feasibility machine learning algorithm (intelligent VAB) exceptional responders NST.We trained, tested, and validated using...
The multicenter, randomized, phase IV, intergroup AGO-B WSG PreCycle trial (NCT03220178) evaluated the impact of CANKADO-based electronic patient-reported outcome (ePRO) assessment on quality life (QoL) in hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer (MBC) patients receiving palbociclib and an aromatase inhibitor + fulvestrant. CANKADO PRO-React, a European Union-registered medical device, is interactive autonomous...
Aberrant DNA methylation constitutes a well-established epigenetic marker for breast cancer. Changes in early cancer development may be clinically relevant detection and prognosis-based therapeutic decisions. In the present study, combination of methyl-CpG immunoprecipitation (MCIp) human CpG island (CGI) arrays was applied to compare genome-wide profiles 10 low-grade situ invasive cancers against normal samples. total, 214 CGIs were found hypermethylated ≥6 tumors. Functional term...
To evaluate virtual touch tissue imaging quantification (VTIQ) as a new elastography method concerning its intra- and interexaminer reliability ability to differentiate benign from malignant breast lesions in comparison combination with ultrasound (US) B-mode reporting data system (BI-RADS) assessment. US VTIQ were performed by two examiners 103 women 104 lesions. Intra- of was assessed. The area under the receiver operating curve (AUC), sensitivity, specificity, positive predictive value...
Introduction Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It rare disease, representing less than 1% of all the female genital tract. Similar cervical (CIN), there are three different grades VAIN. VAIN 1 also known as low-grade squamous lesion (LSIL), whereas 2 and 3 both represent high-grade lesions (HSIL). Risk factors for development similar those neoplasia, i.e. promiscuity, starting sexual activity at an early age, tobacco...
Background: Ovarian cancer (OvCa) is a highly aggressive malignoma with tumor-promoting microenvironment.Infiltration of polymorphonuclear neutrophils (PMN) frequently seen, raising the question their impact on tumor development.In that context, effects PMN human ovarian cells were assessed.Methods: Human epithelial incubated PMN, lysate or neutrophil elastase.Morphological alterations observed by time-lapse video-microscopy, and underlying molecular mechanism was analyzed flow cytometry...
Background: Breast cancer represents the most common malignant disease in women worldwide. As currently systematic palliative treatment only has a limited effect on survival rates, concept of health-related quality life (HRQoL) is gaining more and importance therapy setting metastatic breast cancer. One major patient-reported outcomes (PROs) for measuring HRQoL patients with provided by European Organization Research Treatment Cancer (EORTC). Currently, paper-based surveys still predominate,...
This prospective cohort study was carried out to develop a German version of the Breast Cancer Treatment Outcome Scale (BCTOS) and examine relations aesthetic functional outcome after breast conserving surgery with quality life (QoL).The included 189 patients one-sided, early stage cancer. A factor analysis indicated three internally consistent scales BCTOS: Aesthetic Status, Functional Status Sensitivity Status.QoL measured by EORTC Quality Life Questionnaire C30-BR23 (EORTC). All BCTOS...
IntroductionEvaluation of oncological outcome and prognostic factors patients with primary breast cancer treated at a certified academic unit.Patients methodsWe prospectively collected data 3338 patients, diagnosed between 01.01.2003 31.12.2010 the Breast Unit Heidelberg, Germany, in order to analyze clinical practice. We evaluated local control rate (LCR), disease-free survival (DFS), distant (DDFS), observed overall (OS) age-adjusted relative (ROS). In addition, impact known on these...
Considering the diverse functions of B cells, responses to tumor-associated antigens (TAA) have been thought be main source cell-mediated antitumor immunity. Polymorphic epithelial mucin (MUC1) is considered one most specific TAA in patients with breast cancer. The present study aims dissect level and subclasses naturally occurring anti-MUC1 antibodies regard tumor biologic parameters, clinical characteristics overall survival. In 288 primary, non-metastatic cancer patients, pretreatment...
Objective: To evaluate the role of c- myc oncogene amplifications in progression invasive breast carcinomas. Methods: gene copy number was evaluated a series 49 primary carcinomas and corresponding local recurrences using fluorescence situ hybridisation. Results: 11 (22%) harboured amplifications; these tumours typically were hormone receptor negative occurred younger patients (43 v 53 years). At time relapse, six additional had acquired amplification. The mean recurrence-free survival 24...