A5051384436- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Breast Implant and Reconstruction
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Proteoglycans and glycosaminoglycans research
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- Advances in Oncology and Radiotherapy
- Genomic variations and chromosomal abnormalities
- Gastrointestinal disorders and treatments
- Physics and Engineering Research Articles
- Gastrointestinal Tumor Research and Treatment
Mammazentrum Hamburg
2010-2023
Krankenhaus Jerusalem
2002-2023
Salem Hospital
2022
Breast Center
2012-2017
Women‘s Healthcare Group
2017
Agendia (Netherlands)
2017
Universität Hamburg
1989-2013
Kliniken Essen-Mitte
2011-2013
University Medical Center Hamburg-Eppendorf
1989-2013
Agaplesion Markus Hospital
2013
This phase III study compared docetaxel and doxorubicin in patients with metastatic breast cancer who had received previous alkylating agent-containing chemotherapy.Patients were randomized to receive an intravenous infusion of 100 mg/m(2) or 75 every 3 weeks for a maximum seven treatment cycles.A total 326 randomized, 165 161 docetaxel. Overall, produced significantly higher rate objective response than did (47.8% v 33.3%; P =.008). Docetaxel was also more active negative prognostic...
Assessment of prognostic markers in breast cancer independent the axillary lymph node status is major concern for application adjuvant treatment regimens. The current decision based mainly on status. Because improved screening methods, number and proportion patients with node-negative disease are increasing, which warrants a search reliable parameters. tumor suppressor gene expression appears to be especially suited as marker progress malignant cellular dedifferentiation.Tumor tissues 156...
BackgroundWe carried out a prospective clinical study to evaluate the impact of Recurrence Score (RS) on treatment decisions in early breast cancer (EBC).Patients and methodsA total 379 eligible women with estrogen receptor positive (ER+), HER2-negative EBC 0–3 lymph nodes were enrolled. Treatment recommendations, patients' decisional conflict, physicians' confidence before after knowledge RS actual data recorded.ResultsOf 366 assessable patients 244 node negative (N0) 122 (N+)....
Neoadjuvant systemic treatment (NST) elicits a pathologic complete response in 40%-70% of women with breast cancer. These patients may not need surgery as all local tumor has already been eradicated by NST. However, nonsurgical approaches, including imaging or vacuum-assisted biopsy (VAB), were able to accurately identify without residual cancer the axilla. We evaluated feasibility machine learning algorithm (intelligent VAB) exceptional responders NST.We trained, tested, and validated using...
Objective: We evaluated the ability of minimally invasive, image-guided vacuum-assisted biopsy (VAB) to reliably diagnose a pathologic complete response in breast (pCR-B). Summary Background Data: Neoadjuvant systemic treatment (NST) elicits up 80% women with cancer. In such cases, surgery, gold standard for confirming pCR-B, may be considered overtreatment. Methods: This multicenter, prospective trial enrolled 452 presenting initial stage 1-3 cancer all biological subtypes. Fifty-four...
Pathological morphological changes in tumor tissue enable collective cancer cell unjamming, a cellular motility transition. However, fundamental questions remain: Is unjamming essential for progression? Which different states can be found patients? Here, vital tracking patient-derived solid explants (N=16) reveals that of recognized by elongated and nucleus shape (CeNuS) low number density. These static variables serve as morphodynamic link to map the broad range morphologies associated...
Abstract Purpose: The predictive value of topoisomerase-IIα (topo-II) has been evaluated in advanced breast cancer patients randomly treated with single-agent doxorubicin or docetaxel. Experimental design: Primary tumor samples from enrolled a randomized, phase III clinical trial comparing (75 mg/m2 q3wks) docetaxel (100 were collected and topo-II status was by immunohistochemistry (clone KiS1). Results: Topo-II 108 samples, 55 (51%) the arm 53 (49%) arm. An increment 10% cells expressing is...
Journal Article Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern and fetal skin Get access P.H. Hoeger, Hoeger Departments of Dermatology Dr Peter H.Hoeger. E‐mail: hoeger@uke.uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar V. Schreiner, Schreiner Paul‐Gerson‐Unna Skin Research Center, Beiersdorf Inc., Hamburg, Germany I.A. Klaassen, Klaassen C.C. Enzmann, Enzmann K. Friedrichs, Friedrichs Obstetrics/Gynaecology,...
NY-CO-58/KIF2C has been identified as a tumor antigen by screening antibody responses in patients with colorectal cancer. However, expression had not consequently examined, and nothing was known about its ability to induce spontaneous T cell responses, which have suggested play role the development of We analyzed 5 cancer lines, samples adjacent healthy tissues from 176 epithelial cancers for RT-PCR Western Blot. 43 35 donors were evaluated ELISpot following stimulation 30mer peptides or...
Objective:The 21-gene assay (Oncotype DX Breast Cancer Test (Genomic Health Inc., Redwood City, CA)) is a well validated test that predicts the likelihood of adjuvant chemotherapy benefit and 10-year risk distant recurrence in patients with ER+, HER2− early-stage breast cancer. The aim this analysis was to evaluate cost-effectiveness using inform decisions Germany.Methods:A Markov model developed make long-term projections recurrence, survival, quality-adjusted life expectancy, direct costs...
The goal in breast conserving surgery (BCS) of ductal carcinoma situ (DCIS) is removal the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there no adequate procedures for intraoperative margin assessment DCIS. A multicenter, single arm study was conducted to evaluate benefit novel device (MarginProbe®) during BCS DCIS, associated reduction re-excisions and cosmetic outcome treated patients. We present results 42 patients enrolled 3 German...
Scalp cooling is a long known method to reduce chemotherapy-induced alopecia in cancer patients with solid tumors. Due progress this method, medical device enabling individual feedback-controlled temperature regulation was evaluated. Between June 2011 and December 2012, 83 breast were included. Evaluation focussed on the quantification of alopecia, satisfaction side effects scalp system (neo-) adjuvant chemotherapy regimens. Alopecia done by patient evaluation experts rating.Based hair loss...
Desmoid type fibromatoses has proven to be a diagnostic and therapeutic challenge, as they often appear primarily carcinoma of the breast with high recurrence risk.A digital archive search was performed for period from 2009 end 2018. Inclusion criteria consisted histological examination at least surgical specimen in reference pathology department second opinion diagnosis radiology department.A total 14 women 1 man underwent surgery on desmoid fibromatosis breast. The average patient age 49...