A5052434013- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Pregnancy and preeclampsia studies
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Breast Cancer Treatment Studies
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Birth, Development, and Health
- Intraperitoneal and Appendiceal Malignancies
- Reproductive Biology and Fertility
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- MRI in cancer diagnosis
Essen University Hospital
2016-2025
University of Duisburg-Essen
2016-2025
Klinik für Frauenheilkunde
2015-2024
Arbeitsgemeinschaft Gynäkologische Onkologie Studiengruppe
2004-2024
National Center for Tumor Diseases
2021-2023
West German Heart and Vascular Center Essen
2007-2023
St. Anna Hospital
2021
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2012-2020
Klinik und Poliklinik für Urologie
2015-2020
Qiagen (Germany)
2018-2019
Angiogenesis plays a role in the biology of ovarian cancer. We examined effect bevacizumab, vascular endothelial growth factor inhibitor, on survival women with this disease.
Most patients with advanced ovarian cancer develop recurrent disease. For those who recur at least 6 months after initial therapy, paclitaxel platinum has shown a modest survival advantage over without paclitaxel; however, many clinically relevant neurotoxicity, frequently resulting in treatment discontinuation. Thus, an alternative regimen significant neurotoxicity was evaluated by comparing gemcitabine plus carboplatin single-agent platinum-sensitive patients.Patients were randomly...
The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like which have been suggested to the active source metastatic spread primary tumors. Furthermore, these also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), allows them travel site metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples 39 during a follow-up palliative chemo-, antibody - or...
Systematic pelvic and paraaortic lymphadenectomy has been widely used in the surgical treatment of patients with advanced ovarian cancer, although supporting evidence from randomized clinical trials limited.
Objective : Polycystic ovary syndrome (PCOS) has been shown to cause a reduction in quality of life. This study examines the extent different PCOS symptoms on quality-of-life, psychosocial well-being and sexual satisfaction. Methods Complete metabolic, hormonal, clinical data were obtained from total 120 women with PCOS. Patients compared 50 healthy establish reductions quality-of-life emotional well-being. In addition, correlation between variables major features obesity (body mass index...
Pazopanib is an oral, multikinase inhibitor of vascular endothelial growth factor receptor (VEGFR) -1/-2/-3, platelet-derived (PDGFR) -α/-β, and c-Kit. Preclinical clinical studies support VEGFR PDGFR as targets for advanced ovarian cancer treatment. This study evaluated the role pazopanib maintenance therapy in patients with whose disease did not progress during first-line chemotherapy.Nine hundred forty histologically confirmed ovary, fallopian tube, or peritoneum, International Federation...
The presence of circulating tumor cells (CTC) in breast cancer might be associated with stem cell-like which have been suggested to the active source metastatic spread primary tumors. Furthermore, able disseminate and metastasize, CTC must perform epithelial-mesenchymal transition (EMT). We studied expression three EMT markers cell marker ALDH1 from 502 patients. Data were correlated disseminated (DTC) bone marrow (BM) clinicopathological data patients.A total 2 × 5 ml blood was analyzed for...
Insulin resistance (IR) and central obesity are common features of the polycystic ovary syndrome (PCOS). Vitamin D is thought to play a role in pathogenesis type 2 diabetes by affecting insulin metabolism. The aim our study was investigate effect 25-hydroxyvitamin (25-OH-VD) on metabolic parameters IR PCOS. In 120 untreated PCOS patients (median age 28 years) levels 25-OH-VD (radioimmunoassay method provided DiaSorin), calcium anorganic phosphate were measured. addition, endocrine variables...
Abstract Purpose: Malignant ascites in ovarian carcinoma patients is associated with poor prognosis and reduced quality of life. The trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) enhances the antitumor activity by redirecting T cells Fcγ receptor I/III–positive accessory to tumor. This multicenter phase I/II dose-escalating study investigated tolerability efficacy i.p. application cancer malignant containing epithelial cell adhesion molecule (EpCAM)–positive tumor cells....
Journal Article Antibodies Against the Human Papillomavirus Type 16 Early Proteins in Sera: Correlation of Anti-E7 Reactivity With Cervical Cancer Get access Ingrid Jochmus-Kudielka, Jochmus-Kudielka * Deutsches Krebsforschungszentrum, Im Neuenheimer FeldHeidelberg, Federal Republic Germany (FRG) *Ingrid M.D., Krebsforschungszentrum. Feld, 6900 Heidelberg, Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Achim Schneider, Schneider...
Abstract Introduction The role of circulating tumor cells (CTCs) in blood primary breast cancer patients is still under investigation. We evaluated the incidence CTCs blood, we correlation between and disseminated (DTCs) bone marrow (BM), characterized for expression HER2, estrogen receptor (ER) progesterone (PR). Methods Blood 431 with were analyzed EpCAM, MUC1 HER2 transcripts AdnaTest BreastCancer ™ (AdnaGen AG, Germany). Expression ER PR was assessed an additional RT-PCR. BM aspirates...
Background: The combination of carboplatin and paclitaxel is the standard care for treatment ovarian cancer, yet rates recurrence death remain high. We performed a prospective randomized phase III study to examine whether sequential administration topotecan can improve efficacy in first-line advanced epithelial cancer. Methods: A total 1308 patients with previously untreated cancer (International Federation Gynecology Obstetrics stages IIB–IV) were randomly assigned receive six cycles...
Despite the progress that has been achieved, long-term survival rates in patients with advanced ovarian cancer are still disappointing. One attempt to improve results could be addition of non-cross-resistant drugs platinum-paclitaxel combination regimens. Anthracyclines were among candidates for incorporation as a third drug into first-line regimens.We performed prospectively randomized phase III study comparing carboplatin-paclitaxel (TC; area under curve 5/175 mg/m2, respectively)...
Radical hysterectomy with pelvic lymphadenectomy represents the standard treatment for early-stage cervical cancer. Results from a recent randomized controlled trial demonstrate that minimally invasive surgery is inferior to laparotomy regards disease-free and overall survival.To investigate oncologic safety of robot-assisted cancer as compared laparotomy.Robot-assisted laparoscopic radical non-inferior in recurrence-free survival advantage fewer post-operative complications superior...
Identification of families at risk for ovarian cancer offers the opportunity to consider prophylactic surgery thus reducing mortality. So far, identification potentially affected in Germany was solely performed via family history and numbers members with breast or cancer. However, neither prevalence deleterious variants BRCA1/2 nor reliability as trigger genetic counselling has ever been evaluated.
Abstract BACKGROUND Platinum resistance constitutes one of the most recognized clinical challenges for ovarian cancer. Notably, detection primary tumor-based excision repair cross-complementation group 1 (ERCC1) protein by immunohistochemistry was recently shown to be inaccurate prediction platinum resistance. On basis previous finding that circulating tumor cells (CTC) in blood cancer patients are prognostically significant, and given our hypothesis negative prognostic impact CTC may arise...
Extracellular vesicles (EVs) have been discussed as a diagnostic tool for minimal residual disease (MRD) evaluation in breast cancer (BC) addition to the analysis of circulating tumor cells (CTCs). Therefore, we investigated EV levels surrogate markers monitoring and prediction prognosis primary, non-metastatic, locally advanced BC patients. EVs were enriched from blood samples patients before after neoadjuvant chemotherapy (NACT) healthy females. marker expression was performed sizes...
Abstract Expression of the non-classical human leukocyte antigen-G (HLA-G) promotes cancer progression in various malignancies including epithelial ovarian (EOC). As single nucleotide polymorphisms (SNPs) HLA-G 3′ untranslated region (UTR) regulate expression, we investigated 3′UTR haplotypes arranged by SNPs healthy controls (n = 75) and primary EOC patients 79) determined soluble (sHLA-G) levels. Results were related to clinical status outcome. Although haplotype frequencies similar...
5500 Background: So far, there is no level-1 evidence regarding the role of systematic pelvic and para-aortic lymphadenectomy (LNE) in patients with advanced ovarian cancer (AOC) macroscopic complete resection und clinically negative lymph nodes (LN). Therefore, surgical management LNE worldwide very heterogeneous. Methods: Prospective randomized trial including newly diagnosed AOC FIGO IIB-IV pre- intra-operatively clinical LN were to versus no-LNE. All centers had qualify skills before...