A5091811082- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Intraperitoneal and Appendiceal Malignancies
- Cancer Risks and Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Gynecological conditions and treatments
- Multiple and Secondary Primary Cancers
- Pregnancy and Medication Impact
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Surgical Simulation and Training
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Cancer Genomics and Diagnostics
- Minimally Invasive Surgical Techniques
Karolinska Institutet
2016-2025
Karolinska University Hospital
2016-2025
Medical University of Graz
2022
Gynecologic Oncology Group
2019-2022
Memorial Sloan Kettering Cancer Center
2022
Maastricht University Medical Centre
2021
Women's & Children's Health Research Institute
2021
Sheba Medical Center
2021
Institute of Primate Research
2004-2014
KU Leuven
2004-2009
Background:Recent genetic and morphologic studies have challenged the traditional view on pathogenesis of ovarian cancer; suggesting that cancer predominantly arises within fallopian tubes or uterus. We hypothesize surgical removal is associated with a reduced risk for cancer.
To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome, taking into account maternal characteristics and assisted reproductive technology.Population based cohort study.Singleton births registered Swedish medical birth register between 1995 2007.By linkage patient register, 3787 among a diagnosis syndrome 1,191,336 without such diagnosis.Risk (gestational diabetes, pre-eclampsia, preterm birth, stillbirth, neonatal death, low Apgar score (<7 at five minutes),...
Study aimsTo prospectively assess the diagnostic accuracy of a pelvic sentinel lymph node (SLN) algorithm in high-risk endometrial cancer (HREC).Patients and methodsConsecutive women with presumed FIGO stage I-II HREC underwent robotic surgery at two academic centres by five accredited surgeons. An anatomically based was adhered to, following cervical injection indocyanine green (ICG), reinjection tracer case non-display predefined lymphatic pathways. After removal SLNs, infrarenal...
BACKGROUNDEndometriosis, a common gynaecological disease, is characterized by local and systemic inflammation, which may cause infertility consequently, increased utilization of assisted reproduction technology (ART). We aimed to estimate the risk for preterm birth, small-for-gestational-age (SGA) stillbirth, Caesarean section, pre-eclampsia antepartal haemorrhage among women with previous diagnosis endometriosis compared no endometriosis.
Radical hysterectomy with pelvic lymphadenectomy represents the standard treatment for early-stage cervical cancer. Results from a recent randomized controlled trial demonstrate that minimally invasive surgery is inferior to laparotomy regards disease-free and overall survival.To investigate oncologic safety of robot-assisted cancer as compared laparotomy.Robot-assisted laparoscopic radical non-inferior in recurrence-free survival advantage fewer post-operative complications superior...
The aim of the study was to compare overall survival (OS) and disease-free (DFS) after open robotic radical hysterectomy for early-stage cervical cancer.This a nationwide population-based cohort on all women with cancer stage IA1-IB squamous, adenocarcinoma or adenosquamous histological subtypes, from January 2011 December 2017, whom performed. Swedish Quality Register Gynaecologic Cancer used identification. To ensure quality conformity data disclose patients not yet registered, hospital...
Importance The risks and benefits of thromboprophylaxis therapy after cancer surgery are debated. Studies that determine thrombosis risk with high accuracy needed. Objectives To evaluate 1-year venous thromboembolic events major how these vary over time. Design, Setting, Participants This register-based retrospective observational matched cohort study included data on the full population Sweden between 1998 2016. All patients who underwent for bladder, breast, colon or rectum, gynecologic...
Studies of women with ulcerative colitis (UC) during pregnancy have reported increased risks preterm delivery, growth restriction, and congenital malformation. However, the results are inconsistent due to inadequate study design limitations in sample size.We performed a population-based prevalence on 2637 primiparous UC hospital diagnosis prior delivery 868,942 no Denmark Sweden, 1994-2006. Logistic regression analysis was used estimate relative for moderately (32-36 weeks) very (before 32...
Introduction Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, poses barriers to comparison outcomes across institutions or clinical trial sites. Standardization technique quality assessment tools are critical conduct trials. By identifying mandatory prohibited steps sentinel (SLN) cancer, purpose this study was develop validate a competency tool for use assurance....
BACKGROUND: Inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8 and tumour necrosis factor-alpha (TNF-α), are important in the pathogenesis of endometriosis. We assessed efficacy anti-TNF monoclonal antibody (mAb, c5N), known to prevent induced endometriosis baboons, reducing established baboons. METHODS: This prospective, randomized, blinded, controlled study was conducted baboons at Institute Primate Research (IPR), Nairobi, Kenya. Endometriosis 18 adult female (Papio anubis)...
ObjectivesTumor cells release fragments of their DNA into the circulation, so called cell-free tumor (ctDNA) or liquid biopsy. Here, we analyze if human papillomavirus (ctHPV DNA) is detectable before, during and after treatment, in patients with cervical cancer pre-malignant lesions that may develop cancer, whether ctHPV levels were correlated to patient characteristics outcome. Furthermore, total load studied using cfAlbumin as a surrogate marker.Methods18 locally advanced CC (LACC), 15...
The objective was to assess the impact of robot-assisted radical hysterectomy (RRH) on surgical and oncologic outcome costs compared with open (ORH) at a tertiary referral center in Sweden.In this retrospective analysis all patients treated pelvic lymphadenectomy for early stage uterine cervical cancer during 2006-2015 were included (n = 304). divided into two groups, ORH 155) RRH 149). Patient characteristics, FIGO stage, histology, adjuvant therapy, operation time, length stay (LOS), lymph...
Background Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy. Primary Objective To compare disease-free survival between FIGO (2009) stage IA2 IB1 (≤2cm) cancer who underwent open versus (laparoscopic robotic) Study Hypothesis We hypothesize that has similar oncologic outcomes to those of the approach....
ObjectiveUltra-radical surgery to achieve complete resection in advanced epithelial ovarian cancer (EOC) has been widely accepted without strong supporting data. Our objective was assess overall survival after a structured shift an ultra-radical upfront surgical treatment algorithm and investigate changes the distribution of primary treatments this shift.Patients methodsIn population-based cohort study, all women with suspected EOC Stockholm-Gotland region Sweden reported Swedish Quality...
To examine the patterns of recurrence and how these are associated with survival in vulvar squamous cell carcinoma. We also explored impact surgical groin staging (SGS).