A5078795645- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Genetic factors in colorectal cancer
- Gynecological conditions and treatments
- DNA Repair Mechanisms
- Lymphatic System and Diseases
- Simulation-Based Education in Healthcare
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Urinary and Genital Oncology Studies
- Gastric Cancer Management and Outcomes
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
King Edward Memorial Hospital
2016-2025
The University of Western Australia
2016-2025
Women and Infants Research Foundation
2018-2024
Royal Women's Hospital
2024
QIMR Berghofer Medical Research Institute
2024
Australia New Zealand Gynaecological Oncology Group
2020-2022
Vancouver General Hospital
2020
University of British Columbia
2020
Chinese University of Hong Kong
2018-2019
University Cancer Center Hamburg
2018
<h3>Importance</h3> Standard treatment for endometrial cancer involves removal of the uterus, tubes, ovaries, and lymph nodes. Few randomized trials have compared disease-free survival outcomes surgical approaches. <h3>Objective</h3> To investigate whether total laparoscopic hysterectomy (TLH) is equivalent to abdominal (TAH) in women with treatment-naive cancer. <h3>Design, Setting, Participants</h3> The Laparoscopic Approach Cancer Endometrium (LACE) trial was a multinational, equivalence...
Intrauterine levonorgestrel (LNG-IUD) is used to treat patients with endometrial adenocarcinoma (EAC) and hyperplasia atypia (EHA) but limited evidence available on its effectiveness. The study determined the extent which LNG-IUD or without metformin (M) weight loss (WL) achieves a pathological complete response (pCR) in EAC EHA.This phase II randomized controlled clinical trial enrolled histologically confirmed, clinically stage 1 FIGO grade EHA; body mass index > 30 kg/m2; depth of...
Obesity is common in endometrial cancer and surgery for these patients challenging. We compared total laparoscopic hysterectomy (TLH) with abdominal (TAH) respect to feasibility (operating time, estimated blood loss, length of hospital stay, conversion laparotomy) safety (perioperative morbidity mortality) a retrospective analysis 78 morbidly obese cancer. Analysis based on the intention treat. The treat was TLH 47 it could be successfully completed 42 (89.4%). mean weight all 118.7 kg,...
Abstract Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, subset of patients has an unexpected dramatic and durable response to treatment. We sought identify clinical, pathological, molecular determinants exceptional survival in women high-grade serous (HGSC), disease associated the majority deaths. Experimental Design: evaluated histories 2,283 and, after applying stringent clinical pathological selection criteria, identified 96 HGSC that represented...
Introduction Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, poses barriers to comparison outcomes across institutions or clinical trial sites. Standardization technique quality assessment tools are critical conduct trials. By identifying mandatory prohibited steps sentinel (SLN) cancer, purpose this study was develop validate a competency tool for use assurance....
Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a recently described severe neurological disorder predominantly affecting young women, which presents with psychosis, memory deficits, seizures, and encephalopathy, often requiring prolonged hospitalization. The condition frequently associated an underlying neoplasm, most ovarian teratoma, in such cases appears to be para-neoplastic, immune-mediated encephalopathy. histologic features of the teratomas anti-NMDAR have seldom been...
To describe survival patterns in a nationally complete cohort of Australian women with epithelial ovarian cancer, by sociodemographic and clinical factors. All 1192 diagnosed invasive cancer 2005 were identified through state-based registries. We obtained detailed information from their medical records 2009 updated data 2012. Crude 3-year, 5-year 7-year rates; 3-year conditional survival; hazard ratios (HRs) for the association participant characteristics survival, multivariable Cox...
Our objective was to validate the prognostic role of chemotherapy response score (CRS), which has been proposed for measuring tumor neoadjuvant in patients with high-grade serous tubo-ovarian carcinoma, predicting progression-free survival (PFS) and overall (OS).A retrospective cohort study conducted advanced carcinoma diagnosed between January 1, 2010, December 31, 2014, treated chemotherapy. Treatment-related regression determined according 3-tier CRS, results were compared standard...
Abstract Background Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo‐ovarian high‐grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification overexpression with survival, but to date no large‐scale, histotype‐specific validation has been performed. The hypothesis was that high‐level of overexpression, as well combination the two, are linked shorter overall survival HGSC. Methods Within Ovarian Tumor Tissue...
To determine the frequency and distribution of Fallopian tube involvement in patients with ovarian metastases non-gynaecological origin. All tissue was processed for histological examination a consecutive series 31 The most common primary sites were appendix (n = 10) colon 7), stomach 6) breast 4). Twenty cases (65%) showed at least one type tubal spread. Mural (14 cases) but serosal, intra-vascular, intra-epithelial intra-lumenal spread also identified 12, 9, 8 11 respectively....