A5100347868- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Metabolomics and Mass Spectrometry Studies
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Intraperitoneal and Appendiceal Malignancies
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Minimally Invasive Surgical Techniques
Yonsei University
2016-2025
Gangnam Severance Hospital
2016-2025
Seoul St. Mary's Hospital
1996-2024
Daejeon St. Mary's Hospital
2021-2024
Catholic University of Korea
2004-2024
Korea Food Research Institute
2024
Sejong University
2023-2024
Korea Atomic Energy Research Institute
2024
Maria Fertility Hospital
2024
Korea Research Institute of Bioscience and Biotechnology
2001-2023
Although microRNAs have recently been recognized as riboregulators of gene expression, little is known about microRNA expression profiles in serous ovarian carcinoma. We assessed the and association between prognosis carcinoma.Twenty patients diagnosed with carcinoma eight treated for benign uterine disease December 2000 September 2003 were enrolled this study. The examined using DNA microarray Northern blot analyses.Several differentially expressed compared normal tissues, including miR-21,...
Development of new biomarkers for ovarian cancer is needed early detection and disease monitoring. Analyses involving complementary DNA (cDNA) microarray data can be used to identify up-regulated genes in cells, whose products may then further validated as potential biomarkers.To describe validation studies an gene known osteopontin, previously identified using a cDNA system.Experimental cross-sectional were conducted healthy human surface epithelial cell lines cultures, archival...
Pazopanib is an oral, multikinase inhibitor of vascular endothelial growth factor receptor (VEGFR) -1/-2/-3, platelet-derived (PDGFR) -α/-β, and c-Kit. Preclinical clinical studies support VEGFR PDGFR as targets for advanced ovarian cancer treatment. This study evaluated the role pazopanib maintenance therapy in patients with whose disease did not progress during first-line chemotherapy.Nine hundred forty histologically confirmed ovary, fallopian tube, or peritoneum, International Federation...
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, molecular mechanisms which just being uncovered. All kingdoms life produce aminoacyl-tRNA synthetases (ARSs). Thus far, non-translational roles ARSs have largely been reported eukaryotes. Here, we report that threonyl-tRNA synthetase (AmTARS) gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor modulate immune homeostasis. Secreted AmTARS triggers M2...
Adaptation of tumor cells to the host is a major cause cancer progression, failure therapy, and ultimately death. Immune selection drives this adaptation in human by enriching with stem cell-like (CSC-like) phenotype that makes them resistant CTL-mediated apoptosis; however, mechanisms mediate CSC maintenance proliferation are largely unknown. Here, we report immune evolution toward CSC-like arises through Akt signaling pathway via transcriptional induction Tcl1a Nanog. Furthermore, found...
Abstract The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, mechanism physiological significance by which modifications lead PTEN suppression remain unclear. Here we demonstrate that destabilization induced EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination degradation are dependent on MKRN1 E3 ligase. These processes require stabilization...
6002 Background: SOLO2 (ENGOT ov-21; NCT01874353) showed that maintenance therapy with the PARP inhibitor olaparib in pts platinum-sensitive relapsed ovarian cancer (PSROC) and a BRCA mutation (BRCAm) led to statistically significant improvement median progression-free survival (PFS) of 13.6 months vs placebo (hazard ratio [HR] 0.30). Time second progression or death significantly improved (Pujade-Lauraine et al Lancet Oncol 2017) quality-adjusted PFS benefit was seen (Friedlander 2018)...
Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. including OCT4 and SOX2 been found various solid tumors. Here, we investigate the expression clinical significance cervical cancer. To define expression, performed immunohistochemistry for on 305 normal epithelium samples, 289 intraepithelial neoplasia 161 cases compared data clinicopathologic factors, survival rates patients was higher than...
The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal transplantation, have been applied to alter the microbiome promote healthy ageing. Nevertheless, prolongation of health span aged mice by remodelling remains challenging.Here, we report changes in microbial communities their functions mouse models during ageing three procedures including co-housing, serum-injection parabiosis. Our results showed that...
Abstract Cancer immunotherapy has emerged as a promising cancer treatment. However, the presence of immune-refractory tumor cells limits its clinical success by blocking amplification anti-tumor immunity. Previously, we found that immune selection drives evolution tumors toward multi-modal resistant and stem-like phenotypes via transcription induction AKT co-activator TCL1A NANOG. Here, report crucial role HSP90A at crossroads between NANOG-TCL1A axis multi-aggressive properties...
Abstract Purpose: Early results from the phase II MEDIOLA study (NCT02734004) in germline BRCA1- and/or BRCA2-mutated (gBRCAm) platinum-sensitive relapsed ovarian cancer (PSROC) showed promising efficacy and safety with olaparib plus durvalumab. We report of durvalumab an expansion cohort women gBRCAm PSROC (gBRCAm doublet cohort) two cohorts non-gBRCAm PSROC, one which also received bevacizumab (non-gBRCAm triplet cohorts). Patients Methods: In this open-label, multicenter study, PARP...
Abstract Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents unmet clinical need. Therefore, future studies should provide evidence regarding the mechanisms potential targets that can overcome as well alleviate pain. Here, we show emergence cisplatin highly associated EGFR hyperactivation, hyperactivation arisen by a transcriptional increase in pain-generating channel, TRPV1, via NANOG....
The credible constraint of morally hazardous or opportunistic behavior can enhance efficiency. This idea is applied to an examination local government institutions identify how council‐manager constrains opportunism in economic development by substituting low‐power bureaucratic incentives for high‐power electoral incentives. A panel design isolates changes the use strategies instruments 516 cities. central argument presented here that Progressive ideology separation politics and...
A seven-year-old male elk (Cervus elaphus nelsoni) was euthanized and necropsied after having a 3-week history of body weight loss, emaciation, excessive salivation, teeth grinding, fever, anorexia, respiratory distress. The imported into Korea from Canada on March 9, 1997. Gross pathologic findings were restricted to diffuse fibrinous pneumonia. Microscopic lesions included mild neuronal vacuolation spongiform change in the neuropil selected brain stem nuclei generalized astrocytosis....
To determine whether osteopontin (OPN) is increased in patients with AS and to investigate its relationship inflammatory disease activity bone remodelling process.This cross-sectional study included 30 23 age- sex-matched healthy controls. We assessed clinical characteristics laboratory parameters including the ESR, CRP, lipid profiles, Bath index (BASDAI) radiographic (BASRI). evaluate metabolism, we tested ALP, OCN C-telopeptide of type I collagen (CTX-I). Plasma levels OPN, TNF-alpha IL-6...
Cyclin dependent kinase 1 (Cdk1) have previously reported correlation with cancer growth and a key regulator for cell cycle. Mostly, Cdk1's function of nucleus cycle is well known to be associated cancer, but cytoplasmic traits are not clearly identified, yet. We revealed that tissue microarray blocks epithelial ovarian (n = 249) showed increased level Cdk1 (p < 0.001), in 0.192) histologic type independently. On survival analysis, overexpression conferred significantly worse prognosis...
Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the data, mRNA and protein level of glucose transporter-1 (GLUT-1) examined. GLUT-1 had an EOC/normal cells ratio 5.51 based on microarray. Real-time PCR immunohistochemistry demonstrated that expression significantly increased EOC (p = .029 p < .001, respectively). On survival analysis, overexpression (HR 4.80, .027) lymph node metastases 8.35, .016) conferred...