A5028386044- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Polyamine Metabolism and Applications
- Microtubule and mitosis dynamics
Yonsei University
2016-2025
Pohang University of Science and Technology
2024
Korea Institute of Brain Science
2014-2023
Seoul National University
2022
Keimyung University
2022
Sungkyunkwan University
2022
Yeungnam University Medical Center
2017
Severance Hospital
2015
National Cancer Center
2008-2013
Dong-A University
2012
Because lung cancer is the leading cause of cancer-related death, new approaches for preventing and controlling disease are needed. Chemoprevention both feasible effective. We evaluated potential deguelin, a natural plant product, as chemopreventive agent investigated its mechanism action.The effects deguelin on proliferation apoptosis normal, premalignant, malignant human bronchial epithelial (HBE) cells were assessed by using MTT assay, flow cytometry-based TUNEL western blot analyses. The...
Human breast cancers include cancer stem cell populations as well nontumorigenic cells. Breast cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation has been associated with pathogenesis human diseases, including cancer. However, a role for miRNA in stemness drug resistance yet be identified. Members miR34 family reportedly tumor-suppressor various cancers. Our results confirm that...
Abstract Introduction C-C chemokine receptor type 7 (CCR7) plays an important role in chemotactic and metastatic responses various cancers, including breast cancer. In the present study, authors demonstrated that microRNA (miRNA) let-7a downregulates CCR7 expression directly influences migration invasion of cancer cells. Methods The CCR7, its ligand CCL21, was detected cell lines patient tissues. Synthetic inhibitor were transfected into MDA-MB-231 MCF-7 cells, respectively, proliferation,...
Abstract The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, mechanism physiological significance by which modifications lead PTEN suppression remain unclear. Here we demonstrate that destabilization induced EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination degradation are dependent on MKRN1 E3 ligase. These processes require stabilization...
// Maria Lee 1, 2, * , Hee Jung Kim 3, Sang Wun 3 Sun-Ae Park Kyung-Hee Chun 4 Nam Hoon Cho 5 Yong Song 1 Young Tae Department of Obstetrics and Gynecology, Seoul National University College Medicine, Seoul, Korea 2 Yonsei Graduate School, Institute Women's Life Medical Science, Biochemistry Molecular Biology, Pathology, These authors have contributed equally to this work Correspondence to: Kim, email: ytkchoi@yuhs.ac Keywords: HOTAIR, long non-coding RNA, invasion, prognosis, cervical...
Recently, the interest in natural products for treatment of cancer is increasing because they are pre-screened candidates. In present study, we demonstrate therapeutic effect celastrol, a triterpene extracted from root bark Chinese medicine on gastric cancer. The proliferation AGS and YCC-2 cells were most sensitively decreased six kinds cell lines after with celastrol. Celastrol inhibited migration increased G1 arrest cell-cycle populations both lines. celastrol significantly induced...
CD44 plays a role in the progression of tumors and is expressed cancer stem cells (CSCs). However, mechanisms underlying crosstalk with stemness genes CSC maintenance remains unclear. In this study, we demonstrated how cleaved intracellular domain (CD44ICD) activates factors such as Nanog, Sox2 Oct4, contributes to tumorigenesis breast cancer. We have found that overexpression CD44ICD increased mammosphere formation cells. Treatment γ-secretase inhibitor (GSI), which blocks cleavage CD44ICD,...
Galectin-3, a β-galactoside-binding lectin, is elevated in obesity and type 2 diabetes mellitus, metformin treatment reduces these galectin-3 levels. However, the role of adipogenesis remains controversial. We found that 17-month-old galectin-3-deficient (lgals3−/−) mice had decreased body size epididymal white adipose tissue (eWAT) without related inflammatory diseases when fed normal chow. Galectin-3 knockdown significantly reduced adipocyte differentiation 3T3-L1 cells also expression...
Until now, Hippo pathway–mediated nucleocytoplasmic translocation has been considered the primary mechanism by which yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) coactivators regulate cell proliferation differentiation via enhanced associate domain (TEAD)-mediated target gene expression. In this study, however, we found that TAZ, but not YAP, is associated Golgi apparatus in macrophages activated Toll-like receptor ligands during resolution phase...
Recurrence and drug resistance of breast cancer are still the main reasons for cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis lethality cancer. Molecular mechanisms underlying CSC maintenance unclear. In this study, we generated mammospheres derived from MDA-MB231 cells MCF7 to enrich CSCs performed DNA microarray analysis. We found that expression carboxy terminus HSP70-interacting protein (CHIP) E3 ubiquitin ligase was significantly downregulated...
One of the properties human breast cancer cells is stemness, which characterized by self-renewal capability and drug resistance. Protein kinase D1 (PRKD1) functions as a key regulator many cellular processes downregulated in invasive cells. In this study, we found that PRKD1 was upregulated MCF-7-ADR Additionally, discovered expression negatively regulated miR-34a binding to 3'-UTR. increased following performance tumorsphere formation assay We also reduction ectopic or siRNA treatment...
// Hyeok Gu Kang 1, 2 , Da-Hyun Kim Seok-Jun Yunhee Cho Junghyun Jung 3 Wonhee Jang Kyung-Hee Chun 1 Department of Biochemistry and Molecular Biology, Yonsei University College Medicine, Seoul, Republic Korea Brain 21 PLUS Project for Medical Science, University, Life Dongguk Correspondence to: Chun, email: khchun@yuhs.ac Keywords: galectin-3, cancer stem cells, Notch1, ovarian Received: February 23, 2016 Accepted: September 02, Published: 09, ABSTRACT Ovarian is the most lethal gynecologic...
Gastric cancer is the fifth most common worldwide with a poor survival rate. Therefore, it important to identify predictive and prognostic biomarkers of gastric cancer. Laminin subunit beta 1 (LAMB1) involved in attachment, migration, organization during development, its elevated expression has been associated several cancers. However, role mechanism LAMB1 remains unknown. Here, we determined that upregulated tissues contributes cell growth motility. Using public database, showed was...
Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through DNA microarray studies after galectin-3 silencing, we demonstrated here that plays a key role in up-regulating expressions of protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1) PAR-1 thereby promoting gastric
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, underlying molecular mechanisms remain largely unknown. In this study, we investigated effect possible mechanism on migration invasion B16F10, a metastatic melanoma cell line, which matrix metalloproteinase- 1 (MMP-1) were both found to be highly expressed. Knockdown with specific siRNA reduced invasion, was associated expression MMP-1. To further investigate mechanism, examined knockdown...
We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis.A link between MKRN1 ARF was examined null mouse embryonic fibroblasts (MEFs) human cancer cells silencing using small interfering RNA (siRNA) short hairpin (shRNA). Ubiquitination proteasomal degradation assays were used to assess p14ARF associated with MKRN1. expression levels analyzed...
// Seok-Jun Kim 1 , Jung-Ah Hwang 2 Jae Y. Ro 3 Yeon-Su Lee and Kyung-Hee Chun Department of Biochemistry & Molecular Biology, Yonsei University College Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic Korea. Cancer Genomics Branch, Division Fusion Technology, National Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, The Methodist Hospital, Pathology Genomic Weill Medical Cornell University, Houston, TX, USA. Correspondence: Chun, email: Keywords : Galectin-7, Gastric...