A5100444279- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Handwritten Text Recognition Techniques
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Endometriosis Research and Treatment
- Climate Change and Health Impacts
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Genetic Associations and Epidemiology
- Neural Networks and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Consumer Perception and Purchasing Behavior
- Lung Cancer Treatments and Mutations
- Education and Learning Interventions
- Food Quality and Safety Studies
- Uterine Myomas and Treatments
- Diverse Approaches in Healthcare and Education Studies
- Blood properties and coagulation
- Semiconductor materials and devices
- Diet and metabolism studies
- Educational Systems and Policies
- Natural product bioactivities and synthesis
Asan Medical Center
2010-2025
Ulsan College
2012-2025
University of Ulsan
2012-2025
Neurology, Inc
2025
Korea Food Research Institute
2010-2024
Seoul National University
2013-2024
Sejong University
2009-2024
Seoul National University Hospital
2008-2024
Samsung (South Korea)
2004-2024
Seoul National University Bundang Hospital
2007-2024
When expression of more than one gene is required in cells, bicistronic or multicistronic vectors have been used. Among various strategies employed to construct vectors, an internal ribosomal entry site (IRES) has widely Due the large size and difference levels between genes before after IRES, however, a new strategy was replace IRES. A self-cleaving 2A peptide could be good candidate IRES because its small high cleavage efficiency upstream downstream peptide. Despite advantages peptides,...
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged brain after stroke. In this study, however, we effect on acute cerebral and peripheral inflammation intracerebral haemorrhage (ICH). NSCs (H1 clone) from fetal human were injected intravenously (NSCs-iv, 5 million cells) or intracerebrally (NSCs-ic, 1 at 2 24 h collagenase-induced ICH in rat model. Only NSCs-iv-2 resulted fewer initial neurologic deteriorations reduced oedema formation,...
Although the effect of air pollution on various diseases has been extensively investigated, few studies have examined its depression.We investigated symptoms depression in an elderly population.We enrolled 537 participants study who regularly visited a community center for located Seoul, Korea. The Korean version Geriatric Depression Scale-Short Form (SGDS-K) was used to evaluate depressive symptomatology during 3-year follow-up study. We associated ambient pollutants with SGDS-K results...
Liver and serum metabolites of obese lean mice fed on high fat or normal diets were analyzed using ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry, gas chromatography-mass partial least-squares-discriminant analysis (PLS-DA). Obese groups clearly discriminated from each other PLS-DA score plot major contributing to the discrimination assigned as lipid (fatty acids, phosphatidylcholines (PCs), lysophosphatidylcholines (lysoPCs)), metabolism intermediates...
Uterine fibroids are hormone-responsive neoplasms that associated with heavy menstrual bleeding. Elagolix, an oral gonadotropin-releasing hormone antagonist resulting in rapid, reversible suppression of ovarian sex hormones, may reduce fibroid-associated
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
The paper introduces three extensions of the A* search algorithm which improve efficiency by relaxing admissibility condition. 1) employs an admissible heuristic function but invokes quicker termination conditions while still guaranteeing that cost solution found will not exceed optimal a factor greater than 1 + . 2) R¿* may employ functions occasionally violate condition, guarantees at risk missing opportunity for further reduction is most ¿. 3) R¿*,* speedup version R¿*, combining...
Genome-wide association studies have identified three chromosomal regions at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these associations in independent investigate heterogeneity within specific subgroups, we conducted a coordinated genotyping study International Lung Cancer Consortium based on that were not included previous genome-wide studies.Genotype data for single-nucleotide polymorphisms chromosomes 15q25 (rs16969968, rs8034191), 5p15...
Adaptation of tumor cells to the host is a major cause cancer progression, failure therapy, and ultimately death. Immune selection drives this adaptation in human by enriching with stem cell-like (CSC-like) phenotype that makes them resistant CTL-mediated apoptosis; however, mechanisms mediate CSC maintenance proliferation are largely unknown. Here, we report immune evolution toward CSC-like arises through Akt signaling pathway via transcriptional induction Tcl1a Nanog. Furthermore, found...
Bisphenol A (BPA) is a high-volume production chemical that has been suspected to have adverse health effects. Recent studies suggested cardiovascular diseases are associated with the BPA exposure. The aim of present study was investigate associations urinary heart rate variability and blood pressure. We recruited 560 noninstitutionalized elderly citizens from August 2008 2010 in Seoul. All participants were ≥60 years old. took medical examinations ≤5 times. Urinary concentration,...
While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined by histological type. In this study, we evaluated smoke-lung relationship type based on pooled data from 18 case–control in International Lung Cancer Consortium (ILCCO), including 2,504 cases 7,276 control who were never smokers 10,184 7,176 controls ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity,...
Background Insulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM). Recently, a few studies have demonstrated that phthalates could cause oxidative stress which would contribute development IR. Therefore, we evaluated whether exposure affects IR, involved in phthalates-IR pathway. Methods We recruited 560 elderly participants, obtained blood urine samples during repeated medical examinations. For determination phthalate...
The use of gamification in healthcare has been gaining popularity. This prospective, randomized, clinical trial was designed to evaluate whether the preoperative process—via virtual reality (VR) gaming that provides a vivid, immersive and realistic experience—could reduce anxiety children. Seventy children scheduled for elective surgery under general anesthesia were randomly divided into either control or group. Children group received conventional education regarding process, whereas those...
Previous studies have suggested that diabetes mellitus (DM) is an outcome of exposure to air pollution, and metabolic detoxification genes affect pollution-related outcomes.We evaluated associations between pollutants markers insulin resistance (IR), underlying mechanism type 2 DM, effect modification by GSTM1, GSTT1, GSTP1 genotypes among elderly participants in the Korean Elderly Environmental Panel (KEEP) study.We recruited 560 people ≥ 60 years age obtained blood samples from them up...
BACKGROUND Although the clinical efficacy of paclitaxel in treatment gastric carcinoma has not been clearly defined, recent reports have suggested a possible role upper gastrointestinal carcinomas vitro and vivo. In this study, authors evaluated toxicity combination chemotherapy that included paclitaxel, 5-fluorouracil (5-FU), cisplatin patients with advanced carcinoma. METHODS Forty-one metastatic disease, unresectable or relapsed disease were treated following regimen, administered every...
In Brief BACKGROUND: Postoperative sore throat and hoarseness are common complications after tracheal intubation, particularly using a double-lumen endobronchial tube (DLT). We conducted prospective, randomized, double-blind, placebo-controlled study to evaluate the efficacy of dexamethasone for reducing incidence severity postoperative hoarseness. METHODS: One hundred sixty-six patients (aged 18–75 yr) scheduled thoracic surgery with DLT were enrolled. Before induction general anesthesia,...