A5035139239- Air Quality and Health Impacts
- Energy and Environment Impacts
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Cancer Risks and Factors
- Hidradenitis Suppurativa and Treatments
- Telomeres, Telomerase, and Senescence
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Health, Environment, Cognitive Aging
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Smoking Behavior and Cessation
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Global Cancer Incidence and Screening
- Multiple Myeloma Research and Treatments
- Genetic Associations and Epidemiology
- Occupational and environmental lung diseases
Albert Einstein College of Medicine
2016-2025
The Bronx Defenders
2018-2023
United States Department of Health and Human Services
2009-2023
National Cancer Institute
2008-2023
Division of Cancer Epidemiology and Genetics
2010-2023
Cancer Genetics (United States)
2015-2023
National Institutes of Health
2009-2023
Yeshiva University
2014-2023
Montefiore Medical Center
2020-2021
United States Census Bureau
2020
In the Comparative Risk Assessment (CRA) done as part of Global Burden Disease project (GBD-2010), global and regional burdens household air pollution (HAP) due to use solid cookfuels, were estimated along with 60+ other risk factors. This article describes how HAP CRA was framed; exposures modeled; diseases judged have sufficient evidence for inclusion; meta-analyses exposure-response modeling estimate relative risks. We explore relationships factors: ambient pollution, smoking, secondhand...
Lung cancer is considered an age-associated disease, whose progression in part due to accumulation of genomic instability as well age-related decline system integrity and function. Thus even among individuals exposed high levels genotoxic carcinogens, such those found cigarette smoke, lung susceptibility may vary a function individual differences the rate biological aging. We recently developed highly accurate candidate biomarker aging based on DNA methylation (DNAm) levels, which prove...
Bacteria influence site‐specific disease etiology and the host's ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs). Lung cancer in Xuanwei, China has been attributed PAH‐rich household air pollution from burning coal. This study seeks explore role of lung microbiota among never smoking Xuanwei women how coal may these associations. DNA sputum buccal samples cases ( n = 8, duplicate) controls two villages was extracted using a multi‐step enzymatic physical...
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
During the bloodstage of malaria infection, parasite internalizes and degrades massive amounts hemoglobin from host red blood cell. Using serial thin-section electron microscopy three-dimensional reconstruction, we demonstrate four independent, but partially overlapping, hemoglobin-uptake processes distinguishable temporally, morphologically, pharmacologically. Early ring-stage parasites undergo a profound morphological transformation in which they fold, like cup, onto themselves so doing...
Mitochondria are eukaryotic organelles responsible for energy production. Mitochondrial DNA (mtDNA) lack introns and protective histones, have limited repair capacity compensate damage by increasing the number of mtDNA copies. As a consequence, mitochondria more susceptible to reactive oxygen species, an important determinant cancer risk, it is hypothesized that increased copy may be associated with carcinogenesis. We assessed association lung risk in 227 prospectively collected cases...
The combustion of biomass and coal is the dominant source household air pollution (HAP) in China, contributes significantly to total burden disease Chinese population. To characterize HAP exposure related solid fuel use ventilation patterns, an assessment study 163 nonsmoking female heads households enrolled from 30 villages was conducted Xuanwei Fuyuan, two neighboring rural counties with high incidence lung cancer due burning smoky (a bituminous coal, which health evaluations usually...
BackgroundDomestic fuel combustion from cooking and heating is an important public health issue because roughly 3 billion people are exposed worldwide. Recently, the International Agency for Research on Cancer classified indoor emissions household coal as a human carcinogen (group 1) biomass (primarily wood) probable 2A).ObjectivesWe pooled seven studies Lung Consortium (5,105 cases 6,535 controls) to provide further epidemiological evaluation of association between in-home solid-fuel use,...
We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Screening Trial, conducted among men women United States, previously published data Alpha-Tocopherol, Beta-Carotene Prevention (ATBC) Trial male smokers Finland, Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The population included 847 cases controls matched by study, age,...
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk adenocarcinoma lung. The telomerase gene TERT is a reverse transcriptase critical for telomere replication stabilization by controlling length. We previously found longer length measured peripheral white blood cell DNA increased prospective cohort smoking males...
Objective To prospectively investigate whether diversity in oral microbiota is associated with risk of lung cancer among never-smokers. Design and setting A nested case–control study within two prospective cohort studies, the Shanghai Women’s Health Study (n=74 941) Men’s (n=61 480). Participants Lifetime never-smokers who had no at baseline. Cases were subjects diagnosed incident (n=114) matched 1:1 controls on sex, age (≤2 years), date (≤30 days) time (morning/afternoon) sample collection,...
Indoor gas stove use for cooking is associated with an increased risk of current asthma among children and prevalent in 35% households the United States (US). The population-level implications are largely unrecognized. We quantified population attributable fraction (PAF) childhood US. Effect sizes previously reported by meta-analyses (Odds Ratio = 1.34, 95% Confidence Interval (CI) 1.12–1.57) were utilized PAF estimations. proportion (<18 years old) exposed to stoves was obtained from...
Telomere length plays an important role in the maintenance of chromosomal stability and tumorigenesis. We hypothesized that telomere peripheral WBC DNA obtained from healthy individuals would be a predictor future risk developing non-Hodgkin lymphoma.Using new assay to measure relative length, monochrome multiplex quantitative PCR, which strongly correlates with measured by Southern blot (Spearman r = 0.91, P < 0.0001) has high precision (coefficient variation 7%), we compared 107 incident...
Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies developing and rural countries. We report the association of conditions, fuel use, oil a developed urban population prospective cohort women Shanghai. A total 71,320 never smoking were followed from 1996 through 2009 429 incident cases identified. Questionnaires collected information on household living practices for three most recent residences utilization oil,...
Recent evidence from several relatively small nested case‐control studies in prospective cohorts shows an association between longer telomere length measured phenotypically peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere‐length associated genetic variants large study 5,457 never‐smoking female Asian cases 4,493 controls using data previously reported genome‐wide study. Using group...