A5059201727- Lung Cancer Treatments and Mutations
- Glutathione Transferases and Polymorphisms
- Electronic Packaging and Soldering Technologies
- DNA Repair Mechanisms
- Psoriasis: Treatment and Pathogenesis
- 3D IC and TSV technologies
- Estrogen and related hormone effects
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Hepatitis B Virus Studies
- Lung Cancer Research Studies
- Mycobacterium research and diagnosis
- Carcinogens and Genotoxicity Assessment
- Dermatology and Skin Diseases
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Health Systems, Economic Evaluations, Quality of Life
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Melanoma and MAPK Pathways
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
South China Normal University
2025
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2023-2024
National Clinical Research Center for Digestive Diseases
2023-2024
National Taiwan University
2010-2023
National Taiwan University Hospital
2010-2023
Institute of Biomedical Sciences, Academia Sinica
2023
Genomics Research Center, Academia Sinica
2012-2023
Second Affiliated Hospital of Zhejiang University
2021
Northwest A&F University
2019
Antituberculosis drug-induced hepatitis is one of the most prevalent liver injuries. Isoniazid major drug incriminated in this hepatotoxicity. mainly metabolized to hepatotoxic intermediates by N -acetyltransferase (NAT). However, association polymorphic NAT acetylator status and antituberculosis debatable. To determine whether a risk factor for hepatitis, we genotyped NAT2 224 incident tuberculosis patients who received treatment. was diagnosed based on positive isoniazid rechallenge test...
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
To determine the prevalence of joint and nail symptoms, impact these symptoms on health-related quality life (HR-QoL), effects etanercept them in patients with moderate-to-severe plaque psoriasis.In CRYSTEL, psoriasis received continuously (n = 357) or as paused therapy 363) for 54 weeks. In post hoc analyses, baseline characteristics after-treatment changes were evaluated pain psoriasis, pooling across treatment groups. Assessments symptom severity HR-QoL included Subject Global Assessment...
Adenocarcinoma is the most dominant type of lung cancer in never-smoker patients. The risk alleles from genome-wide association studies have small odds ratios and unclear biologic roles. Here we taken an approach featuring suitable medical actionability to identify with low population frequency but high disease-causing potential.Whole-genome sequencing was performed for a family unusually density adenocarcinoma available DNA affected mother, four daughters, one nonaffected son. Candidate...
This study evaluated whether the codon 72 p53 polymorphism was related to hepatocellular carcinoma (HCC). Genotypes of were determined in 80 incident cases HCC and 328 controls nested a cohort 4,841 male chronic hepatitis B carriers. No overall increase risk with Pro variant allele apparent. However, there synergistic effects on development for liver disease family history first–degree relatives. Compared subjects without disease, associated among those only threefold. Subjects both at an...
A variety of environmental factors were identified to be associated with the risk esophageal cancer. The variation in capacity DNA repair might influence chemical-associated carcinogenesis. We hypothesized that polymorphic XRCC1 genes modify cancer susceptibility esophagus. To investigate effect genetic polymorphisms on codons 194, 280 and 399, we evaluated data from 105 patients squamous cell carcinoma 264 healthy controls, matching age (±3 years), gender ethnicity. distribution 3 genotypes...
Chronic infection with hepatitis B virus (HBV) causes DNA damage. An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated In a case–control study of 577 HBV surface antigen carriers hepatocellular carcinoma (HCC) and 389 carrier control subjects, we investigated association between this risk HCC assessed whether varied glutathione S-transferase (GST) status; GSTs are involved carcinogen metabolism. All statistical tests were two-sided. The...
Background Hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) mainly by causing chronic necroinflammatory hepatic disease.We investigated the mechanisms underlying inflammatory hepatocarcinogenesis examining whether genetic variations in cytokines, antioxidant enzymes, and DNA repair genes affect HCC risk. MethodsWe analyzed 10 polymorphisms for interleukin-1b (IL-1B), interleukin-1-receptor antagonist (IL-1RN), tumor necrosis factor-a (TNF-A), glutathione S-transferase, XRCC1,...
BACKGROUND The role of family history lung cancer (LCFH) in screening using low-dose computed tomography (LDCT) has not been prospectively investigated and with long-term follow-up. METHODS A multicenter prospective study up to three rounds annual LDCT was conducted determine the detection rate LC asymptomatic first or second-degree relatives LCFH. RESULTS From 2007 2011, there were 1,102 participants enrolled, including 805 297 from simplex (SF) multiplex families (MF), respectively (54.2%...
The application of rubber powder in modified asphalt has garnered significant attention the field road engineering and materials science. This paper discusses advantages methods pretreating process application, including thermal mechanical method, chemical microwave radiation supercritical fluid induction, biological method. By breaking sulfur cross-linking bonds powder, increasing its surface activity, improving dispersibility reactivity, shows improvements high-temperature stability,...
Large Language Models (LLMs) are widely applied in decision making, but their deployment is threatened by jailbreak attacks, where adversarial users manipulate model behavior to bypass safety measures. Existing defense mechanisms, such as fine-tuning and editing, either require extensive parameter modifications or lack precision, leading performance degradation on general tasks, which unsuitable post-deployment alignment. To address these challenges, we propose DELMAN (Dynamic Editing for...
The interaction of genetic and environmental factors can determine an individual's susceptibility to various cancers. We present a hospital-based case-control study, which included 90 patients esophageal squamous-cell carcinoma (ESCC) 254 healthy people in Taiwan, investigate the effects polymorphisms p53, GSTP1 NAT2 on risk ESCC. Polymorphisms were determined by PCR-RFLP. codon 72 p53 Pro allele was more frequently found ESCC [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.04–3.35 for...
Abstract Background Impaired sleep in patients with moderate‐to‐severe psoriasis and improvement on therapy has not been widely studied. Objective Quantify baseline aspects of receiving etanercept (ETN) when allowed concomitant topical medications ( PRISTINE study). Methods Patients were randomized to 50 mg ETN once weekly QW / ) or twice (BIW/QW) for weeks 1–12, followed by 13–24; a broad range therapies permitted during 13–24. Sleep impairment was measured the Medical Outcomes Study MOS...
Chemotherapeutic options against Mycobacterium abscessus infections are very limited. Bedaquiline, a new antituberculosis (anti-TB) drug, is effective for the treatment of multidrug-resistant TB. However, few data available on bedaquiline M. infections. In this study, we determined profile in vitro susceptibility clinical isolates to and investigated potential molecular mechanisms decreased susceptibility. A total 197 were collected from sputum bronchoalveolar fluid patients with lung...
This study aimed to determine the antibiotic susceptibility and resistance related genotypes of Mycobacterium abscessus. One hundred sixty-two clinical isolates were collected. Genomic data obtained by whole genome sequencing. Single nucleotide polymorphism (SNP) analysis was conducted using NCBI GenBank database BLAST algorithm. The following genes interest: erm(41), rrl rrs. Erm(41) further divided into 3 sequevars: erm(41)C28, erm(41)T28, M type [erm(41) with deletions in nucleotides 64...
// Sung-Hsin Kuo 1, 5, 6, 7 , Shi-Yi Yang 8 San-Lin You 9, 10 Huang-Chun Lien 2 Ching-Hung Lin 6 Po-Han 3 Chiun-Sheng Huang 4 1 Department of Oncology, National Taiwan University Hospital and College Medicine, Taipei, Pathology, Medical Genetics, Surgery, 5 Graduate Institute Cancer Research Center, Epidemiology, Public Health, University, 9 School Fu-Jen Catholic New Big Data Correspondence to: Huang, email: huangcs@ntu.edu.tw Keywords: genetic polymorphism, GWAS, breast cancer, prognostic...
Cardiometabolic, clinical and quality-of-life (QoL) measures were assessed before after etanercept treatment in patients who had moderate-to-severe plaque psoriasis with without psoriatic arthritis (PsA) the PRISTINE trial. Adult randomized to receive 50 mg once weekly or twice double-blind for 12 weeks; all subsequently received open-label through week 24. Metabolic syndrome was identified 44 41% of PsA, elevated blood pressure 73 56% (p < 0.05) diabetes 21 9% 0.01), respectively....