A5072593323- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Liver physiology and pathology
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Diabetes Treatment and Management
- Galectins and Cancer Biology
- Renal Transplantation Outcomes and Treatments
National Taiwan University Hospital
2016-2025
National Taiwan University
2016-2025
Chinese University of Hong Kong
2024
Chang Gung Memorial Hospital
2005-2024
Anhui Agricultural University
2024
National Yunlin University of Science and Technology
2024
Mackay Memorial Hospital
2006-2023
Taipei Institute of Pathology
2007-2023
Peking University First Hospital
2023
Far Eastern Memorial Hospital
2023
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding natural history HBV potential for therapy resultant disease is continuously improving. New data become available since previous APASL guidelines management were published 2012. The objective this manuscript to update recommendations optimal infection. 2015 developed by a panel Asian experts chosen APASL. clinical practice are based on evidence...
BackgroundHepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and identify predictors for vaccinated birth cohorts.
Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles viral load and HBV genotype remain unclear.From 1988 through 1992, baseline blood samples were collected from 4841 Taiwanese men who carriers but had not diagnosed HCC. We used real-time polymerase chain reaction assays plasma DNA to quantify levels (a measure load) determine genotypes for 154 case patients HCC during 14 years follow-up 316 control subjects....
This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) C (HCV) serostatus, explored the possible joint influence of obesity/diabetes HBV/HCV infections on risk HCC.A total 23,820 residents in Taiwan were recruited followed up for 14 years. All analyses surface antigen (HBsAg) antibody to HCV (anti-HCV) at enrollment, 218 subjects positive both seromarkers excluded....
Background & AimsPatients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients lower levels of surface antigen (HBsAg) higher chances losing HBsAg than those levels. However, little is known about whether increase HCC.MethodsWe followed 2688 Taiwanese HBsAg-positive patients without evidence cirrhosis mean time period 14.7 years. In addition to the factors HCC, we investigated association between and development HCC.ResultsOf...
Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antiviral therapy is a major barrier to eradication chronic (CHB). Curing CHB will require novel strategies for specific disruption cccDNA. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system newly developed tool site-specific cleavage targets directed by synthetic guide RNA (gRNA) base-paired the target sequence. To examine whether this can cleave HBV genomes, we...
Chronic hepatitis B patients with high viral loads are at increased risk of cirrhosis and hepatocellular carcinoma (HCC). In low loads, higher surface antigen (HBsAg) levels have been shown to predict HCC development. However, little is known about the difference in for other virus (HBV)-related adverse outcomes varying HBsAg levels. A total 1,068 Taiwanese e (HBeAg)-negative HBV carriers serum DNA level <2,000 IU/mL baseline were followed a mean duration 13.0 years. Patients categorized...
The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization HBV prevents their developing HCC as adults. also searched for strategies to maximize the cancer-preventive effects.We collected data from 2 Taiwan registry systems on 1509 patients (6-26 years old) diagnosed 1983 through 2011. Data history and prenatal maternal levels antigens all...
This study assessed the effects of glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide relative to selective GLP-1 agonist semaglutide on liver fat content (LFC) in patients with non-alcoholic fatty disease (NAFLD).This was a phase IIa, randomized, active-comparator-controlled, parallel-group, open-label study. A magnetic resonance imaging-estimated proton density fraction assessment performed determine LFC at screening and Week 24. Participants an ≥10% were...
ABSTRACT Background Data regarding the risk of incident type 2 diabetes (T2D) and prediabetes among patients with hepatitis C virus (HCV) achieving direct‐acting antivirals (DAAs)‐induced sustained virologic response (SVR 12 ) remains limited. Methods A total 1079 patients, including 589 normoglycemia 490 prediabetes, who underwent biannual fasting glucose glycosylated haemoglobin (HbA1c) assessment for a median post‐SVR follow‐up 5.5 years, were enrolled. We reported crude (cIRs)...
Limited data exists regarding the long-term serum ferritin dynamics following sustained virologic response (SVR12) and factors associated with trends in changes among patients undergoing treatment for hepatitis C virus (HCV). Serum levels were assessed biannually 1538 participants direct-acting antivirals (DAAs) or peginterferon plus ribavirin (PR) a median of follow-up 5.0 years after off-treatment week 12. We compared differences time-dependent slope coefficients interest using generalized...
Background & Aims: The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear were thus investigated this study. Methods: sequences the region BCP (A1762T, G1764A) PC (G1896A) mutations determined 46 HBV carriers (CC) 106 age-matched with different liver diseases, including 38 (CH), 18 cirrhosis (LC), 50 hepatocellular carcinoma (HCC). Results: A higher prevalence deletion...
Mammalian eggs are surrounded by a thick extracellular coat, the zona pellucida, that plays important roles during early development. The mouse egg pellucida is constructed of three glycoproteins, called mZP1, mZP2, and mZP3. gene encoding mZP3 expressed only growing oocytes 2- to 3-week period oogenesis. Here, was disrupted targeted mutagenesis using homologous recombination in embryonic stem cells. Viable female mice homozygous for mutated allele (mZP3-/-) were obtained. These...
Loss of hepatitis B surface antigen (HBsAg) usually indicates that virus (HBV) infection has been cured. However, little is known about factors predicting HBsAg loss in patients who spontaneously clear e (HBeAg).We studied 390 Taiwanese HBeAg-positive with chronic had cleared HBeAg (seroconversion) during follow-up. Serum levels HBV DNA and were determined 1 year after seroconversion, their relationships subsequent investigated.In a mean follow-up 7.4 years, the average annual rate was...
Background. Comparable sustained virologic response (SVR) rates have been documented between Asian patients who received 24 weeks of pegylated interferon (IFN) plus ribavirin and white 48 combination therapy for hepatitis C virus genotype 1 (HCV-1) infection. Whether a 48-week course shows better SVR rate than 24-week such among with HCV-1 infection has not confirmed in multicenter, randomized studies. Methods. In this trial, 308 treatment-naive HCV-1-infected were randomly assigned to...
Several hepatitis B viral factors correlate with the progression of chronic liver disease. However, independent and interactive effects each known factor on development hepatocellular carcinoma (HCC) remain largely unknown.In a cross-sectional, retrospective, hospital-based setting, we comprehensively compared in 160 virus (HBV) carriers 200 patients HCC, to clarify joint effect factor.In univariate analysis, statistically significant odds ratios (ORs) were obtained for male sex (P < .001),...