A5110548360- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Genetic factors in colorectal cancer
National Defense Medical Center
2016-2025
Tri-Service General Hospital
2016-2025
Weatherford College
2020
Far Eastern Memorial Hospital
2015
Zero to Three
2012
China Medical University Hospital
2012
China Medical University
2012
Central Taiwan University of Science and Technology
2009
National Taiwan University of Science and Technology
2009
Shin Kong WHS Memorial Hospital
2009
ABSTRACT Background Data regarding the risk of incident type 2 diabetes (T2D) and prediabetes among patients with hepatitis C virus (HCV) achieving direct‐acting antivirals (DAAs)‐induced sustained virologic response (SVR 12 ) remains limited. Methods A total 1079 patients, including 589 normoglycemia 490 prediabetes, who underwent biannual fasting glucose glycosylated haemoglobin (HbA1c) assessment for a median post‐SVR follow‐up 5.5 years, were enrolled. We reported crude (cIRs)...
Oncogenic activation of the Wnt/β-catenin signaling pathway is common in hepatocellular carcinoma (HCC). Our recent studies have demonstrated that SRY (sex determining region Y)-box 1 (SOX1) and secreted frizzled-related proteins are concomitantly promoter-hypermethylated, this might lead to abnormal Wnt HCC. SOX1 encodes a transcription factor involved regulation embryonic development cell fate determination. However, expression functional role HCC remains unclear. In study, we confirmed...
The secreted frizzled-related protein 1 gene (SFRP1) encodes a Wnt/beta-catenin signaling antagonist and frequently is inactivated by promoter methylation in many tumors. However, the role of SFRP1 hepatocellular carcinoma (HCC) not clear. Therefore, authors investigated whether common HCC it may influence expression.Four cell lines, 54 HCCs, 42 cirrhotic livers, 21 livers with chronic hepatitis, 15 normal control tissues were analyzed for 1) using methylation-specific polymerase chain...
Abstract Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). The secreted frizzled‐related proteins (SFRPs) function as negative regulators Wnt and have important implications for carcinogenesis. Promoter hypermethylation SFRP genes human cancers. However, role SFRPs HCC not clear. Recently, we shown that SFRP1 frequently downregulated through promoter hypermethylation. To confirm extend these findings, methylation status other members,...
Human malignant glioma cells are characterized by local invasion. In the present study, we investigated role of osteopontin (OPN) in invasiveness human isolated from grade IV tumors. We found that expression levels OPN these cell lines paralleled matrix metalloproteinase-2 (MMP-2) and potential. When U87MG (with a high-OPN level) were stably transformed with specific small hairpin RNA to knock down expression, MMP-2 secretion, invasiveness, tumor growth implanted brains dramatically reduced....
Objective Data regarding the real-world effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) with or without low-dose ribavirin (RBV) in patients chronic hepatitis C virus (HCV) infection severe renal impairment (RI) are limited. We evaluated performance SOF/VEL RBV HCV-infected kidney disease stage 4 5. Design 191 compensated (n=181) decompensated (n=10) liver diseases receiving (400/100 mg/day) alone (200 for 12 weeks were retrospectively recruited at 15 academic centres Taiwan....
Background: Aberrant DNA methylation is associated with the development of hepatocellular carcinoma (HCC), suggesting that gene could be a potential biomarker for detection HCC. The aim this study to identify biomarkers in
Background Hepatitis C virus (HCV) has been reported to regulate cellular microRNAs. The HCV core protein is considered be a potential oncoprotein in HCV-related hepatocellular carcinoma, but core-modulated microRNAs are unknown. regulates p21Waf1/Cip1 expression. However, the mechanism of core-associated regulation remains further clarified. Therefore, we attempted determine whether play an important role regulating expression human hepatoma cells. Methods Cellular microRNA profiling was...
The association of metabolic syndrome (MetS) components with elevated serum alanine aminotransferase (ALT) levels, a marker hepatic injury, may differ between men and women. However, the sex-specific in military young population which has low prevalence MetS was unclear. We conducted cross-sectional examination 6738 766 women, aged 18–50 years, from cardiorespiratory fitness study armed forces (CHIEF) eastern Taiwan. were defined according to updated International Diabetes Federation (IDF)...
Abstract DNA methylation is important in cancer development and a promising biomarker for detection. An epigenomic approach used our previous work showed that LMX‐1A methylation‐silenced cervical cancer. , LIM‐homeobox gene, known to participate developmental events; however, there are at present no data on the role of cancers. In this study, we characterized function transcription factor by examining cell lines, animal models human neoplastic tissues, found over‐expression does not affect...