Anna Ludovica Fracanzani
A5024750114- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Iron Metabolism and Disorders
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Folate and B Vitamins Research
- Hemoglobinopathies and Related Disorders
- Cardiovascular Disease and Adiposity
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Trace Elements in Health
- Porphyrin Metabolism and Disorders
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Metabolism and Genetic Disorders
- Liver Diseases and Immunity
- Lipoproteins and Cardiovascular Health
- Organ Transplantation Techniques and Outcomes
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Milan
2015-2024
Ospedale Maggiore
2009-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2023
Lombardia Informatica (Italy)
2023
Universitätsklinikum Knappschaftskrankenhaus Bochum
2022
United States University
2022
University of Michigan
2022
Michigan United
2022
Madrigal Pharmaceuticals (United States)
2022
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Abstract It is uncertain whether patients with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder should undergo biopsy. We reviewed the histological data of 458 Italian NAFLD in whom biopsy was indicated by altered enzymes (395 cases, 86%), or persistently elevated ferritin long-lasting severe steatosis (63 cases). Factors associated steatohepatitis (NASH) fibrosis ≥ 2 were identified multivariate analysis. Patients ALT significantly older, had...
Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease (NAFLD), and rs738409 C→G polymorphism of PNPLA3/adiponutrin, encoding for isoleucine-to-methionine substitution at residue 148 (I148M) protein variant, has recently been recognized as determinant fat content. However, effect on severity fibrosis patients with NAFLD is still unknown. In this study, we considered 253 Italian patients, 179 healthy controls, 71 family trios an affected child NAFLD....
Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic steatohepatitis (NASH) may progress to fibrosis and promote atherosclerosis. Carriers the TM6SF2 E167K variant have fatty liver as result reduced secretion very-low-density lipoproteins (VLDLs). As result, they lower circulating lipids risk myocardial infarction. In this study, we aimed assess whether affects damage cardiovascular outcomes in subjects at NASH. Liver was evaluated 1,201 patients who...
•Genetic predisposition to liver fat accumulation predisposes cirrhosis and HCC.•Hepatic promotes carcinogenesis, partly via fibrosis.•Polygenic risk scores may improve HCC stratification during dysmetabolism. Background & AimsHepatocellular carcinoma (HCC) in individuals with dysmetabolism is a major unmet need. Genetic contributes non-alcoholic fatty disease (NAFLD). We aimed exploit robust polygenic (PRS) that can be evaluated the clinic gain insight into causal relationship between NAFLD...
Abstract Steatosis has been reported to negatively influence the natural history of chronic hepatitis C (CHC), but controversy remains over its causal role due confounding effect adiposity, insulin resistance, and diabetes. The rs738409 C>G patatin-like phospholipase domain-containing 3 ( PNPLA3 ) single nucleotide polymorphism (SNP), encoding for I148M protein variant, influences liver fat without affecting resistance body composition. aim this study was evaluate CG genotype on fibrosis...
Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, allele was associated with NAFLD-HCC (OR 1.65, 1.08-2.55; n = 765), particularly those without advanced fibrosis (p < 0.001). risk linked 3'-UTR variation MBOAT7 and reduced expression patients...
Objective The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis Caucasian with NAFLD. Design study cohort comprises 1339 biopsy-proven NAFLD from four countries (Italy, UK, Spain Australia), stratified into non-lean (body mass index (BMI) </≥25 kg/m 2 ). Liver/non-liver-related events survival free transplantation were recorded during the...
This study assessed the effects of glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide relative to selective GLP-1 agonist semaglutide on liver fat content (LFC) in patients with non-alcoholic fatty disease (NAFLD).This was a phase IIa, randomized, active-comparator-controlled, parallel-group, open-label study. A magnetic resonance imaging-estimated proton density fraction assessment performed determine LFC at screening and Week 24. Participants an ≥10% were...
Abstract Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of and prevalence rising, especially in women. Although during reproductive age women are protected against FLD, for still unknown understudied reasons some develop rapidly progressive at menopause. The patatin-like phospholipase domain-containing 3 ( PNPLA3 ) p.I148M variant accounts largest fraction inherited FLD variability. In present study, we show that there a specific multiplicative interaction...
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients metabolic dysfunction-associated steatotic disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed role of serum ferritin predicting long-term outcomes or death. Design evaluated relationship between baseline and events a multicentre cohort 1342 patients. Four survival models considering confounders non-invasive scoring systems were applied repeated five-fold...
Sarcopenia and myosteatosis are common in patients with cirrhosis. This study aimed to determine the prevalence of these muscle changes, their interrelations prognostic impact over a 12-month period.
Porphyria cutanea tarda in human beings is believed to be due reduced hepatic uroporphyrinogen decarboxylase activity. However, extrinsic factors such as alcohol abuse and drug intake are required for clinical manifestation of the disease. In addition typical cutaneous lesions, patients with porphyria usually have chronic liver disease moderate iron overload. Of 74 Italian tarda, hepatitis C virus antibodies were detected 76% by enzyme-linked immunoassay 82% recombinant immunoblot assay....
OBJECTIVES Hyperferritinemia is frequently observed in nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome characterized by insulin resistance and considered high cardiovascular risk. Iron depletion phlebotomy has been reported to decrease NAFLD small, uncontrolled studies. Aims this study were define relationship between ferritin iron stores patients with NAFLD, effect on resistance, whether basal levels influence treatment outcome. METHODS Subjects...
It has been suggested that excess iron may facilitate the occurrence of cancer. Patients with hereditary hemochromatosis (HH) are at high risk developing liver cancer, and studies limited series reported a frequency nonhepatic cancers. To verify whether patients HH higher cancer other malignancies as compared non–iron-related chronic disease (CLD), we analyzed neoplasms in 230 CLD. The were matched by sex, age, duration follow-up (±5 years), severity disease. On enrollment, following...
The aim of this study was to define in patients with hyperferritinemia and normal transferrin saturation the relationships among hyperferritinemia, iron overload, HFE gene mutations, presence metabolic alterations, nonalcoholic steatohepatitis (NASH).Forty increased serum ferritin, resistant dietary restriction saturation, 90 ultrasonographic evidence hepatic steatosis, 60 obligate heterozygotes for hemochromatosis, all negative alcohol abuse, hepatitis virus infections, inflammation were...