A5042197526- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Pharmaceutical studies and practices
- Pancreatitis Pathology and Treatment
- Adolescent and Pediatric Healthcare
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Liver Disease and Transplantation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Digestive system and related health
- Hepatitis B Virus Studies
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Eosinophilic Disorders and Syndromes
- Hepatitis C virus research
Assaf Harofeh Medical Center
2016-2025
Tel Aviv University
2015-2024
Hebrew University of Jerusalem
2007
Adult and Pediatric Dermatology
2004
Sheba Medical Center
1992-2002
Schneider Children's Medical Center
2002
Wolfson Medical Center
1999-2002
Shaare Zedek Medical Center
2002
Bikur Cholim Hospital
2002
Soroka Medical Center
2002
Anti tumor necrosis factor alpha (TNFα) agents have become widely used in pediatric inflammatory bowel disease (IBD). So far, only few studies examined the long-term results of anti-TNFα treatment children with IBD.The outcome patients IBD was assessed retrospectively a multicenter cohort treated beyond induction treatment. Short- and response rates, predictors for loss response, data on growth laboratory parameters were assessed.120 [101 crohn's (CD), 19 ulcerative colitis (UC) or...
OBJECTIVES: Adalimumab is usually self-injected at home, making prospective serial-sampling studies challenging and scarce. This has led to a gap in knowledge about evolution of anti-adalimumab antibodies (AAAs) over time its correlation with clinical inflammatory outcomes. METHODS: A program for home visits by physicians induction, every 3 months event relapse, was established prospectively Crohn's disease (CD) patients. At each visit, patients' scores were determined sera obtained...
Abstract Background The Tasty&Healthy™ (T&H) diet offers a flexible alternative to exclusive enteral nutrition (EEN) for inducing remission in Crohn’s disease (CD). Unlike CDED, it excludes processed foods, gluten, red meat, and most dairy but does not rely on formula or mandatory ingredients. "MyTasty" trial aimed assess the effectiveness feasibility of T&H maintaining children adults with CD, gradual reintroduction gluten Methods Patients CD (4-37 years age) who entered deep...
Abstract Background Recent advances in inflammatory bowel disease (IBD) therapies have provided patients with a variety of medications different routes administration. We aimed to assess parental preferences regarding medication administration and identify factors influencing these Methods This cross-sectional study surveyed parents children IBD using comprehensive questionnaire that focused on treatment experiences, preferences, attitudes towards switching from intravenous (IV) subcutaneous...
Abstract Background Tasty&HealthyTM (T&H) is a whole food diet aimed at alleviating inflammation in Crohn’s disease (CD). It excludes processed food, gluten, red meat, and dairy (except for plain yogurt), but does not include mandatory ingredients or partial enteral nutrition with formula as the CD Exclusion Diet. In this RCT we evaluated T&H an intervention persistent subclinical compared continuing habitual diet. (NCT#04239248; TASTI-E). Methods Patients CD, aged 6-40 years,...
Abstract Background Long-term data on the use of vedolizumab in children with Crohn’s disease (CD) and ulcerative colitis (UC) are lacking drug is not yet approved pediatrics. The VEDOKIDS prospective multicenter cohort study aimed to assess effectiveness safety as maintenance therapy CD UC; this reports 3-year final visit outcomes (ClinicalTrials.gov, NCT02862132). Methods Children commenced at any duration degree activity were enrolled 17 pediatric centers Europe, USA Middle East followed...
Abstract Background Exclusive enteral nutrition (EEN) is effective for inducing remission in Crohn's disease (CD) but has adherence challenges. The CD-Exclusion Diet (CDED) an alternative requires partial (PEN) with formula and mandatory ingredients. Tasty&HealthyTM (T&H) diet excludes processed food, gluten, red meat, dairy (except plain yogurt) without ingredients or PEN. This randomized controlled trial assessed the tolerability effectiveness of T&H compared to EEN children...
Abstract Background Vedolizumab (VDZ) is effective to induce remission in children with Crohn disease (CD) and ulcerative colitis (UC), but effectiveness varies. Metabolites produced by interactions between intestinal microbiota host metabolic processes can be useful identify metabolome signatures that may preferentially favor response a specific therapeutic class. Therefore, metabolomic studies potentially inform precision medicine Inflammatory Bowel Diseases (IBD). Aims This study aimed...
Budesonide has been found effective in patients with mild and moderate Crohn disease to cause fewer side effects than prednisone. The use of oral budesonide not prospectively evaluated children disease. Therefore, the authors initiated a trial compare remission tolerance prednisone or moderately active disease.A prospective randomized open controlled 12-week was carried out comparing pH modified release budesonide, 9 mg, versus prednisone, 40 pediatric disease.Thirty-three (20 boys 13 girls;...
Abstract Background The PAILOT trial was a randomized controlled aimed to evaluate proactive vs reactive therapeutic drug monitoring in children with Crohn’s disease (CD) treated adalimumab. Our aim this post hoc analysis of the assess efficacy and safety adalimumab combination treatment comparison monotherapy at week 72 after induction. Methods Participants were 6–17 years old, biologic naïve, moderate severe CD, who responded induction 4. Patients receiving immunomodulators baseline...
The association between smoking and inflammatory bowel disease (IBD) is well established, but data in Jewish patients Israel were discrepant. aim of this study was to examine the habits IBD a large scale, multicenter study.Patients with established aged 18-70 yr interviewed relation other habits. Two controls (one clinic one neighborhood control matched by age, sex, community group, education) sought for each subject.A total 534 (273 ulcerative colitis [UC], 261 Crohn's [CD]), along 478 430...
ABSTRACT Background: Immunomodulatory drugs play a major role in maintaining remission and steroid sparing children with Crohn disease. Although thiopurine agents are commonly used, unresponsiveness or intolerance to these is common. The efficacy of methotrexate maintenance has been shown adult disease; however, pediatric data limited. Our goal was evaluate the safety induction clinical active disease who failed treatment. Patients Methods: In retrospective multicenter study, inducing...
Conflicting reports have noted a possible association linking eradication of Helicobacter pylori with aggravation gastroesophageal reflux (GER) disease. We prospectively evaluated the effect H on GER symptoms and epigastric pain among these 3 parameters in pediatric cohort.Patients who were referred for gastroscopy frequency, severity, nocturnal presence related to as well pain. Patients positive received triple antibiotic therapy. The patients followed at least 6 months after successful had...
Acute pancreatitis (AP) can be a rare extraintestinal manifestation of inflammatory bowel disease (IBD). There are only few reports AP presenting before the diagnosis IBD. We aimed to characterize demographic, clinical, and laboratory data patients with IBD in whom preceded onset compare presentation between children adults.Pediatric adult as first symptom were retrospectively identified (10 years, 7 university hospitals). Demographic clinical data, type, extension, extracted from charts....
The aim was to present the workup of patients with acute recurrent pancreatitis (ARP) for genetic analysis and electrophysiological testing.Patients ARP unknown etiology were referred testing evaluation cystic fibrosis transmembrane conductor regulator (CFTR) function by nasal potential difference (NPD) testing.A total 67 evaluated. mean age 23 ± 17 years (median 17.0 years, range 1.5-72 years); 90% Jewish 10% Arab. Ten (15%) carried PRSS1 gene mutation (K23R(7), R122H(2), D21A(1)). One...
We evaluated the efficacy of an oral formulation 5-amino-salicylic acid in lowering relapse rate after remission Crohn's disease. Included were 59 patients who had proven disease at least 1 year's duration, and been continuous for 6 months, while taking only 5-aminosalicylic or no therapy all. Remission was defined as a Harvey Bradshaw index score (Softley-Clamp modification) <4. Patients given coded mesalazine 250 mg placebo tablets (2×2 day). They seen 0, 1, 2 then every months until end...
Endoscopy and biopsy from a suspicious Vater's papilla may establish an early preoperative diagnosis of periampullary tumor. However, information regarding the diagnostic accuracy this procedure is limited variable. The aim present study was to evaluate retrospectively compared that other methods.Among 928 patients referred our institute for endoscopic retrograde cholangiopancreatography (ERCP), seen in 28. In each case comparison made between pre-ERCP clinical diagnosis, appearance,...