A5001593573- COVID-19 Clinical Research Studies
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Nerve Injury and Rehabilitation
- Sepsis Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Healthcare Systems and Public Health
- Dermatological and COVID-19 studies
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Elbow and Forearm Trauma Treatment
- Climate Change and Health Impacts
IRCCS Humanitas Research Hospital
2017-2024
University of Salerno
2020-2024
Humanitas University
2020-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Villa Pineta Hospital
2018-2023
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2021
Biogipuzkoa Health Research Institute
2020
Fondazione Humanitas per la Ricerca
1993-2019
IRCCS Eugenio Medea
2018
Ospedale dei Pellegrini
2006-2017
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Rationale: Screening for lung cancer with low-dose spiral computed tomography (LDCT) has been shown to reduce mortality by 20% compared screening chest X-ray (CXR) in the National Lung Trial, but uncertainty remains concerning efficacy of LDCT a community setting.Objectives: To explore effect on no screening. Secondary endpoints included incidence, stage, and resectability rates.Methods: Male smokers 20+ pack-years, aged 60 74 years, underwent baseline CXR sputum cytology examination...
We described features of hospitalized Covid-19 patients and identified predictors clinical deterioration. included consecutively admitted at Humanitas Research Hospital (Rozzano, Milan, Italy); retrospectively extracted demographic; clinical; laboratory imaging findings admission; used survival methods to identify factors associated with deterioration (defined as intensive care unit (ICU) transfer or death), developed a prognostic index. Overall; we analyzed 239 (29.3% females) mean age 63.9...
Several patients experience unexplained persistent symptoms after SARS-CoV-2 recovering. We aimed at evaluating if 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was able to demonstrate a inflammatory process. Recovered adult COVID-19 patients, who complained persisting for more than 30 days during the follow-up visits, were invited participate in study. Patients fulfilling inclusion criteria imaged by [18F]FDG positron emission tomography/computed tomography ([18F]FDG-PET/CT). Whole-body...
Risk stratification is crucial to optimise treatment strategies in patients with COVID-19. We aimed evaluate the impact on mortality of an early assessment cardiac biomarkers COVID-19.Humanitas Clinical and Research Hospital (Rozzano-Milan, Lombardy, Italy) a tertiary centre that has been converted management Patients confirmed COVID-19 were entered dedicated database for cohort observational analyses. Outcomes stratified according elevated levels (ie, above upper level normal)...
The COVID-19 pandemic has reached direct and indirect medical social consequences with a subset of patients who rapidly worsen die from severe-critical manifestations. As result, there is still an urgent need to identify prognostic biomarkers effective therapeutic approaches. Severe-critical manifestations are caused by dysregulated immune response. Immune checkpoint molecules such as Programmed death-1 (PD-1) its ligand programmed death-ligand 1 (PD-L1) play important role in regulating the...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Abstract Background Survivors of severe COVID-19 are at risk impaired health-related quality life (HRQoL) and persistent physical psychological disability after ICU hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, function prevalence post-traumatic stress symptoms invasively mechanically ventilated patients treated in our ICU. Methods Prospective, observational cohort study follow-up clinic. Patients completed 6-min walking test...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 189 000 people in Italy, with more than 25 deaths. Several predictive factors of mortality have been identified; however, none validated patients presenting mild disease.Patients a diagnosis interstitial pneumonia caused by SARS-CoV-2, symptoms, and requiring hospitalization non-intensive care unit known discharge status were prospectively collected retrospectively analysed. Demographical, clinical biochemical...
Anti-SARS-CoV-2 vaccines are safe and effective, also in individuals with allergic immune-mediated diseases (IMDs). There reports suggesting that may be able to trigger de-novo or exacerbate pre-existing IMDs predisposed individuals. Eosinophilic granulomatosis polyangiitis (EGPA) is a small-vessel vasculitis characterized by asthma, eosinophilia, eosinophil-rich granulomatous inflammation various tissues. We describe the case of 63-year-old man who experienced cardiac, pulmonary,...
Ursodeoxycholic acid (UDCA) was demonstrated to reduce susceptibility SARS-CoV-2 infection in vitro and improve course chronic liver diseases. However, real-life evidence is lacking. We analyzed the impact of UDCA on COVID-19 outcomes patients hospitalized a tertiary center. Between January 2020 2023, among 3847 consecutively for COVID19, 57 (=UDCA group) were taking UDCA. The control groups (n = 3790) did not differ concerning comorbidities including diabetes mellitus type 2 (15.8% vs....
Long-COVID syndrome is characterized by fatigue, orthostatic intolerance, tachycardia, pain, memory difficulties, and brain fog, which may be associated with autonomic nervous system abnormalities. We aimed to evaluate the short long-term course of COVID-19 symptoms quality life (QoL) after SARS-CoV-2 infection through a one-year follow-up combined validated questionnaires. Additionally, we identify patients worsening at 6 12 months dividing patient cohort into two sub-groups: Post-COVID...
COVID-19 diagnosis relies on molecular testing for SARS-CoV-2 via nasopharyngeal swab in the presence of suggestive clinical, radiological and laboratory findings. Since bronchoalveolar lavage liquid (BAL) collected during fibrobronchoscopy may increase test sensitivity compared to swabs, it was performed 2020 pandemic clinically or radiologically suspected cases. Our aim determine whether clinical features, chest computed tomography (CT) findings tests predict patients positive at BAL after...
The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of health care systems during highest viral diffusion rate. Patients reaching emergency department had to be either hospitalized (inpatients) or discharged (outpatients). Still, decision was taken based on individual assessment actual clinical condition, without specific biomarkers predict future improvement deterioration, and patients often returned hospital for aggravation their condition. Here, we have developed a new combined...
Abstract Long-COVID19 has been recently associated with long-sick leave and unemployment. The autonomic nervous system functioning may be also affected by SARS-CoV-2, leading to a chronic syndrome. This latter remains widely unrecognized in clinical practice. In the present study, we assessed occurrence of Autonomic Syndrome group active workers as well relationships between their dysfunction work ability. prospective observational study was conducted during 2nd wave pandemic Italy....
ObjectiveTo evaluate if the pandemic mitigation effects of lockdown in Italy have been influenced by level penetration COVID-19 Italian Regions at onset containment (March 9, 2020).MethodsWe collected data published day daily from first case until May 3, 2020, end lockdown, Italy's Protezione Civile Department. Linear regression analyses were performed to possible correlations between number confirmed cases/100.000 residents and new cases/100.000/day before with deaths/100.000 sixty days,...
Background: The incidence and prognosis of SARS-CoV-2-positive cancer patients on active oncologic treatment remain unknown. Retrospective data from China reported higher poorer outcomes with respect to the general population. We aimed describe real-word SARS-CoV-2 in impact therapies infection. Materials & Methods: In this study, we analysed all consecutive solid tumours undergoing intravenous (chemotherapy, immunotherapy, targeted therapy, alone or combination) between 21 February 30...