A5034036432- ECG Monitoring and Analysis
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Healthcare Technology and Patient Monitoring
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Analog and Mixed-Signal Circuit Design
- Blood Pressure and Hypertension Studies
- Phonocardiography and Auscultation Techniques
- Atrial Fibrillation Management and Outcomes
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Cardiovascular and exercise physiology
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Fault Detection and Control Systems
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Building Energy and Comfort Optimization
University of California, San Francisco
2018-2024
Flex (United States)
2006-2023
University of Rochester
1992-2022
University of Nevada, Reno
2022
Stanford Health Care
2022
National Center for Advancing Translational Sciences
2022
National Institutes of Health
2022
RELX Group (United States)
2021
Medidata (United States)
2018
University of Brescia
1994-2016
BACKGROUND The interval from the R wave to maximum amplitude of T (RTm) contains heart rate dependency ventricular repolarization. METHODS AND RESULTS A computer algorithm was developed quantify RTm and preceding RR intervals for each more than 50,000 beats on 24-hour ambulatory electrocardiographic (Holter) recordings evaluate dynamic relation between repolarization duration cycle length. (RTm/RR slope) determined by best-fit linear regression equation these two parameters. Eleven normal...
BackgroundConsumer devices with broad reach may be useful in screening for atrial fibrillation (AF) appropriate populations. However, currently no consumer are capable of continuous monitoring AF.ObjectiveThe purpose this study was to estimate the sensitivity and specificity a smartwatch algorithm detection AF from sinus rhythm free-living setting.MethodsWe studied commercially available photoplethysmography (W-PPG) electrocardiogram (W-ECG) capabilities. We validated novel W-PPG combined...
Congenital long-QT syndromes (cLQTS) or drug-induced (diLQTS) can cause torsade de pointes (TdP), a life-threatening ventricular arrhythmia. The current strategy for the identification of drugs at high risk TdP relies on measuring QT interval corrected heart rate (QTc) electrocardiogram (ECG). However, QTc has low positive predictive value.We used convolutional neural network (CNN) models to quantify ECG alterations induced by sotalol, an IKr blocker associated with TdP, aiming provide new...
To study the differences in QTc interval on ECG response to a single oral dose of rac-sotalol men and women.Continuous 12-lead ECGs were recorded 28 11 women separate baseline day following 160 mg day. extracted at prespecified time points upsampled 1000 Hz analyzed manually central laboratory superimposed median beat. Concentration-QTc analyses performed using linear mixed effects model.Rac-sotalol produced significant reduction heart rate women. An individual correction method (QTc I) most...
QT interval duration is longer in women than men. Sex steroid hormones have inconsistently been suggested to explain this difference. The implication of gonadotropins has never studied.We report here the combined influence sex and on healthy subjects patients with congenital adrenal hyperplasia (CAH) as a model T progesterone overexpression.Eighty-four CAH (58 women) 84 matched paired for age were prospectively included. Circulating concentrations 17-OH-progesterone, progesterone, T,...
Long-COVID syndrome is characterized by fatigue, orthostatic intolerance, tachycardia, pain, memory difficulties, and brain fog, which may be associated with autonomic nervous system abnormalities. We aimed to evaluate the short long-term course of COVID-19 symptoms quality life (QoL) after SARS-CoV-2 infection through a one-year follow-up combined validated questionnaires. Additionally, we identify patients worsening at 6 12 months dividing patient cohort into two sub-groups: Post-COVID...
Atrial fibrillation (AF), the most prevalent cardiac rhythm disorder, significantly increases hospitalization and health risks. Reverting from AF to sinus (SR) often requires intensive interventions. This study presents a deep-learning model capable of predicting transition SR on average 30.8 min before onset appears, with an accuracy 83% F1 score 85% test data. performance was obtained R-to-R interval signals, which can be accessible wearable technology. Our model, entitled Warning...
Mitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is orally bio-available small molecule under development the treatment mitochondrial(−related) diseases. The compound member new class drugs, acting as potent intracellular redox-modulating agent essential control oxidative redox pathologies. aim this randomized, placebo controlled, double-blinded phase 1 study was to test...
Objective: Indoor microclimate may affect students' wellbeing, cardiac autonomic control and cognitive performance with potential impact on learning capabilities. To assess the effects of classroom temperature variations profile Approach: Twenty students attending Humanitas University School, (14M, age 21 ± 3 years) underwent a single-lead ECG continuous recording by portable device during 2 h lecture when was set 'neutral' (20 °C–22 °C, Day 1) to 24 °C–26 °C (Day 2). ECGs were sent...
We test the hypothesis that degree of correlation between ventricular repolarization duration (VRD) and heart period (HP) carries information on cardiac autonomic regulation. The was assessed in frequency domain using squared coherence function during an experimental protocol known to gradually induce a shift sympathovagal balance toward sympathetic predominance (ie, graded head-up tilt). observed progressive decrease with tilt table inclination, thus confirming working hypothesis. VRD-HP...
Aim: Our aim was to investigate the prevalence and prognostic significance for fatal nonfatal cerebrovascular cardiovascular events of different ECG criteria left ventricular hypertrophy (LVH) in normal weight, overweight obese patients an adult Italian population. Methods: A total 18 330 adults (mean age 54 ± 11 years, 55% women, 53% hypertensive patients) were analyzed from Moli-sani cohort. Obesity defined using ATPIII criteria. ECG-LVH according 2013 ESC-ESH guidelines. Results: The sex...
Background: Measurement of short‐term fractal‐like correlation properties heart rate dynamics has been shown to be a useful prognostic indicator adverse events in cardiac patients. Complexity measurements variability (HRV) have already provided important information many conditions. However, data on the physiological background these newer nonlinear measures HRV are limited. Methods: Nine healthy subjects (aged from 22 35 years, 6 males, 3 females) had an electro‐cardiographic (ECG)...