A5067158748- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Diabetes Treatment and Management
- Frailty in Older Adults
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Dementia and Cognitive Impairment Research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
- Heart Rate Variability and Autonomic Control
- Neurological Disorders and Treatments
- Heart Failure Treatment and Management
- Neurological Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Acute Myocardial Infarction Research
Casa di cura Pierangeli
2023-2025
Albert Einstein College of Medicine
2020-2025
University of Molise
2023-2025
Feinstein Institute for Medical Research
2022-2025
Ministero della Salute
2023-2024
Institute of Food Science
2021-2024
The Bronx Defenders
2024
Hospital Montecelo
2024
Federico II University Hospital
2024
New York Proton Center
2023-2024
Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, both these conditions are associated endothelial dysfunction oxidative stress. We investigated the functional role of SGLT2 (sodium glucose cotransporter 2) inhibitor empagliflozin frail diabetic hypertensive adults.
To assess whether the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improves cognitive impairment in frail older adults with diabetes and heart failure preserved ejection fraction (HFpEF).We designed a prospective study to physical function consecutive HFpEF, comparing effects of empagliflozin, metformin, insulin.A total 162 HFpEF successfully completed study. Montreal Cognitive Assessment scores at baseline after 1 month were 19.80 ± 3.77 vs. 22.25 3.27 (P < 0.001) group,...
Emerging evidence suggests that elevated circulating levels of HDL-C (high-density lipoprotein cholesterol) could be linked to an increased mortality risk. However, the best our knowledge, relationship between and specific cardiovascular events has never been investigated in patients with hypertension.To fill this knowledge gap, we analyzed hypertensive within Campania Salute Network Southern Italy.We studied 11 987 hypertension, who were followed for 25 534 person-years. Our population was...
Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.
Endothelial dysfunction represents a key mechanism underlying heart failure with preserved ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers to monitor endothelial in these patients are lacking. In this study, we evaluated the expression of panel circulating microRNAs (miRs) involved regulation function frail older adults HFpEF DM that were treated for 3 months empagliflozin, metformin, or insulin. We identified unique pattern miRs significantly...
Abstract Background Diabetes and hypertension are common in older adults represent established risk factors for frailty. Frailty is a multidimensional condition due to reserve loss susceptibility stressors with high of death, hospitalizations, functional cognitive impairment. Comorbidities such as diabetes play key role increasing the mortality, hospitalization, disability. Moreover, frail patients known have an increased physical Nevertheless, no study assessed correlation between...
Frailty is a multidimensional condition typical of elders. Frail older adults have high risk functional decline, hospitalization, and mortality. Hypertension one the most common comorbidities in Hyperglycemia (HG) frequently observed frail adults, represents an independent predictor worst outcomes, with or without diabetes mellitus (DM). We aimed at investigating impact HG on physical impairment frailty.We studied consecutive frailty hypertension ASL (local health unit Italian Ministry...
OBJECTIVE Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding in patients angina. However, the main factors underlying risk of being rehospitalized for chest pain INOCA remain mostly unknown. RESEARCH DESIGN AND METHODS We evaluated referred to “Casa di Cura Montevergine” Mercogliano (Avellino), Italy, from January 2016 2021 percutaneous intervention (PCI). In these subjects, we assessed impact stress hyperglycemia ratio (SHR), defined as mmol/L blood glucose and %...
We hypothesized that exosomal microRNAs (miRNAs) could be implied in the pathogenesis of thromboembolic complications COVID-19. isolated circulating exosomes from COVID-19 patients and then we divided our population two arms based on D-dimer level hospital admission. observed miR-145 miR-885 significantly correlate with D-Dimer levels. Moreover, demonstrate human endothelial cells express main cofactors needed for SARS-CoV-2 internalization, including ACE2, TMPRSS2, CD-147. Interestingly,...
Abstract Aims Pre-diabetes is a condition that confers an increased cardiovascular risk. Frailty very common in hypertensive patients, and insulin resistance has been linked to frailty older adults with diabetes. On these grounds, our aim was evaluate the association between cognitive impairment pre-diabetic frail adults. Methods results We studied consecutive elders presenting at Avellino local health authority of Italian Ministry Health (ASL AV) from March 2021 2022. All them fulfilled...
Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact molecular processes underlying this disorder are not fully known. This study includes comprehensive and coordinated set in vivo vitro experiments using human specimens from patients with postischemic heart failure (HF) healthy control subjects, murine model HF, cellular systems. These approaches identified for first time specific pattern maladaptive chromatin remodeling, namely double methylation histone 3...