A5046754209- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Extracellular vesicles in disease
- Cardiac electrophysiology and arrhythmias
- Nutrition and Health in Aging
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Cardiomyopathy and Myosin Studies
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disorders and Treatments
- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
Albert Einstein College of Medicine
2021-2025
Feinstein Institute for Medical Research
2021-2025
New York City Police Department
2024
Federico II University Hospital
2022-2024
The Bronx Defenders
2023-2024
Hospital Montecelo
2024
New York Proton Center
2023-2024
Montefiore Health System
2023
Cardiovascular Institute Hospital
2022
Louisiana Tech University
2018-2021
Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive....
Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.
Endothelial dysfunction represents a key mechanism underlying heart failure with preserved ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers to monitor endothelial in these patients are lacking. In this study, we evaluated the expression of panel circulating microRNAs (miRs) involved regulation function frail older adults HFpEF DM that were treated for 3 months empagliflozin, metformin, or insulin. We identified unique pattern miRs significantly...
We hypothesized that exosomal microRNAs (miRNAs) could be implied in the pathogenesis of thromboembolic complications COVID-19. isolated circulating exosomes from COVID-19 patients and then we divided our population two arms based on D-dimer level hospital admission. observed miR-145 miR-885 significantly correlate with D-Dimer levels. Moreover, demonstrate human endothelial cells express main cofactors needed for SARS-CoV-2 internalization, including ACE2, TMPRSS2, CD-147. Interestingly,...
Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact molecular processes underlying this disorder are not fully known. This study includes comprehensive and coordinated set in vivo vitro experiments using human specimens from patients with postischemic heart failure (HF) healthy control subjects, murine model HF, cellular systems. These approaches identified for first time specific pattern maladaptive chromatin remodeling, namely double methylation histone 3...
Emerging evidence indicates that the relationship between coronavirus disease 2019 (COVID-19) and diabetes is 2-fold: 1) it known presence of other metabolic alterations poses a considerably high risk to develop severe COVID-19; 2) patients who survived acute respiratory syndrome 2 (SARS-CoV-2) infection have an increased developing new-onset diabetes. However, mechanisms underlying this association are mostly unknown, there no reliable biomarkers predict development In present study, we...
Alzheimer's disease (AD) is a neurodegenerative disorder marked by amyloid-β accumulation, tau dysfunction, and neuroinflammation, involving endothelial cells leukocytes. The breakdown of the blood-brain barrier allows immune cell infiltration, intensifying inflammation. A decreased ratio Connexin-37 (Cx37, also known as GJA4: Gap Junction Protein Alpha 4) Prolyl Hydroxylase Domain-Containing 3 (PHD3, EGLN3: Egl-9 Family Hypoxia Inducible Factor 3), Cx37/PHD3, consistently observed in...