A5088545874- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Failure Treatment and Management
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Cardiovascular Syncope and Autonomic Disorders
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Extracellular vesicles in disease
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
University of Campania "Luigi Vanvitelli"
2016-2025
ASL Roma
2020-2024
University of Salerno
2024
Saint Camillus International University of Health and Medical Sciences
2020-2021
University of Naples Federico II
2007-2020
Policlinico S.Orsola-Malpighi
2020
University of Bologna
2020
Ospedale dei Pellegrini
2020
Agostino Gemelli University Polyclinic
2020
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2020
OBJECTIVE An important prognostic factor in any form of infection seems to be glucose control patients with type 2 diabetes. There is no information about the effects tight glycemic on coronavirus disease 2019 (COVID-19) outcomes hyperglycemia. Therefore, we examined optimal hyperglycemia affected by COVID-19. RESEARCH DESIGN AND METHODS Fifty-nine COVID-19 hospitalized moderate were evaluated. On basis admission glycemia >7.77 mmol/L, divided into hyperglycemic and normoglycemic...
Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent critical for excitation-contraction coupling; however, functional role RyR2 in cell insulin secretion diabetes mellitus remains controversial. Here, we took advantage rare mutations that were identified patients with genetic form exercise-induced sudden death (catecholaminergic polymorphic...
The role of sirtuin 6 (SIRT6) in atherosclerotic progression diabetic patients is unknown. We evaluated SIRT6 expression and the effect incretin-based therapies carotid plaques asymptomatic nondiabetic patients. Plaques were obtained from 52 type 2 30 undergoing endarterectomy. Twenty-two treated with drugs that work on incretin system, GLP-1 receptor agonists, dipeptidyl peptidase-4 inhibitors for 26 ± 8 months before Compared plaques, had more inflammation oxidative stress, along a lesser...
Abstract Background The inflammatory response occurring in acute myocardial infarction (AMI) has been proposed as a potential pharmacological target. Sodium-glucose co-transporter 2 inhibitors (SGLT2-I) currently receive intense clinical interest patients with and without diabetes mellitus (DM) for their pleiotropic beneficial effects. We tested the hypothesis that SGLT2-I have anti-inflammatory effects along glucose-lowering properties. Therefore, we investigated link between stress...
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the of a poor outcome. DKD is associated very high cardiovascular risk, which requires simultaneous treatment these by implementing an intensified multifactorial approach. However, efficacy intervention on major fatal/non-fatal events (MACEs) has been poorly investigated.
To investigate in-hospital and long-term prognosis in T2DM patients presenting with acute myocardial infarction (AMI) treated SGLT2-I versus other oral anti-diabetic agents (non-SGLT2-I users).
Abstract Background Sodium–glucose transporter 2 inhibitors (SGLT2-I) could modulate atherosclerotic plaque progression, via down-regulation of inflammatory burden, and lead to reduction major adverse cardiovascular events (MACEs) in type diabetes mellitus (T2DM) patients with ischemic heart disease (IHD). T2DM multivessel non-obstructive coronary stenosis (Mv-NOCS) have over-inflammation over-lipids’ accumulation. This reduce fibrous cap thickness (FCT), favoring rupture MACEs. Despite...
No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not sodium/glucose cotransporter inhibitors (SGLT2i).We recruited 377 T2DM AMI undergoing percutaneous coronary intervention (PCI). Among them, 177 were SGLT2 before PCI. The primary outcome was major adverse cardiovascular (MACE) defined as cardiac death, re-infarction, heart failure related to ISR. In without ISR, minimal...
Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class of lipid-lowering drugs suggested to hold plethora beneficial effects independent their LDL cholesterol-lowering properties.However, the mechanism underlying such observations is debated.Methods: Human aortic endothelial cells (TeloHAEC) were pre-treated with 100 µg/mL PCSK9i evolocumab and then exposed 20 ng/mL IL-6, major driver cardiovascular diseases (CVD), in both naïve state after...
Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive....
Abstract Background Few studies explored the effect of combination glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on incidence cardiovascular events in patients with type 2 diabetes (T2D) acute myocardial infarction (AMI). Methods We recruited T2D AMI undergoing percutaneous coronary intervention, treated either SGLT-2i or GLP-1RA for at least 3 months before hospitalization. Subjects HbA1c < 7% admission were considered good...
OBJECTIVE To evaluate the effect of metformin therapy on coronary endothelial function and major adverse cardiac events (MACE) in patients with prediabetes stable angina nonobstructive stenosis (NOCS). RESEARCH DESIGN AND METHODS Metformin may be needed to reduce heart disease risk prediabetes. A total 258 propensity score–matched (PSM) undergoing angiography were enrolled study. Data from 86 PSM subjects normoglycemia (NG), (pre-DM), treated (pre-DM metformin) analyzed. During angiography,...
The symptoms most commonly reported by patients affected coronavirus disease 2019 (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 (e.g. high blood pressure, thrombosis, pulmonary embolism) seem to suggest that the virus is targeting endothelium, one largest organs human body. Herein, we report both clinical preclinical evidence supporting hypothesis endothelium a key target organ COVID-19.
The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme (ACE2) and transmembrane protease serine (TMPRSS2). Here, we focused on study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, identified miR-98-5p as suitable candidate. Since others have shown endothelial play pivotal role in pathogenesis disease 2019 (COVID-19), mechanistically validated regulator TMPRSS2...
Abstract A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease mortality during Covid-19 However, the rates severe are significantly higher in compared non-diabetes (34.6% vs. 14.2%; p < 0.001). Similarly, have need for Intensive Care Unit (ICU, 37.0% 26.7%; = 0.028). Thus, about pneumonia Covid-19, we might speculate that complicated alveolar-capillary...
Abstract Rationale About 50% of hospitalized coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM) developed myocardial damage. The mechanisms direct SARS-CoV-2 cardiomyocyte infection include viral invasion via ACE2-Spike glycoprotein-binding. In DM patients, the impact glycation ACE2 on by can be high importance. Objective To evaluate presence in cardiomyocytes from heart autopsy cases compared to Non-DM; investigate role SARS-COV-2 entry cardiomyocytes. Methods and...
In patients with Normal Glucose Tolerance (NGT) some causes of ischemic heart disease (IHD) were not completely investigated. The role both metabolic milieu and adipokines in IHD progression was fully Our aim to assess the link between plasma levels, insulin resistance (IR) NGT undergoing Percutaneous Coronary Intervention (PCI). AIRE is a single-center prospective longitudinal observational study investigating outcome subjects who underwent coronary revascularization by PCI third level...