A5013371542- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Enzyme function and inhibition
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Diversity and Career in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Kidney Disease and Diabetes
- Medical Education and Admissions
- Innovations in Medical Education
- Pharmacology and Obesity Treatment
- Chronic Disease Management Strategies
- Renin-Angiotensin System Studies
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Amino Acid Enzymes and Metabolism
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
Aston University
2014-2025
University of Campania "Luigi Vanvitelli"
2011-2022
University of Birmingham
2013-2018
Heart of England NHS Foundation Trust
2018
Queen Elizabeth Hospital
2014
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the of a poor outcome. DKD is associated very high cardiovascular risk, which requires simultaneous treatment these by implementing an intensified multifactorial approach. However, efficacy intervention on major fatal/non-fatal events (MACEs) has been poorly investigated.
Background Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels activity. Whilst questionnaire-based studies have examined barriers to exercise in T1DM, formal qualitative analysis these been undertaken. Our aims were explore attitudes, and facilitators patients Methodology A purposeful sample long standing T1DM invited participate this study. Twenty-six adults interviewed using...
Nephropathy in Diabetes type 2 (NID-2) study is an open-label cluster randomized clinical trial that demonstrated multifactorial intensive treatment reduces Major Adverse Cardiac Events (MACEs) and overall mortality versus standard of care diabetic subjects with albuminuria no history cardiovascular disease. Aim the present post-hoc analysis NID- to evaluate whether number risk factors on target associates patient outcomes.Intervention phase lasted four years subsequent follow up for...
Background Diabetes mellitus ( DM ) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases CAs have been shown to play a major role in diabetic microangiopathy but their the cardiomyopathy is still unknown. Methods and Results We obtained left ventricular samples from patients with type 2 (DM‐T2) nondiabetic NDM postinfarct heart failure who were undergoing surgical coronary revascularization. Myocardial levels of CA ‐I CA‐ II 6‐ 11‐fold higher,...
ABSTRACT Background Clinical teaching fellows (CTFs) enhance medical students' education, yet their role in early undergraduate years is less understood. This study explores the key attributes of CTFs, as perceived by students, CTFs and staff, that contribute to quality learning experiences school. Methods mixed‐methods was conducted at a UK school, involving surveys focus groups with 102 early‐year MBChB (Bachelor Medicine, Bachelor Surgery) five 15 staff. Participants identified CTF...
Abstract Background Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise not been examined 1 Significant function is present at the time diagnosis diabetes and therefore studies preservation are ideally conducted immediately after diagnosis. Many variables required to design power such study currently unknown. The aim EXTOD obtain information formal newly diagnosed Methods Barriers will initially be assessed qualitative patients. Then, sixty...
The prevalence of T2DM in youth is increasing dramatically worldwide, but the bulk increase expected to take place Africa, South East Asia and America. Although genetic factors may seem be obvious reason for such geographical differences, a careful analysis existing literature suggests that many need considered: ethnic differences genes associated with obesity or insulin action/secretion have not been clearly identified; role intrauterine retardation postnatal growth has well-studied India...
Background: Early onset of type 2 diabetes (T2DM) is associated with prolonged exposure to hyperglycaemia and increased propensity chronic complications. The aim this study was characterize compare the phenotypic characteristics risk factors in a multi-ethnic cohort young adults (T2DMY).Methods: One hundred (White European [WE], South Asian [SA] African-Caribbean [AC]) diagnosed T2DM before age 40 years were recruited. Demographics, family history, related complications, co-morbidities,...
Although numerous studies and metanalysis have shown the beneficial effect of statin therapy in CVD secondary prevention, there is still controversy such use statins for primary prevention patients with DM. The purpose this study was to evaluate occurrence total major adverse cardio-vascular events (MACE) a cohort type 2 diabetes complicated by nephropathy treated statins, order verify real life on prevention. We conducted an observational prospective multicenter 564 diabetic free...
Objective: Non-invasive testing often does not identify coronary artery disease (CAD) in diabetic subjects. This study was designed order to examine the prevalence of CAD a cohort asymptomatic type 2 patients at high cardiovascular risk and negative nuclear imaging, using multi-slice computed tomography (MSCT) angiography. Methods: In total, 770 were screened from January 2008 through July 2010. Of these, 132 Caucasians with nephropathy for angina eligible cross-sectional study. Patients...